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  4. Recombinant Human Collagen alpha-1 (I) chain (COL1A1), partial

Recombinant Human Collagen alpha-1 (I) chain (COL1A1), partial

  • 中文名称：
    Recombinant Human Collagen alpha-1 (I) chain (COL1A1), partial
  • 货号：
    CSB-MP005727HU
  • 规格：
    ￥2376
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    COL1A1
  • Uniprot No.：
    P02452
  • 别名：
    Alpha-1 type I collagen
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    Mammalian cell
  • 分子量：
    33.8 kDa
  • 表达区域：
    334-389aa
  • 氨基酸序列
    PGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal hFc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Type I collagen is a member of group I collagen (fibrillar forming collagen).
  • 基因功能参考文献：
    1. results strengthen the evidence for the association between polymorphisms of -1997 G/T, +1245 G/T of the COL1A1 gene in the genetic etiology of keloid scars PMID: 27511505
    2. Structural basis of homo- and heterotrimerization of COL1A1/ COL1A2 has been reported. PMID: 28281531
    3. patients with OI have homogenously thinner corneas compared with controls, we observed that a collagen I chain mutation was not responsible for corneal curvature alterations in OI. PMID: 30272615
    4. Our findings demonstrate that collagen I could enhance the aggressive progression of residual hepatocellular carcinoma cells after suboptimal heat treatment and sorafenib may be a treatment approach to thwart this process. PMID: 30227844
    5. Cellular expression of COL1A1 could promote breast cancer metastasis. COL1A1 is a new prognostic biomarker and a potential therapeutic target for breast cancer, especially in ER+ patients. PMID: 29906404
    6. miR-129-5p level was decreased in fibrotic liver of human, and reduced by rOPN treatment. In contrast, miR-129-5p was induced in HSCs transfected by OPN siRNA. These data suggested that OPN induces Col 1 expression via suppression of miR-129-5p in hepatic stellate cells. PMID: 29196165
    7. Depletion of MRTF-A abolished the upregulation of COL1A1 in response to the TGF-beta or Wnt signaling. PMID: 29807221
    8. Mutations in the COL1A1 and COL1A2 genes associated with osteogenesis imperfecta (OI) types I or III. PMID: 29543922
    9. DNMT1 was downregulated in the Lung Cancer group and its expression was further reduced in the presence of increasing malignant burden as indicated by the endobronchial findings further suggesting an Lung Cancer-specific signature. PMID: 29568927
    10. our results indicated that COL1A1 promotes tumor metastasis, and that its inhibition may suppress CRC cell migration. In addition, the role of COL1A1 in CRC metastasis seems to be associated with the regulation of the WNT/PCP pathway. PMID: 29393423
    11. miR378b represses the mRNA expression levels of COL1A1 via interference with SIRT6 in human dermal fibroblasts. PMID: 28983623
    12. Exogenous proline stimulates type I collagen and HIF-1alpha expression and the process is attenuated by glutamine in human skin fibroblasts. PMID: 28526934
    13. the efficacy of pamidronate treatment does not seem to be related to the genotype of type I collagen in patients with osteogenesis imperfecta. PMID: 28528406
    14. High urine collagen is associated with renal dysfunction in lupus nephritis. PMID: 28339802
    15. MiR-133a-3p could inhibit the proliferation and migration of oral squamous cell carcinoma cells through directly targeting COL1A1 and reducing its expression. PMID: 28569392
    16. COL1A1 gene mutation is associated with osteogenesis imperfecta. PMID: 28810924
    17. Elevation of serum alpha1(I) collagen DNA levels in scleroderma patients may be useful as the diagnostic marker, reflecting the presence of vasculopathy. PMID: 28370352
    18. study showed that GG homozygotes were underrepresented in the ACL-rupture group compared with the control group, which suggests an association with reduced risk of anterior cruciate ligament injury PMID: 27632864
    19. Review/Meta-analysis: possible relationship between GG genotype of COL1A1 +1245G/T polymorphism and osteoporosis risk in post-menopausal women. PMID: 28261929
    20. These results support an activation mechanism of DDR1 whereby collagen induces lateral association of DDR1 dimers and phosphorylation between dimers. PMID: 28590245
    21. This study identified collagen gene sets related to self-reported depression scores in healthy participants. PMID: 28334615
    22. an endoplasmic reticulum complex of resident chaperones that includes HSP47, FKBP65, and BiP regulating the activity of LH2. PMID: 28177155
    23. Although serum procollagen type-1 N-terminal propeptide (PINP) levels were not found to be different, tartrate-resistant acid phosphatase type 5b isoform (TRACP 5b) levels were significantly higher in the control group. PMID: 27840329
    24. mutations of the COL1A1 and COL1A2 genes probably underlie the disease in the four families PMID: 28981938
    25. Our results indicated that COL1A1 rs1800012 polymorphism may be associated with the reduced risk of sports-related tendon or ligament injuries, especially in ACL injuries, and that rare TT may played as a protective role. PMID: 28206959
    26. Significance was detected for GG homozygous carriers (P=0.043); this genotype might be a risk factor for this type of low-density lesion (odds ratio 1.643, 95% confidence interval 1.016-2.658). PMID: 27371342
    27. Breast cancer cells alter the dynamics of stromal fibronectin-collagen interactions. PMID: 27503584
    28. COL1a1 crystal structure of fibronectin type III domain shows an immunoglobulin-like fold containing a beta-sandwich structure, which is formed by a three-stranded beta-sheet. PMID: 29199991
    29. Alterations in the extracellular matrix microenvironment, particularly type I collagen, likely contributes to bladder cancer progression. PMID: 27655672
    30. Strong correlations between the expression of type I, II, IV collagen and osteopontin and the clinical stage of tympanosclerosis indicate the involvement of these proteins in excessive fibrosis and pathological remodeling of the tympanic membrane. PMID: 29068597
    31. The results support the association of COL1A1 gene polymorphisms with fracture and with low BMD at the hip in Mexican population PMID: 26423565
    32. urinary N-telopeptide measured in early postmenopause is most strongly associated with rates of bone loss across the menopause transition. PMID: 27322414
    33. Abnormal regulation of COL1 and COL3 may contribute to the early predisposition to POP in premenopausal women. PMID: 27636223
    34. Genetic variation in COL1A1 and COL1A2 associated with osteogenesis imperfect in Vietnamese patients. PMID: 27519266
    35. 2 patients with osteogenesis imperfecta (father and daughter) had a previously undescribed c.3607C>T (p.Gln1203*) change in the COL1A1 gene. PMID: 27178384
    36. In the patient diagnosed with PCG and retinal detachment, analysis of WES data identified compound heterozygous variants in COL1A1 (p.Met264Leu; p.Ala1083Thr). PMID: 27484908
    37. These data, together with those available in literature, suggest that vascular events are not a diagnostic handle to differentiate patients with the p.(Arg312Cys) COL1A1 mutation from those with COL5A1 and COL5A2 defects, and highlight that during the diagnostic process the presence of at least the p.(Arg312Cys) substitution in COL1A1 should be investigated in cEDS patients without type V collagen mutations. PMID: 28102596
    38. we report an infant with severe OI born following a twin pregnancy in whom the bone disease is caused by a heterozygous pathogenic mutation, c.4160C >T, p.(Ala1387Val) located in the C-propeptide region of COL1A1. Our case adds to the growing evidence of the literature on mutations in the C-propeptide region being associated with a severe OI phenotype. PMID: 27549894
    39. We conducted a retrospective analysis of data from clinical, laboratory, and radiographic information from children evaluated for child abuse in which molecular testing for COL1A1 and COL1A2 genes was conducted. A total of 43 patients underwent molecular testing for Osteogenesis imperfecta (OI) PMID: 27090748
    40. our data revealed that COL1A1, UCP2, and PRPF40A are novel players implicated in the complex network of hypoxia response in non-small cell lung cancer PMID: 28258342
    41. In the individuals with a COL1A1 mutation, 70% (7/10) of those with a glycine substitution located C-terminal of p.Gly305 exhibited DGI in both dentitions while no individual (0/7) with a mutation N-terminal of this point exhibited DGI in either dentition PMID: 28498836
    42. Large COPII vesicles are transport carriers of intracellular carriers of procollagen I. PMID: 28428367
    43. we established a new regulatory model of COL1A1 regulation by HIF-1, and bring out its relationship with Sp3 transcription factor. In a fundamental level, these findings give insights in the mechanisms controlling COL1A1 gene expression. PMID: 27521280
    44. UBQLN4, APP, CTNNB1, SHBG, and COL1A1 might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition PMID: 28796060
    45. The levels of the bone formation marker PICP in premenopausal rheumatoid arthritis women were significantly higher than in healthy premenopausal controls. There was a highly significant difference between postmenopausal patients with RA and control pre- and postmenopausal women. Furthermore, postmenopausal RA women had significantly higher plasma PICP concentrations than premenopausal women with RA PMID: 27775453
    46. Depletion of FKBP65 and inhibition of FKBP65 activity reduced the dimeric (active) form of LH2 but did not affect the binding of monomeric (inactive) LH2 to procollagen Ialpha1. PMID: 27298363
    47. This is the first study to quantitatively relate pressure-induced microstructural changes in resistance arteries to the mechanics of their wall. Principal findings using a pig model system were confirmed in human arteries. The combined methods provide a strong tool for future hypothesis-driven studies of microvascular pathologies. PMID: 28432057
    48. COL11A1 as a highly specific biomarker of activated cancer-associated fibroblasts in epithelial cancers. PMID: 27609069
    49. miR-29b can reduce collagen biosynthesis during skin wound healing likely via post-transcriptional inhibition of HSP47 expression. PMID: 27477081
    50. The study shows that circCOL3A1-859267 RNA regulate type I collagen expression in photoaged human dermal fibroblasts, suggesting it may be a novel target for interfering with photoaging. PMID: 28286269

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  • 相关疾病：
    Caffey disease (CAFFD); Ehlers-Danlos syndrome, classic type (EDS); Ehlers-Danlos syndrome 7A (EDS7A); Osteogenesis imperfecta 1 (OI1); Osteogenesis imperfecta 2 (OI2); Osteogenesis imperfecta 3 (OI3); Osteogenesis imperfecta 4 (OI4); Osteoporosis (OSTEOP)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibrillar collagen family
  • 组织特异性：
    Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
  • 数据库链接：

    HGNC: 2197

    OMIM: 114000

    KEGG: hsa:1277

    STRING: 9606.ENSP00000225964

    UniGene: Hs.172928

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