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  4. PRKAG1 Recombinant Monoclonal Antibody

PRKAG1 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    PRKAG1重组抗体
  • 货号：
    CSB-RA161743A0HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA161743A0HU diluted at 1:100 and staining in paraffin-embedded human Prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    CSB-RA161743A0HU PRKAG1重组单克隆抗体是针对AMP激活蛋白激酶γ1亚基（PRKAG1）研发的高特异性科研工具。该抗体靶向的PRKAG1作为AMPK复合物的关键调控组分，在细胞能量代谢平衡、糖脂代谢调控及应激响应中发挥核心作用，其功能异常与代谢性疾病及心血管疾病的发生发展密切相关。本产品经严格验证，在ELISA和免疫组化（IHC）实验中展现优异性能，特别适用于石蜡包埋组织样本的检测，推荐使用稀释比例为1:50-1:200时可获得清晰的特异性信号。该抗体适用于探究能量代谢相关信号通路机制、疾病模型中的蛋白表达定位研究，以及代谢综合征、心肌肥厚等病理过程的分子机制解析，为细胞代谢调控、疾病生物标志物筛选等基础研究领域提供可靠检测方案。
  • Uniprot No.：
    P54619
  • 基因名：
    PRKAG1
  • 别名：
    5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg), PRKAG1
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human PRKAG1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    5E5
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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PRKAG1 antibodies

靶点详情

  • 功能：
    AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling...显示更多
  • 基因功能参考文献：
    1. Data suggest different gamma-isoforms in AMPK can have different effects on enzyme activation; here, activation of AMPK by compound 991 is greater if AMPK contains PRKAG2 versus PRKAG1 or PRKAG3. PMID: 28302767
    2. Pin1 plays an important role in the pathogenic mechanisms underlying impaired glucose and lipid metabolism, functioning as a negative regulator of AMPK PMID: 26276391
    3. Letter: report PRKAG1 frameshift mutations in colorectal cancer. PMID: 25267969
    4. Electrogenic phosphate transport in sodium/phosphate cotransporter NaPi-IIa-expressing Xenopus oocytes is markedly decreased by the coexpression of constitutively active AMPKgammaR70Q, but not of AMPK(alphaK45R). PMID: 24356547
    5. PRKAG1 interacts with DSCAM through its gamma subunit, and netrin-1 activates AMPK phosphorylation in cortical neurons. PMID: 23479427
    6. Conclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac function. PMID: 22456184
    7. Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells. PMID: 19052260

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  • 蛋白家族：
    5'-AMP-activated protein kinase gamma subunit family
  • 数据库链接：

    HGNC: 9385

    OMIM: 602742

    KEGG: hsa:5571

    STRING: 9606.ENSP00000323867

    UniGene: Hs.530862

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