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  4. Recombinant Human Diacylglycerol kinase delta (DGKD), partial

Recombinant Human Diacylglycerol kinase delta (DGKD), partial

  • 中文名称：
    人DGKD重组蛋白
  • 货号：
    CSB-YP624117HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DGKD重组蛋白
  • 货号：
    CSB-EP624117HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DGKD重组蛋白
  • 货号：
    CSB-EP624117HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DGKD重组蛋白
  • 货号：
    CSB-BP624117HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DGKD重组蛋白
  • 货号：
    CSB-MP624117HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DGKD
  • Uniprot No.：
    Q16760
  • 别名：
    DGKD; KIAA0145Diacylglycerol kinase delta; DAG kinase delta; EC 2.7.1.107; 130 kDa diacylglycerol kinase; Diglyceride kinase delta; DGK-delta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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DGKD antibodies

靶点详情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-depen...显示更多
  • 基因功能参考文献：
    1. purification and characterization of DGKepsilon's enzymatic and conformational properties PMID: 28199087
    2. Diacylglycerol signaling limits Akt activation through diacylglycerol kinase delta and PHLPP2. PMID: 23184957
    3. This study demonistrated that the lack of association of DGKD SNPs with PD in the Han Chinese population. PMID: 22406787
    4. Zinc site mutations impair DGKdelta localization to cytoplasmic puncta and enhance localization the plasma membrane. PMID: 20857926
    5. Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase Calpha modulate the levels of ubiquitinated epidermal growth factor receptors through Akt and ubiquitin-specific protease 8. PMID: 20064931
    6. Alternative splicing of the gene generates two isoforms differing in their expression patterns and in regulatory functions PMID: 12200442
    7. Phosphorylation is involved in the control of subcellular localization of DGKdelta1. PMID: 15228384
    8. Disruption of diacylglycerol kinase delta (DGKD) is associated with seizures in humans and mice. PMID: 17357084
    9. Study identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from type 2 diabetic patients. PMID: 18267070
    10. Polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location. PMID: 18334213

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  • 亚细胞定位：
    Membrane, clathrin-coated pit. Cytoplasm.; [Isoform 1]: Cell membrane; Peripheral membrane protein. Cytoplasm.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 组织特异性：
    [Isoform 2]: Widely expressed.; [Isoform 1]: Only detected in ovary, and to a lesser extent in spleen.
  • 数据库链接：

    HGNC: 2851

    OMIM: 601826

    KEGG: hsa:8527

    STRING: 9606.ENSP00000264057

    UniGene: Hs.471675

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