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  4. SCIN Recombinant Monoclonal Antibody

SCIN Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    SCIN重组抗体
  • 货号：
    CSB-RA213020A0HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA213020A0HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    SCIN Recombinant Monoclonal Antibody（CSB-RA213020A0HU）是针对SCIN（Scinderin）蛋白开发的小鼠源重组单克隆抗体，适用于ELISA和免疫组化（IHC）等实验场景。SCIN蛋白是一种钙依赖性肌动蛋白切割调控因子，通过调节细胞骨架动态变化参与胞吐作用、细胞迁移和免疫应答等生物学过程，其表达异常与肿瘤转移、神经系统疾病及免疫功能障碍密切相关。本抗体经严格验证，在IHC实验中可特异性识别石蜡包埋组织样本中的SCIN抗原，推荐使用稀释比例为1:50-1:200，实验数据显示其在多种组织切片中呈现清晰的胞质定位染色信号，背景干扰低，重复性良好。该产品适用于探究SCIN在肿瘤微环境中的调控机制、细胞骨架重塑相关疾病模型研究以及免疫细胞功能分析等科研领域，为细胞运动、分泌机制及病理状态下的分子机制研究提供可靠工具。
  • Uniprot No.：
    Q9Y6U3
  • 基因名：
    SCIN
  • 别名：
    Adseverin (Scinderin), SCIN, KIAA1905
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human SCIN
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    12B11
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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SCIN antibodies

SCIN Proteins

靶点详情

  • 功能：
    Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regul...显示更多
  • 基因功能参考文献：
    1. Data suggest that scinderin (Scin) played a vital role in the development of developmental dysplasia of the hip (DDH). PMID: 28213129
    2. Epistasis analysis identified a statistically significant interaction between CDC42 and SCIN SNPs which are strongly associated with CDC42 and SCIN gene expression levels and map to regulatory elements in skin cells. This interaction has important biological relevance since CDC42 and SCIN proteins have opposite effects in actin cytoskeleton organization and dynamics, which underlies melanoma cell migration and invasion. PMID: 27347659
    3. High levels of SCIN expression in gastric cancer tissue correlate with poor prognosis of patients. SCIN enhances the invasion and metastasis of GC cells through activating the Cdc42 pathway to increase the formation of filopodia. PMID: 27033455
    4. Suppression of scinderin impairs proliferation and migration of gastric cancer SGC7901 cells and attenuates its epithelialmesenchymal transition process. PMID: 25174406
    5. SCIN plays an important role in lung carcinoma cell proliferation PMID: 25303873
    6. These results suggest that SCIN plays an important role in the proliferation of prostate cancer cells and lentivirus-mediated inhibition of SCIN expression may be a potential therapeutic method for the treatment of prostate cancer PMID: 24212916
    7. Scinderin expression does not correlate with prognosis in head and neck cancer. PMID: 24330498
    8. calcium binding to the N terminus of adseverin dominates the activation process to expose the F-actin binding site on A2 PMID: 19666531

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, podosome.
  • 蛋白家族：
    Villin/gelsolin family
  • 组织特异性：
    Expressed in megakaryocytes.
  • 数据库链接：

    HGNC: 21695

    OMIM: 613416

    KEGG: hsa:85477

    STRING: 9606.ENSP00000297029

    UniGene: Hs.633359

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