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  4. STK33 Recombinant Monoclonal Antibody

STK33 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    STK33重组抗体
  • 货号：
    CSB-RA207790A0HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA207790A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    STK33重组单克隆抗体（产品编号CSB-RA207790A0HU）是针对丝氨酸/苏氨酸蛋白激酶33（STK33）研发的高特异性抗体。STK33是一种参与细胞周期调控、DNA损伤修复及细胞凋亡的关键信号分子，其异常表达与多种肿瘤发生发展密切相关。本抗体通过重组表达技术制备，经ELISA和免疫组化（IHC）严格验证，在IHC应用中推荐使用1:50-1:200稀释比例，可清晰定位目标蛋白在细胞质或细胞核中的表达分布，实验结果显示其具备高亲和力与低交叉反应性，能够有效识别天然及重组STK33蛋白。该产品适用于癌症发生机制研究、细胞增殖与凋亡相关信号通路分析，以及蛋白功能验证等科研领域，为探索STK33在肿瘤微环境调控、治疗靶点筛选等方向提供可靠工具。
  • Uniprot No.：
    Q9BYT3
  • 基因名：
    STK33
  • 别名：
    Serine/threonine-protein kinase 33 (EC 2.7.11.1), STK33
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human STK33
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    5H11
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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STK33 antibodies

STK33 Proteins

靶点详情

  • 功能：
    Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME. Not essential for the survival of KRAS-dependent AML cell lines.
  • 基因功能参考文献：
    1. Dysregulated HIF1alpha/STK33 signaling promotes pancreatic ductal adenocarcinoma (PDAC) growth and progression, this suggests that STK33 is a candidate therapeutic target to improve PDAC treatment. PMID: 29038348
    2. STK33 is a potential oncogene and plays an important role in tumorigenesis of HSCC via regulation of numerous genes. PMID: 27414193
    3. STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity. PMID: 25398772
    4. Results show that STK33 is a potential oncogene and a promising diagnostic marker for hypopharyngeal squamous cell carcinoma (HSCC). STK33 may promote tumorigenesis and progression of HSCC, and serve as a valuable molecular target for treatment of HSCC. PMID: 25603720
    5. STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 large cell lung cancer cell lines. In addition, this protein also promotes epithelial-mesenchymal transition. PMID: 25662617
    6. The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children. PMID: 23967198
    7. STK33 downregulation or dominant mutant overexpression had no effect on KRAS signaling or survival of cancer cells. PMID: 21742770
    8. STK33/Stk33 expression pattern resembles those of some related members of the calcium/calmodulin dependent kinase group PMID: 16176263

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  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
  • 组织特异性：
    Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophag
  • 数据库链接：

    HGNC: 14568

    OMIM: 607670

    KEGG: hsa:65975

    STRING: 9606.ENSP00000320754

    UniGene: Hs.501833

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