PRKCQ Recombinant Monoclonal Antibody

1. The Pro(168) residue in the C1a domain of full length PKCtheta; plays a critical role in the ligand and membrane binding, while exchanging the residue (Lys(240)) at the same position in C1b domain of full length PKCtheta; only modestly reduced the membrane interaction. PMID: 29317197
2. PKC-theta; is strongly and exclusively expressed in GISTs and interacts with intracellular mutant KIT to promote its stabilization by increased retention in the Golgi complex. PKC-theta; plays critical roles in the sustained activation of MT-KITs. Overexpression of PKC-theta; significantly correlates with several clinicopathological parameters PMID: 27440273
3. PCR and transcriptome analysis suggest that the genes CD3D and PKRCQ together can be used as a model for differentiating between B-cell and T-cell acute lymphoblastic leukemia. PMID: 27494091
4. PKC-theta; is a critical factor for type 2 innate lymphoid cells activation that contributes to TH2 cell differentiation, which is associated with IRF4 and NFAT1 expression in allergic lung inflammation. PMID: 27746240
5. Enhanced PRKCQ/PKCtheta; expression can promote growth-factor-independent growth, anoikis resistance, and migration. PRKCQ critically regulates growth and survival of a subset of TNBC. PMID: 27663795
6. Data suggest that, in T-lymphocytes, nitric oxide generated by eNOS S-nitrosylates Cys374 on ACTB and thus regulates activation/recruitment of PRKCQ at immune synapse; S-nitrosylation of beta-actin impairs actin binding to PFN1 and regulates protein transport in lamellipodia. (eNOS = nitric oxide synthase 3; ACTB = beta-actin; PRKCQ = protein kinase C-theta; PFN1 = profilin-1) PMID: 28394935
7. PKCtheta;-induced phosphorylations control the ability of Fra-1 to stimulate gene expression and breast cancer cell migration. PMID: 27816489
8. Within the nucleus, PKC-theta; catalytic activity maintains the Ser536 phosphorylation on the p65 subunit of NF-kappaB (also known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition. PMID: 27149922
9. Data show that tonantzitlolone (TZL) was able to induce protein kinase c theta (PKCtheta;)-dependent heat shock transcription factor 1 (HSF1)phosphorylation. PMID: 26298773
10. The PRKCQ polymorphism is not associated with Behcet's Disease. PMID: 26784953
11. Sumoylation of PKC-theta; was essential for T cell activation. Desumoylation did not affect the catalytic activity of PKC-theta; but inhibited the association of CD28 with PKC-theta; and filamin A and impaired the assembly of a mature immunological synapse. PMID: 26390157
12. Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation. PMID: 25889880
13. PKCtheta; acts through the activation of p38 MAPK and autophagy induction. PKCtheta; acts through the activation of p38 MAPK and autophagy induction to induce the Epstein-Barr virus (EBV) lytic cycle. PMID: 25827954
14. Data suggest that protein kinase C theta (PKCtheta;) inhibition alone may be sufficient to drive efficacy in chronic autoimmune and inflammatory diseases. PMID: 25000588
15. responsive to chemokine induced migration and are defective in migration to lymph nodes. Our results reveal a novel role for PKCtheta; in regulating T cell migration PMID: 24250818
16. protein kinase C-theta promotes Epithelial to mesenchymal transition by acting as a critical chromatin-anchored switch for inducible genes via transforming growth factor beta and the key inflammatory regulatory protein NF-kappaB. PMID: 24891615
17. Diacylglycerol activation of protein kinase Ctheta; and subsequent impairment of insulin signaling plays a major role in the pathogenesis of muscle insulin resistance in humans. PMID: 24979806
18. The results show that PKC-theta; has important diagnostic significance in gastrointestinal stromal tumors. PMID: 23862765
19. Results show that T allele of rs500766 in PRKCQ was associated with a reduced risk of ACE inhibitor-associated angioedema in the Nashville/Marshfield sample and ONTARGET. PMID: 23838604
20. This is the first study that shows that the activity of PKC-theta; is regulated by the intracellular redox state, and that PKC-theta; is recruited to the plasma membrane in an inactive form in naive T cells. PMID: 23436678
21. PRKCQ is the only T cell-expressed protein kinase C that localizes selectively to center of immunological synapse following T cell antigen stimulation; this unique localization is essential for PRKCQ-mediated downstream signaling. [REVIEW] PMID: 23433459
22. Protein kinase C-theta (PKCtheta;) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin. PMID: 23509302
23. The emerging role of protein kinase Ctheta; in cytoskeletal signaling. PMID: 23192428
24. These results reveal key functional roles for PKC-theta and ROS in T cell acute lymphoblastic leukemia and suggest that aggressive biological behavior in vivo could be limited by therapeutic strategies that promote PKC-theta expression or activity PMID: 23086478
25. PKCtheta signalling as an important regulator of Fra-1 accumulation in estrogen receptor positive breast cancer cells. PMID: 22286759
26. establish the C2 domain of PKCtheta; as a Tyr(P)-binding domain and suggest that the domain may play a major role in PKCtheta; activation via its Tyr(P) binding. PMID: 22787157
27. alterations in nPKC location and increased expression of PKC theta observed is a result of modification of PKC-mediated signal transduction and cell function PMID: 22905394
28. AMPK regulates expression of FASL and COX-2 via the protein kinase C theta - dependent pathway in activated Jurkat cells. PMID: 22330070
29. Interleukin-1beta-induced decrease in transendothelial electrical resistance is prevented by small hairpin RNA silencing of PKC-Theta. PMID: 22403784
30. TLR-dependent TRAF6-MKK3-p38 MAPK signaling pathway synergizes with PKCtheta;-MEK-ERK signaling pathway. CARMA1 plays a crucial role in mediating this synergistic effect via TRAF6. PMID: 22303480
31. The most sensitive marker for gastrointestinal stromal tumors was CD117, followed by DOG-1 and PKCtheta. PMID: 22197035
32. c-KIT, PKC-theta; and DOG-1 antigens are the most sensitive and specific immunomarkers for confirming EGISTs PMID: 22399613
33. High nuclear protein kinase C theta expression may correlate with disease recurrence and poor survival in oral squamous cell carcinoma. PMID: 21840039
34. Protein kinase C-theta in platelet activation PMID: 21944869
35. both DOG1 and PKC-theta; can be used in the diagnosis of KIT-negative GISTs PMID: 21358619
36. PRKCQ is regulated by RUNX1 in megakaryocytes and platelets, and provide an explanation for the decreased PKC-theta expression in RUNX1 haplodeficiency. PMID: 21252065
37. Results provide a molecular explanation for the role of PKC-theta; not only in normal T cell function, but also in circumstances of its ectopic expression in cancer. PMID: 21419345
38. In TRAIL costimulation, lipid raft recruitment of Lck tyrosine kinase integrates mitogenic NF-kappaB-dependent signals from the T cell receptor and TRAIL in T lymphocytes. PMID: 21160038
39. Reduced expression of PKCtheta is well correlated with the grade of human hepatocellular carcinoma cancer cells PMID: 19949911
40. Compared with CD117, DOG1 (using the K9 antibody) is a more specific marker, whereas PKC theta (using the clone 27 antibody) is a considerably less specific immunohistochemical marker for GIST. PMID: 20716167
41. STudies indicate that in regulatory T cells, PKC-theta inhibits their function and, intriguingly, is sequestered from the activating cellular interface. PMID: 20664063
42. ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta PMID: 20472553
43. The protein kinase C theta transduction pathway is identified as a main regulator of the NKG2D-mediated costimulation of antitumor Vgamma9Vdelta2 cytolytic T cell responses. PMID: 20511557
44. Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors. PMID: 18521081
45. formation of immunological synapse(IS) induces altered signal pathways in Treg, characterized by reduced recruitment of Src kinases, PKC-theta & Carma-1 to the IS; in Treg, PKC-theta acts as a proinflammatory mediator & this effect is enhanced by TNFalpha PMID: 20339032
46. Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets PMID: 11788586
47. Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C PMID: 11956228
48. PKC theta functions as a positive modulator of calcineurin-regulated retinoid X receptor responsive element-dependent transcription during T cell activation. PMID: 12097375
49. PKC theta is rapidly and persistently activated in gamma delta T cells by the mycobacterial phosphoantigen isopentenyl pyrophosphate, as determined by evidence of translocation and phosphorylation. PMID: 12421956
50. T cell activation silences nuclear receptor-dependent transactivation in part through PKC theta-dependent enhancement of silencing mediator of retinoic acid and thyroid hormone receptors (SMRT)-receptor interaction. PMID: 12890684

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HGNC: 9410

OMIM: 600448

KEGG: hsa:5588

STRING: 9606.ENSP00000263125

UniGene: Hs.498570