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  4. Recombinant Human Glutamate [NMDA] receptor subunit 3A (GRIN3A), partial

Recombinant Human Glutamate [NMDA] receptor subunit 3A (GRIN3A), partial

  • 中文名称：
    人GRIN3A重组蛋白
  • 货号：
    CSB-YP840568HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GRIN3A重组蛋白
  • 货号：
    CSB-EP840568HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GRIN3A重组蛋白
  • 货号：
    CSB-EP840568HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GRIN3A重组蛋白
  • 货号：
    CSB-BP840568HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GRIN3A重组蛋白
  • 货号：
    CSB-MP840568HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GRIN3A
  • Uniprot No.：
    Q8TCU5
  • 别名：
    GRIN3A; KIAA1973; Glutamate receptor ionotropic; NMDA 3A; GluN3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; NR3A; NMDAR-L
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role ...显示更多
  • 基因功能参考文献：
    1. Results suggest that GRIN3A rs17189632 and GRIN3B rs2240158 may contribute to the susceptibility of heroin addiction. PMID: 27542340
    2. discuss current evidence for emerging roles for GluN3NMDARs in the physiology and pathology of the CNS. PMID: 27558536
    3. Increased expression levels of MAPT and GRIN3A may lead to the abnormal pathologic condition of nerve tissue in macrodactyly and, to a certain extent, may have potential applications in nerve regeneration. PMID: 27840953
    4. The rare variants in GRIN3A were significantly associated with smoking status. PMID: 25450229
    5. Single nucleotide polymorphism in GRIN3A is associated with osteonecrosis in children with acute lymphoblastic leukemia. PMID: 26265699
    6. the genetic variations of NR3A subunit of NMDA receptor may be a predisposing factor to delirium among the Polish population of cardiac surgery patients PMID: 25041634
    7. Our results suggest that a polymorphism of the GRIN3A gene may play a role in KD pathogenesis. PMID: 24278430
    8. Isolated GluN1/GluN3A receptors integrated into lipid bilayers responded to addition of either glycine or d-serine, but not glutamate, with a approximately 1 nm reduction in height of the extracellular domain PMID: 25017909
    9. It modulates episodic memory. PMID: 24332987
    10. This review highlights GluN3A properties and addresses its role in neurophysiology and associated pathologies--{REVIEW} PMID: 24386575
    11. the GRIN3A R480G variant showed the strongest association with schizophrenia. PMID: 23237318
    12. These findings reveal an early pathogenic role of GluN3A dysregulation in Huntington's disease. PMID: 23852340
    13. reductions of toxic calpain activation might be linked to inhibition by GluN3A of pathological extrasynaptic NMDAR activity. PMID: 22801082
    14. Vasoactive intestinal polypeptipe and GRIN3A SNPs may be associated with cerebral palsy at age 2 in children born preterm. PMID: 22914463
    15. In a human embryonic brain cDNA library mTOR-activating GTPase Rheb is screened as an interacting protein of the NMDAR subunit NR3A. PMID: 21135540
    16. NR3a, by maintaining low intracellular calcium levels, protects the function of the principal cells to reabsorb water and thereby increase medullary osmolality PMID: 21429969
    17. Data show that that all seven currently known NMDAR subunits (NR1, NR2A, NR2B, NR2C, NR2D, NR3A and NR3B) are expressed in astrocytes, but at different levels. PMID: 21152063
    18. significant lower protein and mRNA levels of the N-methyl-D-aspartate receptors, NR-1 and hr-3a in frontal corte in bipolar disorder. PMID: 19488045
    19. Results indicate that GRIN3A is significantly associated with nicotine dependence. PMID: 20084518
    20. These observations suggest that the genetic variation of the NR3A subunit of the NMDA receptor may be a risk factor for Alzheimer's dis pathogenesis PMID: 20016182
    21. NR3A is highly expressed in the developing human neocortex PMID: 14684485
    22. NR3 NMDA receptors induce plasticity in NR1 with respect to subunit assembly and ligand binding/channel coupling that is unique among ligand-gated ion channel subunits. PMID: 17047094
    23. Individuals carrying Val/Val genotype showed significantly reduced frontal P300 amplitudes compared with Met/Met subjects. PMID: 17214563
    24. This review summarizes recent research regarding the functional roles of the N-methyl-D-aspartate (NMDA) receptor subunit NR3A in dendrite spine formation, plasticity and synaptogenesis, and sensory processing in the spinal cord [review]. PMID: 17617428
    25. NR3A was found in the cerebral cortex, subcortical forebrain, midbrain and hindbrain. Very low levels of NR3A could be detected in homogenized adult human spinal cord, limited to ventral motoneurons. PMID: 17997397
    26. a case-control association study of common nucleotide variants of the GRIN3A gene with susceptibility to schizophrenia; findings did not show any difference in allele and genotype frequency of each polymorphism between patients and controls PMID: 18075478
    27. NR3A levels are low during gestation, surge soon after birth, and decline progressively through adolescence and into adulthood PMID: 18296432
    28. NMDA receptor protein subunit NR3A overexpressed in transgenic mice protects them from neuronal damage due to cerebral ischemia. PMID: 19386922
    29. This study indicated that rare mutations in the GRIN3A gene may contribute to the pathogenesis of schizophrenia in certain patients. PMID: 19665356

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, NR3A/GRIN3A subfamily
  • 数据库链接：

    HGNC: 16767

    OMIM: 606650

    KEGG: hsa:116443

    STRING: 9606.ENSP00000355155

    UniGene: Hs.654783

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