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  4. Recombinant Chicken Fibroblast growth factor 8 (FGF8)

Recombinant Chicken Fibroblast growth factor 8 (FGF8)

  • 中文名称：
    鸡FGF8重组蛋白
  • 货号：
    CSB-YP845867CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鸡FGF8重组蛋白
  • 货号：
    CSB-EP845867CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鸡FGF8重组蛋白
  • 货号：
    CSB-EP845867CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鸡FGF8重组蛋白
  • 货号：
    CSB-BP845867CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鸡FGF8重组蛋白
  • 货号：
    CSB-MP845867CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FGF8
  • Uniprot No.：
    Q90722
  • 别名：
    FGF8Fibroblast growth factor 8; FGF-8; Heparin-binding growth factor 8; HBGF-8
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-214
  • 氨基酸序列
    QVTVQSPP NFTQHVREQS LVTDQLSRRL VRTYQLYSRT SGKHVQILDN KKINAMAEDG DVHAKLIVET DTFGSRVRIK GAATGFYICM NKKGKLIGKS NGKGKDCVFT EIVLENNYTA LQNAKYEGWY MAFTRKGRPR KGSKTRQHQR EVHFMKRLPK GHQTTEPHRR FEFLNYPFNR RSKRTRNSSA SLRP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs.
  • 基因功能参考文献：
    1. a precise and dynamic expression pattern of fibroblast growth factor 8 (Fgf8) was found in the high acuity area anlage, which was regulated by enzymes that degrade retinoic acid (RA). PMID: 28648799
    2. FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation. PMID: 26130757
    3. Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules PMID: 23201021
    4. Data show that ectopic FGF8 overexpression in the ventral pharynx of HH16-18 embryos caused a dramatic increase in thickness of the mesenchyme. PMID: 21419761
    5. sufficient, but not necessary, for ANTXR1 expression in Hamburger and Hamilton stage 18 facial mesenchyme PMID: 20034073
    6. FGF8 regulates embryonic limb development via WNT/b-catenin signaling PMID: 11290326
    7. When Irx2 is misexpressed with Fgf8 in the chick midbrain, the midbrain develops into cerebellum in conjunction with repression of Otx2 and induction of Gbx2. Signaling by FGF8 modulates the activity of Irx2 by phosphorylation. PMID: 15133517
    8. Fgf8 has a role in activating the Ras-ERK pathway and differentiation of cerebellum PMID: 15294862
    9. FGF8 and Shh have strong synergistic effects on chondrogenesis in vitro and promote outgrowth and chondrogenesis in vivo, suggesting a very specific role in producing elongated beak structures during chick facial development. PMID: 15302603
    10. Fgf8 plays a critical upstream role in an FGF signaling cascade required for otic induction PMID: 15741321
    11. genomic structure characterization of chick Fgf8 PMID: 16147873
    12. Results show that antagonistic signals from the neural tube and the branchial arches specify extraocular versus branchiomeric muscles, and that Fgf8 is the branchial arch derived signal. PMID: 16775000
    13. FGF8 triggered apoptosiss allow the formation of a roof plate progress zone at some distance from the FGF8 source. PMID: 16818448
    14. Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence PMID: 17988255
    15. FGF8b acts on the epiblast synergistically with Nodal at the pregastrula stage to induce smooth-muscle actin. It is likely that FGF8b is a candidate molecule secreted by hypoblast and regulates the heart mesoderm formation/early cardiomyogenesis. PMID: 18312428

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 数据库链接：

    KEGG: gga:396313

    STRING: 9031.ENSGALP00000038573

    UniGene: Gga.661

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