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  4. Recombinant Bovine High mobility group protein B1 (HMGB1)

Recombinant Bovine High mobility group protein B1 (HMGB1)

  • 中文名称：
    牛HMGB1重组蛋白
  • 货号：
    CSB-YP010553BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛HMGB1重组蛋白
  • 货号：
    CSB-EP010553BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛HMGB1重组蛋白
  • 货号：
    CSB-EP010553BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛HMGB1重组蛋白
  • 货号：
    CSB-BP010553BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛HMGB1重组蛋白
  • 货号：
    CSB-MP010553BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HMGB1
  • Uniprot No.：
    P10103
  • 别名：
    HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-215
  • 氨基酸序列
    GKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEEEEE DDDDE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplas...显示更多
  • 基因功能参考文献：
    1. HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations. PMID: 26639899
    2. Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis. PMID: 22875364
    3. The mechanisms of interaction of the non-histone chromosomal protein HMGB1 and linker histone H1 with DNA have been studied using circular dichroism and absorption spectroscopy. PMID: 21634123
    4. HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low PMID: 21473120
    5. Interaction between non-histone chromatin protein HMGB1 and linker histone H1 PMID: 21268854
    6. HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation. PMID: 20659415
    7. Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration. PMID: 15504049
    8. Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin. PMID: 18599803

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  • 亚细胞定位：
    Nucleus. Chromosome. Cytoplasm. Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Endosome. Endoplasmic reticulum-Golgi intermediate compartment.
  • 蛋白家族：
    HMGB family
  • 数据库链接：

    KEGG: bta:282691

    STRING: 9913.ENSBTAP00000024094

    UniGene: Bt.49650

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