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  4. Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1), partial

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1), partial

  • 中文名称：
    人PLCE1重组蛋白
  • 货号：
    CSB-YP868386HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PLCE1重组蛋白
  • 货号：
    CSB-EP868386HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PLCE1重组蛋白
  • 货号：
    CSB-EP868386HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PLCE1重组蛋白
  • 货号：
    CSB-BP868386HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PLCE1重组蛋白
  • 货号：
    CSB-MP868386HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLCE1
  • Uniprot No.：
    Q9P212
  • 别名：
    1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase epsilon-1; Pancreas-enriched phospholipase C; Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1; PLC-epsilon-1; Plce1; PLCE1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formatio...显示更多
  • 基因功能参考文献：
    1. PLCE1 polymorphism is associated with Gastric and esophageal cancer. PMID: 30202044
    2. Study found that rs2274223 A>G in PLCE1 was associated with lower PLCE1 gene expression and increased gastric cancer (GC) survival. These findings support PLCE1 rs2274223 as a potential prognostic biomarker for GC survival. PMID: 29983348
    3. we report the functional characterization of a four-nucleotide insertion/deletion variation (rs71031566 C----/CATTT) in PLCE1 that was associated with risk of developing esophageal squamous cell carcinoma PMID: 29106514
    4. knockdown of expression of PLCe inhibits Prostate cancer cells proliferation via the PTEN/AKT signaling pathway. PMID: 29330357
    5. the results of the multiple bioinformatic analysis contributes to a systematic understanding of the roles of PLCE1 in esophageal squamous cell carcinoma . PMID: 28849204
    6. these results showed that the knockdown of PLCE1 may play a vital role in the control of esophageal squamous cell carcinoma. PMID: 29238898
    7. Our results demonstrate that PLCE1 haplotypes (including rs2274223 and rs3765524) and expression combined with serum AFP level may predict postoperative outcome of HBV-related HCC patients. PMID: 28418898
    8. high expression of both PLCE1 and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers. PMID: 28402280
    9. rs10882379 and rs829232 SNPs in the PLCE1 gene may contribute to the esophageal squamous cell carcinoma (ESCC) susceptibility in Chinese Han population. Also the gene-gene and gene-environment interactions play a certain crucial role in the ESCC progression. PMID: 27061010
    10. No association between PLCE1 genotype and early viremia level in dengue patients. PMID: 28599625
    11. PLCE1 single-nucleotide polymorphism is associated with migraine. PMID: 27322543
    12. PLCE1 expression was found in the invasive carcinoma but not in the carcinoma in situ samples. Snail expression in the human ESCC samples significantly correlated with the PLCE1 protein level, and expression of Snail target genes in human esophageal cancer samples were also correlated with the PLCE1 abundance. PMID: 28147304
    13. results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity PMID: 27612188
    14. High PLC epsilon expression is associated with breast cancer. PMID: 28112359
    15. The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients PMID: 27907007
    16. Two novel putatively deleterious PLCE1 variants were identified in children with steroid-resistant nephrotic syndrome. PMID: 28476686
    17. PLC-epsilon is a novel regulator of endothelial cell inflammation and vascular endothelial permeability. PMID: 27371732
    18. Taken together, our data highlight the pivotal role of miR-1976 in the progression of NSCLC. Thus, miR-1976 may be a potential prognostic marker and of treatment relevance for NSCLC progression intervention. PMID: 27063799
    19. this study presents the impact of a single nucleotide transition at SNPs associated with DSS on differential protein binding patterns with PLCE1 and MICB genes and on protein structure modification and their possible role in the pathogenesis of dengue shock syndrome PMID: 27038471
    20. Study shows that PLCE1 Rs2274223 variation was significantly associated with colorectal cancer risk while rs3765524 did not. PMID: 27383248
    21. Data show that microRNA miR-145 was identified as a potent repressor of phospholipase C epsilon 1 (PLCE1) expression by directly targeting the 3' untranslated regions (3'UTR) of PLCE1. PMID: 26657507
    22. Data suggest the role of the phospholipase C epsilon-Protein kinase D-PEA15 protein-ribosomal S6 kinase-IkappaB-NF-kappa B pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon. PMID: 27053111
    23. Genetic Variants of PLCE1 Gene are not Associated with Colorectal Cancer. PMID: 26320491
    24. In conclusion, our results suggest that miR-328 suppresses the survival of EC cells by regulating PLCE1 expression, which might be a potential therapeutic method for EC. PMID: 26773497
    25. Our results suggested that STAT3 phosphorylation is involved in PLCe-mediated inflammatory cytokine release PMID: 26156799
    26. a significantly increased stomach cancer risk was associated with PLCE1 SNP rs2274223 in a Han Chinese population. PMID: 25658482
    27. Studied six SNP loci: (rs2279115 of BCL2 gene, rs804270 of NEIL2 gene, rs909253 of LTA gene, rs2294008 of PSCA gene, rs3765524 and rs10509670 of PLCE1 gene) to evaluate gastric cancer risk using magnetic nanoparticles and universal tagged arrays. PMID: 26554163
    28. This meta-analysis demonstrated that PLCE1 rs2274223 A > G polymorphism may be associated with increased susceptibility to cancer, especially for ESCC. PMID: 25614244
    29. PLCE1 gene rs2274223 polymorphism is associated with esophageal cancer PMID: 25854357
    30. variation in PLCE1 may be associated with GC risk in Kashmir Valley. PMID: 25434319
    31. The meta-analysis suggested that upregulated PLCE1 is significantly associated with an increased risk of tumor progression in esophageal squamous cell carcinoma and gastric cardia adenocarcinomas. PMID: 25520085
    32. PLCE1 rs2274223 polymorphism may be used as a potential biomarker for digestive tract cancer susceptibility particularly for esophageal squamous cell carcinoma and gastric cardia adenocarcinomas in the Chinese population. PMID: 24874112
    33. PLCE1 rs2274223 polymorphism is associated with esophageal cancer. PMID: 25422186
    34. The rs2274223 polymorphism in phospholipase C epsilon 1 was associated with an increased risk of esophageal squamous cell carcinoma in this Korean population PMID: 24152165
    35. Dysregulated PLCE1 mRNA expression was observed for both esophageal squamous cell carcinoma and gastric cancer PMID: 24867265
    36. Genetic variations in PLCE1 modulate risk of esophageal cancer in the high risk Kashmiri population. PMID: 24935391
    37. a new pathway for TRPC6 activation by Phospholipase C epsilon PMID: 25521631
    38. PLCE1 rs7922612CT + TT is associated with susceptibility of esophageal cancer. PMID: 25139097
    39. findings demonstrate that the presence of the G allele at rs2274223 of the PLCE1 gene may contribute to susceptibility to GC, especially cardia GC. PMID: 24985593
    40. PLCE1 gene silencing by RNAi resulted in decreased expression of cyclin D1. PMID: 25041015
    41. Meta-analysis suggested the PLCE1 rs2274223 might act as a cancer risk factor among all subjects, especially in the Chinese population and upper aerodigestive tract cancer. PMID: 24595086
    42. Data show that phospholipase C epsilon 1 (PLCE1) and liver X receptor-beta (LXR-beta) network interactions as important contributory factors for genetic predisposition in gallbladder cancer. PMID: 24863943
    43. NSCLC cells express high levels of PLCE1, which suppresses the expression of p53 in NSCLC cells. PMID: 24357048
    44. the PLCE1 rs2274223 A > G change might reduce gene expression and the variant genotype might contribute to the increased risk of colorectal cancer. PMID: 24496148
    45. Knockdown of PLCepsilon gene potently suppressed the nuclear factor kappa (NF-kappaB) signaling pathway. PMID: 24510280
    46. This meta-analysis provides strong statistical evidence for an elevated risk of EC associated with PLCE1 rs2274223 PMID: 24737582
    47. heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations. PMID: 24127316
    48. PKCalpha/beta is critical for PLCepsilon-mediated cancer cell invasion and migration PMID: 24316392
    49. Knockdown of PLCE1 markedly increased 9.26 folds of the expression of p53 and 13.8 folds of the frequency of apoptotic CP-C cells via modulating the p53 promoter methylation PMID: 24766303
    50. PLCepsilon1 shRNA depressed the in vitro and in vivo growth of gastric cancer cells by using MTT assay and tumor xenograft experiment. PMID: 24796667

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  • 相关疾病：
    Nephrotic syndrome 3 (NPHS3)
  • 亚细胞定位：
    Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Cell projection, lamellipodium. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.
  • 组织特异性：
    Widely expressed. Expressed in podocytes.; [Isoform 1]: Broadly expressed and only absent in peripheral blood leukocytes.; [Isoform 2]: Specifically expressed in placenta, lung and spleen.
  • 数据库链接：

    HGNC: 17175

    OMIM: 608414

    KEGG: hsa:51196

    STRING: 9606.ENSP00000260766

    UniGene: Hs.655033

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