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DLL3 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    DLL3 Recombinant Monoclonal Antibody
  • 货号：
    CSB-RA882142MA2HU
  • 规格：
    ￥1320
  • 图片：
    • The Binding Activity of Human DLL3 with Anti-DLL3 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DLL3 (CSB-MP882142HU2d7) at 2 μg/mL can bind Anti-DLL3 recombinant antibody. The EC50 is 3.990-4.723 ng/mL.
    • The Binding Activity of Human DLL3 with Anti-DLL3 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DLL3 (CSB-MP882142HU3) at 1 μg/mL can bind Anti-DLL3 recombinant antibody. The EC50 is 6.080-7.240 ng/mL.
    • The Binding Activity of Human DLL3 with Anti-DLL3 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DLL3 (CSB-MP882142HU3d7) at 2 μg/mL can bind Anti-DLL3 recombinant antibody. The EC50 is 1.107-1.282 ng/mL.
    • The Binding Activity of Human DLL3 with Anti-DLL3 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DLL3 (CSB-MP882142HU2) at 1 μg/mL can bind Anti-DLL3 recombinant antibody. The EC50 is 6.211-7.209 ng/mL.
    • SHP-77 cells were stained with Human IgG1&Igκ Isotype Control (CSB-RA011156MA1HU)(green line) and anti-DLL3 antibody (CSB-RA882142MA2HU) (2µg/1*106cells) (red line), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
    • The purity of DLL3 was greater than 95% as determined by SEC-HPLC
  • 其他：

产品详情

  • Uniprot No.：
    Q9NYJ7
  • 基因名：
    DLL3
  • 别名：
    Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3), DLL3
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DLL3 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    hIgG1
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    7B11
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, FC
  • 推荐稀释比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Flow cytometry (FC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶点详情

  • 功能：
    Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
  • 基因功能参考文献：
    1. these results reveal that DLL3 is expressed in tumor specimens from most patients with small cell lung cancer PMID: 29290251
    2. Results indicated that DLL3 expression was silenced in hepatocellular carcinoma (HCC) cells by DNA methylation and was more readily affected by histone acetylation than histone methylation (H3K9me2 or H3K27me3). PMID: 29512761
    3. our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis PMID: 28705113
    4. The Dll3 was rarely detectable in the para-carcinoma tissues, but positive in 82.1% of non-small cell cancer tissues. PMID: 28007595
    5. Both global haplotype and individual haplotype analyses showed that the haplotypes of SNP1/SNP2/SNP3/SNP4/SNP5 did not correlate with the disease (P >0.05). Together, these data suggest that genetic variants of the DLL3 gene are not associated with CS in the Chinese Han population. PMID: 27472720
    6. DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells. PMID: 23337976
    7. We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice. PMID: 11923214
    8. mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis PMID: 12746394
    9. no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis. PMID: 15717203
    10. The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PMID: 18676613

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  • 相关疾病：
    Spondylocostal dysostosis 1, autosomal recessive (SCDO1)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 数据库链接：

    HGNC: 2909

    OMIM: 277300

    KEGG: hsa:10683

    STRING: 9606.ENSP00000205143

    UniGene: Hs.127792

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