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XPNPEP1 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    XPNPEP1重组抗体
  • 货号：
    CSB-RA878859MA1HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA878859MA1HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing JK cells stained with CSB-RA878859MA1HU (red line) at 1:300. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*106cells) used under the same conditions. Acquisition of >10,005 events was performed.
  • 其他：

产品详情

  • 产品描述：
    CSB-RA878859MA1HU XPNPEP1重组单克隆抗体是针对氨肽酶P（XPNPEP1）靶点开发的高特异性科研工具。该抗体通过重组技术制备，具有批次稳定性和高亲和力，经ELISA、免疫组化（IHC）及流式细胞术（FC）多平台验证，在推荐稀释比例范围内（IHC 1:20-1:200，FC 1:20-1:200）表现出优异的目标蛋白结合能力。XPNPEP1作为细胞外基质调节酶，参与血管紧张素、缓激肽等活性肽的代谢调控，在心血管稳态和肾脏功能研究中具有重要价值。本产品适用于体外培养细胞或组织样本中XPNPEP1的定位检测及表达水平分析，可支持血管生物学、代谢性疾病机制、药物靶点筛选等基础研究领域。其单克隆特性确保实验数据的高度可重复性，特别适用于需要长期追踪蛋白动态变化的实验体系，为探索XPNPEP1在细胞信号传导及病理生理过程中的功能提供可靠工具。
  • Uniprot No.：
    Q9NQW7
  • 基因名：
    XPNPEP1
  • 别名：
    Aminoacylproline aminopeptidase antibody; aminopeptidase P, cytosolic antibody; APP1 antibody; Cytosolic aminopeptidase P antibody; RP11 451M19.1 antibody; sAmp antibody; Soluble aminopeptidase P antibody; soluble antibody; X Pro aminopeptidase 1 antibody; X prolyl aminopeptidase (aminopeptidase P) 1 antibody; X prolyl aminopeptidase (Aminopeptidase P) 1 soluble antibody; X prolyl aminopeptidase 1 antibody; X prolyl aminopeptidase 1 soluble antibody; X-Pro aminopeptidase 1 antibody; X-prolyl aminopeptidase 1 antibody; Xaa Pro aminopeptidase 1 antibody; Xaa-Pro aminopeptidase 1 antibody; XPNPEP 1 antibody; XPNPEP antibody; xpnpep1 antibody; XPNPEPL antibody; XPNPEPL1 antibody; XPP1_HUMAN antibody
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human XPNPEP1 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Mouse IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    4D12
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, FC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    FC 1:20-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
    Flow cytometry (FC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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XPNPEP1 antibodies

XPNPEP1 Proteins

靶点详情

  • 功能：
    Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
  • 基因功能参考文献：
    1. Alanine replacement of Arg535 destabilizes the AMPP dimer and guanidine hydrochloride restores the native monomer-dimer equilibrium. It is proposed that Arg535 plays an important role in AMMP catalysis and in stabilization of the catalytically active dimeric state PMID: 29351301
    2. These data suggest that progesterone-induced increases in AP-P may contribute to the development of oral contraceptive pill-induced hypertension in susceptible Women. PMID: 19126663
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase M24B family
  • 组织特异性：
    Expressed in all tissues tested, including pancreas, heart, muscle, kidney, liver, lung and brain. Highest levels in pancreas.
  • 数据库链接：

    HGNC: 12822

    OMIM: 602443

    KEGG: hsa:7511

    STRING: 9606.ENSP00000421566

    UniGene: Hs.390623

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