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  4. Recombinant Bovine RAS guanyl-releasing protein 2 (RASGRP2), partial

Recombinant Bovine RAS guanyl-releasing protein 2 (RASGRP2), partial

  • 中文名称：
    牛RASGRP2重组蛋白
  • 货号：
    CSB-YP019363BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛RASGRP2重组蛋白
  • 货号：
    CSB-EP019363BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛RASGRP2重组蛋白
  • 货号：
    CSB-EP019363BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛RASGRP2重组蛋白
  • 货号：
    CSB-BP019363BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛RASGRP2重组蛋白
  • 货号：
    CSB-MP019363BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RASGRP2
  • Uniprot No.：
    A6N9I4
  • 别名：
    RASGRP2; RAS guanyl-releasing protein 2; Calcium and DAG-regulated guanine nucleotide exchange factor I; CalDAG-GEFI
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
  • 基因功能参考文献：
    1. this amino acid substitution is likely responsible for the thrombopathic phenotype observed in Simmental cattle and underscores the critical nature of this signal transduction protein in platelets PMID: 18039909
  • 相关疾病：
    Defects in RASGRP2 may be the cause of Simmental thrombopathia. An inherited platelet disorder first described in Simmental cattle and characterized by mild to severe bleeding episodes.
  • 亚细胞定位：
    Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell projection, ruffle membrane; Peripheral membrane protein.
  • 蛋白家族：
    RASGRP family
  • 数据库链接：

    KEGG: bta:512056

    STRING: 9913.ENSBTAP00000001368

    UniGene: Bt.44411

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