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  4. Recombinant Human Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B), partial

Recombinant Human Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B), partial

  • 中文名称：
    人PIK3C2B重组蛋白
  • 货号：
    CSB-YP017995HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PIK3C2B重组蛋白
  • 货号：
    CSB-EP017995HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PIK3C2B重组蛋白
  • 货号：
    CSB-EP017995HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PIK3C2B重组蛋白
  • 货号：
    CSB-BP017995HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PIK3C2B重组蛋白
  • 货号：
    CSB-MP017995HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PIK3C2B
  • Uniprot No.：
    O00750
  • 别名：
    PIK3C2B; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; PI3K-C2-beta; PtdIns-3-kinase C2 subunit beta; EC 2.7.1.154; C2-PI3K; Phosphoinositide 3-kinase-C2-beta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
  • 基因功能参考文献：
    1. this study suggests that PIK3C2B might only have a minor role in SQCC oncogenesis PMID: 29088297
    2. PI3KC2B-silencing inhibits early stages of neuroblastoa tumorigenic growth. PMID: 25622909
    3. Data suggest a novel role for nucleotide-free Ras in cell signaling in which PI3KC2beta stabilizes nucleotide-free Ras and that interaction of Ras and PI3KC2beta mutually inhibit one another. PMID: 23028960
    4. The results of this study showed that strong association between PIK3C2B gene alternation and high-grade oligodendroglial tumors. PMID: 22825724
    5. These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 as a previously undescribed negative regulator of CD4 T cells. PMID: 22128329
    6. Overexpression of PIK3C2B is associated with esophageal squamous cell carcinoma. PMID: 21986133
    7. different human small cell lung carcinoma cell lines overexpress distinct subsets of PI3Ks, resulting in differences in signalling cascades activated by stem cell factor; insights into specificity and functional significance of PI3K signalling in cancer PMID: 12356726
    8. activity of nuclear phosphoinositide 3-kinase C2beta investigated in HL-60 cells induced to differentiate along granulocytic or monocytic lineages PMID: 12372612
    9. plays a regulatory role in cell motility PMID: 16113997
    10. identified the 185-kDa protein altered by nitrotyrosylation in platelets from patients with systemic sclerosis as phosphoinositide kinase C2beta (PI 3-K); the activity of PI 3-K increases in nitrotyrosylated platelet lystaes from patients with SSc PMID: 16271833
    11. Class II phosphoinositide 3-kinase C2beta isnot essential for epidermal differentiation PMID: 16314532
    12. These findings suggest that PI3KC2beta regulates the migration and survival of human tumor cells by distinct molecular mechanisms. PMID: 16775008
    13. Epidermal growth factor stimulates the appearance of PI3K-C2beta in nuclei. PMID: 19496756
    14. Data show that the class II phosphatidylinositol 3 kinase C2beta (PI3K-C2beta) is activated by the T-cell receptor (TCR) and functions upstream of NDPK-B to activate KCa3.1 channel activity. PMID: 19587117

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  • 亚细胞定位：
    Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
  • 蛋白家族：
    PI3/PI4-kinase family
  • 组织特异性：
    Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.
  • 数据库链接：

    HGNC: 8972

    OMIM: 602838

    KEGG: hsa:5287

    STRING: 9606.ENSP00000356155

    UniGene: Hs.497487

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