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  4. LDHC Recombinant Monoclonal Antibody

LDHC Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    LDHC重组抗体
  • 货号：
    CSB-RA886298A0HU
  • 规格：
    ￥1320
  • 图片：
    • Overlay Peak curve showing Hela cells stained with CSB-RA886298A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

产品详情

  • 产品描述：
    CSB-RA886298A0HU LDHC重组单克隆抗体是针对乳酸脱氢酶C亚基（LDHC）开发的高特异性科研试剂。该抗体通过重组蛋白免疫策略制备，经ELISA和流式细胞术（FC）严格验证，在FC应用中推荐使用1:50-1:200稀释比例。LDHC作为糖酵解关键酶，特异性地表达于生殖细胞及多种肿瘤组织，其异常表达与精子活力调控及肿瘤代谢重编程密切相关。本产品能特异性识别天然构象的LDHC蛋白，在FC检测中展现出优异的信号分辨率和低背景特性，适用于活细胞表面标记及胞内蛋白定位分析。该抗体具有高批次稳定性，可为生殖生物学研究（如精子功能评估）、肿瘤微环境代谢研究（包括肿瘤细胞能量代谢通路解析）以及生殖系统相关疾病机制探索提供可靠工具。其优化的FC性能特别适合用于流式细胞术检测中低丰度靶标的精准识别，为科研人员开展细胞水平的功能研究提供有效支持。
  • Uniprot No.：
    P07864
  • 基因名：
    LDHC
  • 别名：
    L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X), LDHC, LDH3 LDHX
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human LDHC
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    9F2
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, FC
  • 推荐稀释比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Flow cytometry (FC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶点详情

  • 功能：
    Possible role in sperm motility.
  • 基因功能参考文献：
    1. Lactate dehydrogenase C may act as a novel biomarker for renal cell carcinoma progression and a potential therapeutic target for the treatment of renal cell carcinoma. PMID: 28351304
    2. three uniquely identified proteins (CDK6 , galectin-3-binding protein and LDH C) were found, which show tight connection with prostate cancer and presence of all of them was previously linked to certain aspects of prostate cancer PMID: 26503549
    3. Down-regulated LDH-C4 expression is significantly correlated with lowered enzyme activity in human spermatozoa. PMID: 25795631
    4. This is the first report to show a positive correlation between LDH-3 and hemolytic parameters in sickle cell anemia. PMID: 26069337
    5. LDH3 was increased in essential thrombocythemia. This isoenzymatic pattern could be expression of a metabolic adaptation. PMID: 17178662
    6. LDH3 is a supporting diagnostic marker in cases of chronic tuberculosis. PMID: 17935709
    7. hLdhc expression in cancer cells was regulated by transcription factor Sp1 and CREB and promoter CGI methylation PMID: 18930904

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    LDH/MDH superfamily, LDH family
  • 数据库链接：

    HGNC: 6544

    OMIM: 150150

    KEGG: hsa:3948

    STRING: 9606.ENSP00000280704

    UniGene: Hs.654377

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