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  4. MRAS Recombinant Monoclonal Antibody

MRAS Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    MRAS重组抗体
  • 货号：
    CSB-RA158563A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, PC3 whole cell lysate, Hela whole cell lysate, A549 whole cell lysate, HEK293 whole cell lysate
      All lanes: MRAS antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 24, 16 kDa
      Observed band size: 24 kDa
  • 其他：

产品详情

  • 产品描述：
    MRAS Recombinant Monoclonal Antibody（CSB-RA158563A0HU）是针对MRAS蛋白开发的高特异性抗体，靶向RAS家族中参与细胞信号转导调控的关键成员MRAS。该蛋白通过介导RAS/MAPK信号通路调控细胞增殖、分化与存活，其异常表达与多种肿瘤发生及转移密切相关。本抗体采用重组表达技术制备，经严格验证可在Western Blot（WB）实验中稳定识别天然及重组MRAS蛋白，推荐使用稀释比为1:500-1:2000，实验结果显示特异性结合且背景干扰低，同时适用于ELISA平台对目标蛋白的定量检测。该产品为科研领域提供可靠工具，可应用于肿瘤发生机制研究、MAPK信号通路调控分析、体外细胞模型功能验证等场景，尤其适用于探索MRAS在癌症生物学中的功能及其与其他RAS家族蛋白的相互作用研究，为靶向治疗开发提供基础实验支持。
  • Uniprot No.：
    O14807
  • 基因名：
    MRAS
  • 别名：
    Ras-related protein M-Ras (Ras-related protein R-Ras3), MRAS, RRAS3
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human MRAS
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    18E11
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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MRAS antibodies

MRAS Proteins

靶点详情

  • 功能：
    Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
  • 基因功能参考文献：
    1. acute coronary syndrome in Czechs (30.4% vs 29.4% carriers of the minor T allele of MRAS[recessive model], p = 0.54; OR 1.05; 95% CI 0.89-1.24 for males and 32.1% vs 29.7% carriers of the minor T allele, p = 0.28; OR 1.12; 95% CI 0.91-1.37 for females) PMID: 29264877
    2. Results discovered for the first time that MRAS is recurrently mutated, indicating that MRAS mutations could drive tumorigenesis of Type IV gastric neoplasm. PMID: 27891760
    3. The association of the MARS rs6782181 polymorphism and serum lipid levels is different between the Mulao and Han populations, or between males and females in the both ethnic groups. PMID: 25973078
    4. The MRAS gene loci might have a minor effect in conferring susceptibility to coronary artery disease in the Chinese population. PMID: 25800439
    5. Both MRAS and SHOC2 play a key role in polarized migration. PMID: 24211266
    6. implicated in a novel pathway of neuronal differentiation by coupling specific trophic factors to the MAPK cascade through the activation of B-Raf PMID: 12138204
    7. These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1, mediated by RA-GEF-2, in adhesion signaling. PMID: 17538012
    8. Identification of one new CAD risk locus on 3q22.3 in MRAS, and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43. PMID: 19198612

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Expression highly restricted to the brain and heart.
  • 数据库链接：

    HGNC: 7227

    OMIM: 608435

    KEGG: hsa:22808

    STRING: 9606.ENSP00000289104

    UniGene: Hs.527021

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