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LTBR Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    LTBR Recombinant Monoclonal Antibody
  • 货号：
    CSB-RA013227MA1HU
  • 规格：
    ￥1320
  • 图片：
    • The Binding Activity of Human LTBR with Anti-LTBR Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LTBR(CSB-MP013227HU1) at 2 μg/mL can bind Anti-LTBR recombinant antibody. The EC50 is 0.6450-0.8200 ng/mL.
    • The Binding Activity of Human LTBR with Anti-LTBR Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LTBR (CSB-YP013227HU1) at 2 μg/mL can bind Anti-LTBR recombinant antibody. The EC50 is 0.5282-0.6120 ng/mL.
  • 其他：

产品详情

  • 产品描述：
    LTBR Recombinant Monoclonal Antibody（CSB-RA013227MA1HU）是针对淋巴毒素β受体（LTBR）研发的高特异性抗体，靶向于肿瘤坏死因子受体超家族成员LTBR。该受体在淋巴器官发育、免疫稳态调控及炎症反应中发挥重要作用，参与B细胞分化、生发中心形成等关键生物学过程。本产品经ELISA验证显示优异的检测性能，推荐使用稀释比例为1:5000至1:50000，可精准识别天然构象下的LTBR抗原表位，适用于体外实验中的靶蛋白定量分析与功能研究。其高批次间稳定性和低交叉反应性特点，为免疫学、肿瘤微环境及自身免疫性疾病机制研究提供可靠工具，可应用于受体-配体互作研究、免疫细胞信号通路解析或炎症相关分子网络构建等科研场景，助力于探索LTBR在免疫调节及病理状态中的分子调控机制。
  • Uniprot No.：
    P36941
  • 基因名：
    LTBR
  • 别名：
    CD18 antibody; D12S370 antibody; LT beta R antibody; LTBETAR antibody; Ltbr antibody; Lymphotoxin B receptor antibody; Lymphotoxin beta receptor (TNFR superfamily; member 3) antibody; Lymphotoxin beta receptor antibody; Lymphotoxin-beta receptor antibody; TNF R III antibody; TNF-RIII antibody; TNFCR antibody; TNFR RP antibody; TNFR superfamily member 3 antibody; TNFR-III antibody; TNFR2 RP antibody; TNFR2RP antibody; TNFR3 antibody; TNFRII antibody; TNFRRP antibody; TNFRSF 3 antibody; TNFRSF3 antibody; TNR3_HUMAN antibody; Tumor necrosis factor C receptor antibody; Tumor necrosis factor receptor 2 related protein antibody; Tumor necrosis factor receptor 2-related protein antibody; Tumor necrosis factor receptor superfamily member 3 antibody; Tumor necrosis factor receptor superfamily member 3 precursor antibody; Tumor necrosis factor receptor type III antibody
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human LTBR protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    hIgG1
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    7G6
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:5000-1:50000
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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LTBR antibodies

LTBR Proteins

靶点详情

  • 功能：
    Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
  • 基因功能参考文献：
    1. the lymphotoxin beta receptor (LTbetaR) to elicit the fast release of NF-kappaB inducing kinase (NIK) from the receptor complex leading to non-canonical NF-kappaB signaling. PMID: 29329668
    2. these results suggest that the LTBR rs12354 polymorphism might be associated with the spontaneous resolution of hepatitis B virus infection PMID: 28575727
    3. LTBR and BCLAF1 showed higher DNA methylation percentages in the marsupialized OKCs, but this difference did not affect gene expression (P > .05). PMID: 28864293
    4. membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B EAE development PMID: 27820602
    5. LIGHT and LTBR interaction increases the survival and proliferation of human bone marrow-derived mesenchymal stem cells, and therefore, LIGHT might play an important role in stem cell therapy. PMID: 27835685
    6. We found that LTbetaR polymorphisms caused severe BPH. Thus, LTbetaR may contribute to the risk of BPH development. PMID: 26782510
    7. activation enhances the LPS-induced expression of IL-8 through NF-kappaB and IRF-1 PMID: 25887375
    8. LIGHT, via LTbetaR signaling, may contribute to exacerbation of airway neutrophilic inflammation through cytokine and chemokine production by bronchial epithelial cells. PMID: 25501580
    9. Relative expression of HVEM and LTbetaR modulates canonical NF-kappaB and pro-apoptotic signals stimulated by LIGHT. PMID: 24980868
    10. lymphotoxin-B-specific receptor. PMID: 24563505
    11. Dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction. PMID: 24248355
    12. Results suggest that blockade of lymphotoxin-beta receptor (LTBR) pathways may have therapeutic potential for treatment of Sjogren's syndrome. PMID: 22044682
    13. LTBR gene polymorphisms may be associated with risk of IgA nephropathy in Korean children PMID: 22417320
    14. show that a cognate interaction between LTalphabeta on CD4(+) helper T cells and LTbeta receptor on DCs results in unique signals that are necessary for optimal CD8(+) T-cell expansion via a type I IFN-dependent mechanism PMID: 21245292
    15. These results indicated that AdipoR1 interacted with LTBR and mediated the inhibition of LTBR-activated NF-kappaB pathway. PMID: 21195057
    16. LTbetaR levels are independently associated with atherosclerosis in multiple vascular beds PMID: 20599198
    17. Increased potential for LTbeta receptor signaling, coupled with increased bioavailability due to lower decoy receptor-3 (DcR3) avidity, provides a mechanism for polymorphic variants in LIGHT to contribute to the pathogenesis of inflammatory diseases. PMID: 20592286
    18. the LTbetaR modifies the ubiquitin:NIK E3 ligase, and also acts as an allosteric regulator of the ubiquitin:TRAF E3 ligase PMID: 20348096
    19. Modulation of cellular TRAF3 levels may thus contribute to regulation of NFkappaB-dependent gene expression by LTBR by affecting the balance of LTBR-dependent activation of canonical and non-canonical NFkappaB pathways. PMID: 20185819
    20. Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.(AP-1) PMID: 12169272
    21. The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536. PMID: 12419817
    22. Data show that mRNA encoding LIGHT and its receptors [HVEM, LTbetaR, and TR6 (DcR3)] are present in placentas and cytotrophoblast cells at term. PMID: 12466117
    23. GA-binding protein (GABP) and Sp1 and retinoid receptors are required to mediate retinoic acid responsiveness of CD18 transcriptional activation in myeloid cells. PMID: 12485937
    24. ASK1 is one of the factors involved in the caspase-independent pathway of LTbetaR-induced cell death. PMID: 12566458
    25. TRAF2, TRAF3, cIAP1, Smac, and lymphotoxin beta receptor associate and are involved in apoptosis PMID: 12571250
    26. LTbetaR, CD40 and TANK interact with TRAF3 at sites that promote molecular interactions driving specific signaling PMID: 14517219
    27. both LTbetaR and HVEM can discriminatively mediate the expression of different genes in cultured human umbilical vein endothelial cells, including LIGHT, a proinflammatory cytokine PMID: 15917993
    28. Signaling through the lymphotoxin beta receptor (LTbetaR) expressed on mature hepatocytes induces massive hepatomegaly; LTbetaR and its ligands define a new pathway in supporting liver regeneration PMID: 16002734
    29. Blockade of TNFSF14 signaling caused a substantial reduction in the expression of lymphotoxin beta receptor (LTbetaR)-controlled migration factors within the islets and disrupts organization of tertiary structures, leading to prevention of diabetes. PMID: 16934497
    30. membrane-bound receptor that mediates apoptosis (LTbetaR) was present in syncytiotrophoblast and cytotrophoblast cells in all samples but were detected in placental stromal cells only at week 8 and thereafter PMID: 17010447
    31. Evidence in this review indicates that double positive-thymocytes regulate the differentiation of early thymocyte progenitors and gamma delta T cells through a mechanism dependent on LT beta receptor. PMID: 17336158
    32. These results define a model for the study of inflammatory lymphangiogenesis in the thyroid and implicate lymphotoxin beta receptor signaling in this process. PMID: 17360402
    33. This review discusses recent studies indicating that LT beta R signaling is required for liver regeneration, hepatitis, and hepatic lipid metabolism. PMID: 17896993
    34. Lymphotoxin beta receptor ligation directly activates gene expression in human vascular endothelial cells via both noncanonical and classical NF-kappa B pathways. PMID: 18292573
    35. LTbeta-R constitutively induces NF-kappaB activation, and this event may be associated with autonomous growth of melanoma cells. PMID: 18347013
    36. lymphotoxin beta receptor (LTbetaR) was detected in Rheumatoid arthritis fibroblast-like synoviocytes PMID: 18412315

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 数据库链接：

    HGNC: 6718

    OMIM: 600979

    KEGG: hsa:4055

    STRING: 9606.ENSP00000228918

    UniGene: Hs.1116

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