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  4. Recombinant Human Myotubularin-related protein 3 (MTMR3), partial

Recombinant Human Myotubularin-related protein 3 (MTMR3), partial

  • 中文名称：
    人MTMR3重组蛋白
  • 货号：
    CSB-YP622675HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MTMR3重组蛋白
  • 货号：
    CSB-EP622675HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MTMR3重组蛋白
  • 货号：
    CSB-EP622675HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MTMR3重组蛋白
  • 货号：
    CSB-BP622675HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MTMR3重组蛋白
  • 货号：
    CSB-MP622675HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MTMR3
  • Uniprot No.：
    Q13615
  • 别名：
    FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; MTMR3; MTMR3_HUMAN; Myotubularin-related protein 3; Zinc finger FYVE domain-containing protein 10
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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MTMR3 antibodies

靶点详情

  • 功能：
    Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues.
  • 基因功能参考文献：
    1. Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus. PMID: 26787466
    2. the rs713875 IBD risk polymorphism increases MTMR3 expression, which modulates pattern recognition receptor (PRR)-induced outcomes, including increased induced caspase-1 activation PMID: 26240347
    3. myotubularin-related protein 3 and myotubularin-related protein 4 may act as a bridge between CEP55 and polo-like kinase 1, ensuring proper CEP55 phosphorylation and regulating CEP55 recruitment to the midbody. PMID: 25659891
    4. cloning, expression, purification and crystallization of human myotubularin-related protein 3 encompassing the PH-GRAM and the phosphatase catalytic domain are reported PMID: 25195900
    5. These results indicate that MTMR3 may play an important role in the progression of CRC and suggest that siRNA mediated silencing of MTMR3 could be an effective tool in CRC treatment. PMID: 25215329
    6. Our results suggest that the MTMR3 gene is shared between IgA nephropathy and lupus nephritis in the northern Chinese population, further highlighting the role of autophagy in systemic lupus erythematosus. PMID: 24943867
    7. Data suggest MTMR3, PIKFYVE (phosphoinositide kinase FYVE), and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein); this process regulates migration/invasion of carcinoma/sarcoma. PMID: 24840251
    8. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. PMID: 23154468
    9. MTMR3 belongs to the myotubularin family of phosphoinositides phosphatases PMID: 9736772
    10. MTMR3 shares similar phosphatase activity and substrate specificity with its homologous proteins MTM1 and MTMR3 PMID: 11846405
    11. A phylogenetic study revealing co-evolution of myotubularins with PI 3-kinase class III complex PMID: 18774718
    12. Autophagosome formation was triggered by the overexpression of a dominant-negative inactive mutant of Myotubularin-related phosphatase 3 (MTMR3). PMID: 20059746
    13. analysis of MTMR3 phosphoinositide binding domain properties PMID: 15840652

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 数据库链接：

    HGNC: 7451

    OMIM: 603558

    KEGG: hsa:8897

    STRING: 9606.ENSP00000384651

    UniGene: Hs.474536

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