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  4. MUC17 Recombinant Monoclonal Antibody

MUC17 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    MUC17重组抗体
  • 货号：
    CSB-RA727848MA1HU
  • 规格：
    ￥1320
  • 图片：
    • The Binding Activity of Human MUC17 with Anti-MUC17 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MUC17 (CSB-MP727848HU) at 2 μg/mL can bind Anti-MUC17 recombinant antibody. The EC50 is 0.9057-1.259 ng/mL.
    • The purity of MUC17 was greater than 95% as determined by SEC-HPLC
  • 其他：

产品详情

  • 产品描述：
    CSB-RA727848MA1HU MUC17重组单克隆抗体是经ELISA验证的高特异性科研工具，靶向黏蛋白家族成员MUC17。该跨膜糖蛋白在胃肠道上皮屏障保护和细胞信号调控中发挥重要作用，其异常表达与消化系统病理过程密切相关。本抗体通过重组技术制备，具备优异的重现性和批次稳定性，适用于定量ELISA检测体系，可精准识别天然构象的MUC17蛋白。实验数据显示其在抗原识别中展现高亲和力与低交叉反应性，能够有效支持基础研究中的蛋白表达水平分析、病理机制探索及相关信号通路研究。该产品特别适用于胃肠道疾病模型构建、肿瘤微环境分析以及黏蛋白功能组学研究，为探讨MUC17在细胞黏附、分化及免疫调节中的作用提供可靠检测工具，满足分子互作研究和生物标志物筛选等科研需求。
  • Uniprot No.：
    Q685J3
  • 基因名：
    MUC17
  • 别名：
    Mucin-17, MUC-17, Small intestinal mucin-3 (MUC-3), MUC17, MUC3
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human MUC17 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Human IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    8D12
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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MUC17 Proteins

靶点详情

  • 功能：
    Probably plays a role in maintaining homeostasis on mucosal surfaces.
  • 基因功能参考文献：
    1. MUC17 polymorphisms are involved in endometriosis development and the associated infertility in the Taiwanese population. PMID: 26285705
    2. Carbachol stimulated enterocyte MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment. PMID: 23784542
    3. The HIF1alpha-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of hypoxia responsive element could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells. PMID: 22970168
    4. Both native and exogenous MUC17 play a role in attachment and invasion of enteroinvasive E. coli in colonic cell lines and in maintaining epithelial barrier function. PMID: 21393431
    5. Hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of Pancreatic ductal adenocarcinomas. PMID: 20926598
    6. Results indicate that the potential protective effects of this membrane-bound mucin are primarily or secondarily diminished in inflammatory and neoplastic conditions. PMID: 20702471
    7. augments intestinal cell restitution and enhances healing of experimental colitis in mice PMID: 20211273
    8. The authors demonstrate that apically atypical enteropathogenic Escherichia coli infection is followed by increased production of secreted MUC2 and MUC5AC mucins and membrane-bound MUC3 and MUC4 mucins. PMID: 20065027
    9. sequence homology & chromosome mapping PMID: 11855812
    10. surface localization of the smaller subunit of MUC17 is dependent on its N-glycosylation status PMID: 12888891
    11. The MUC17 sequence has been extended toward its 5'-extremity to complete the sequence and localize the promoter and regulatory elements. PMID: 16737958
    12. Pdzk1 plays a specific role in stabilizing Muc17 in the apical membrane of small intestinal enterocytes. PMID: 17990980

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Secreted. Cell membrane.
  • 组织特异性：
    Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in panc
  • 数据库链接：

    HGNC: 16800

    OMIM: 608424

    KEGG: hsa:140453

    STRING: 9606.ENSP00000302716

    UniGene: Hs.271819

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