Your Good Partner in Biology Research

中文简体

CSF2｜ CTLA4｜ DLL3｜ EGFR｜ IL4｜ IL4R｜ LAG3｜ MSTN｜ NECTIN4｜ NT5E｜ SEZ6｜ TM4SF1｜ TNFSF13｜ TPO

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Collagen alpha-1 (VI) chain (COL6A1), partial

Recombinant Human Collagen alpha-1 (VI) chain (COL6A1), partial

  • 中文名称：
    Recombinant Human Collagen alpha-1(VI) chain(COL6A1) ,partial
  • 货号：
    CSB-YP005751HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Collagen alpha-1(VI) chain(COL6A1) ,partial
  • 货号：
    CSB-EP005751HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Collagen alpha-1(VI) chain(COL6A1) ,partial
  • 货号：
    CSB-EP005751HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Collagen alpha-1(VI) chain(COL6A1) ,partial
  • 货号：
    CSB-BP005751HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Collagen alpha-1(VI) chain(COL6A1) ,partial
  • 货号：
    CSB-MP005751HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    COL6A1
  • Uniprot No.：
    P12109
  • 别名：
    Alpha 1 (VI) chain (61 AA); CO6A1_HUMAN; COL6A1; COL6A2; COL6A3; collagen 6; Collagen alpha 2(VI) chain; Collagen alpha 3(VI) chain; Collagen alpha-1(VI) chain; collagen six; Collagen type VI alpha 1; Collagen type VI alpha 2; Collagen type VI alpha 3; Collagen VI alpha 1 polypeptide; Collagen VI alpha 2 polypeptide; Collagen VI alpha 3 polypeptide; CollagenVI; Human mRNA for collagen VI alpha 2 C terminal globular domain; OPLL; PP3610
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

相关产品

COL6A1 antibodies

COL6A1 ELISA kits

靶点详情

  • 功能：
    Collagen VI acts as a cell-binding protein.
  • 基因功能参考文献：
    1. FKBP10 interacts with collagen VI and deficiency of FKBP10 reduces lung fibroblast migration by down-regulation of collagen VI synthesis. PMID: 29673351
    2. Five SNPs in the COL6A1 (and IL17RC) genes were found to be associated with susceptibility to ossification of the posterior longitudinal ligament in Han Chinese patients. PMID: 29764467
    3. the donor splice site of COL6A1 intron 14, associated with the phenotype of Bethlem myopathy or intermediate form, is a hot spot for ColVI myopathies PMID: 28984114
    4. The polypeptide is a novel non-triple helical polypeptide of type VI collagen alpha1 chain encoded by COL6A1, or NTH alpha1(VI). PMID: 29659864
    5. Missense mutations in COL6A1, COL11A2, FGFR1, and BMP2 genetically predispose patients to ossification of posterior longitudinal ligaments. PMID: 27246988
    6. We have used RNA-Seq to identify differentially expressed genes in cultured dermal fibroblasts from 13 COL6-RD individuals (8 dominant negative and 5 null) and 6 controls. To better assess the transcriptional changes induced by abnormal collagen VI in the extracellular matrix (ECM); we compared transcriptional profiles from subjects with DN mutations and subjects with null mutations to transcriptional profiles PMID: 29244830
    7. These data demonstrate, for the first time, a functional relationship between collagens VI and XII during osteogenesis. PMID: 26753503
    8. COL6A1 may have a role in progression and outcome of clear cell renal cell carcinoma PMID: 26317545
    9. upregulated in the airways of chronic obstructive pulmonary disease patients and exposed upon epithelial desquamation PMID: 25925694
    10. is the first report of UCMD recurrence in 2 siblings due to a germline mosaic COL6 gene mutation PMID: 25978941
    11. worsening of the functional disability appeared typically after the age of 40 in 47% of our patients with Bethlem myopathy, and was frequently associated with COL6A1 exon 14 skipping PMID: 25535305
    12. The second main finding of this study was that COL6A1 rs35796750 did not associate with the risk of anterior cruciate ligament injury in the self-reported Caucasian South African cohort. PMID: 25073002
    13. Type VI collagen and activated retinal Muller cells are present in iERM. PMID: 26447986
    14. Data indicate that collagen-VI-alpha-1 (COL6A1) is expressed in all grades of glioma. PMID: 25325876
    15. Data suggest the potential role of COL6 in promoting lung neoplasia in diseased lungs where COL6 is overexpressed. PMID: 25176343
    16. Parental mosaicism was confirmed in the four families through quantitative analysis of the ratio of mutant versus wild-type allele (COL6A1, COL6A2, and COL6A3) in genomic DNA from various tissues; consistent with somatic mosaicism, parental samples had lower ratios of mutant versus wild-type allele compared with the fully heterozygote offspring. PMID: 25204870
    17. In UCDM, 1 mutation was indentified in COL6A1 in Chinese patients. PMID: 24801232
    18. These results suggest that these SNPs of BMP-2 and COL6A1 may not directly influence the expression of OPLL. PMID: 24737472
    19. Absence of ANXA2 leads to retention of COL6 in a late-Golgi, VAMP2-positive compartment. PMID: 24357721
    20. Mutations in each of the three collagen VI genes, COL6A1, COL6A2 and COL6A3, cause four types of muscle disorders: Ullrich congenital muscular dystrophy, Bethlem myopathy, limb-girdle muscular dystrophy, and autosomal recessive myosclerosis. (Review) PMID: 24443028
    21. The resulting proposed clinical classification system of collagen VI-related myopathy is unique in that it is based on the integration of both motor function and pulmonary function criteria. PMID: 24271325
    22. XPD mutations in trichothiodystrophy hamper COL6A1 expression. PMID: 23221806
    23. TP-alpha, collagen alpha-1(VI) chain and S100A9 are potential biomarkers of esophageal squamous cell carcinoma, and may play an important role in tumorigenesis and development of ESCC. PMID: 22583932
    24. the COL6A1 rs35796750 TT genotype is associated with increased performance during the bicycling of the South African Ironman triathlon PMID: 22012643
    25. the accumulation of abnormal mitochondria and sarcoplasmic reticulum is caused by a defect of autophagy and that restoration of a proper autophagic flux in Col6a1-/- muscles ameliorates these alterations. PMID: 21037586
    26. This study revealed several genotype-phenotype correlations, providing new insights into the natural history and course of ColVI myopathies. PMID: 20976770
    27. COL6 genes encoding type VI collagen PMID: 11932968
    28. Haplotype analysis clearly suggested linkage of Ullrich muscular dystrophy to the COL6A1/2 locus in two cases and to the COL6A3 loci in the third case. In the remaining nine patients, primary collagen VI involvement was excluded PMID: 12011280
    29. Bethlem myopathy is an autosomal dominantly inherited myopathy with contractures caused by mutations in the COL6A1 gene. PMID: 12374585
    30. Collagen VI deficiency might have caused electron microscopic changes of capillaries, while function of capillaries is apparently retained. PMID: 12736748
    31. a de novo heterozygous deletion of the COL6A1 gene results in a severe phenotype of classical Ullrich congenital muscular dystrophy PMID: 12840783
    32. linkage disequilibrium and association studies that SNPs in the collagen 6A1 gene (COL6A1) were strongly associated with Ossification of the posterior longitudinal ligament PMID: 12958705
    33. The failure of collagen VI to anchor the basal lamina to the interstitium is the cause of Ullrich disease. PMID: 14981181
    34. dominant mutations are common in Ullrich congenital muscular dystrophy (UCMD). PMID: 15563506
    35. we report a genotype-phenotype correlation demonstrating that heterozygous glycine substitutions in the triple-helix domain of COL6A1 are dominant and responsible for a milder Ullrich scleroatonic muscular dystrophy phenotype. PMID: 16130093
    36. COL6A1 could be responsible for the hyperostotic state, leading to ectopic bone formation in the spinal ligament. PMID: 16227896
    37. beta ig-h3 can differentially modulate the aggregation of collagen VI with biglycan and decorin PMID: 16434404
    38. Major promoter and enhancer sequences regulating COL6A1 expression are present in this bacterial artificial chromosome clone. PMID: 17334655
    39. This study identified a novel homozygous COL6A1 premature termination mutation in a UCMD patient that causes nonsense-mediated mRNA decay. PMID: 17537636
    40. This study demonstrates a homogeneous overexpression of the genes encoding for alpha1 and alpha2 chains for collagen type VI in nuchal skin of human trisomy 21 fetuses. PMID: 17602442
    41. COL6A1 may be a common susceptibility gene for ossification of the ligamentum flavum and ossification of the posterior longitudinal ligament in Chinese Han population. PMID: 18246005
    42. Study reports 10 unrelated patients with a Ullrich congenital muscular dystrophy clinical phenotype and de novo dominant negative heterozygous splice mutations in COL6A1, COL6A2 and COL6A3. PMID: 18366090
    43. Immunofluorescent labeling of collagen VI in fibroblast cultures is a useful addition to current diagnostic services for Bethlem myopathy (BM). It can be used to guide molecular genetic testing in a cost-effective and time-saving manner. PMID: 18378883
    44. Results found COL6A1 to be differentially expressed in human astrocytomas. PMID: 18551403
    45. SNP of COL6A1 were not related to radiographic progression of ankylosing spondylitis. PMID: 18634150
    46. These data indicate that collagen VI glycine mutations impair the assembly pathway in different ways and disease severity correlates with the assembly abnormality. PMID: 18825676
    47. Four patients affected by Ullrich congenital muscular dystrophy and carrying unusual mutations of COL6 genes affecting RNA splicing, were identified. PMID: 19309692

    收起更多

  • 相关疾病：
    Bethlem myopathy 1 (BTHLM1); Ullrich congenital muscular dystrophy 1 (UCMD1)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Type VI collagen family
  • 数据库链接：

    HGNC: 2211

    OMIM: 120220

    KEGG: hsa:1291

    STRING: 9606.ENSP00000355180

    UniGene: Hs.474053

Most popular with customers

产品中心
特别关注


X