Recombinant Human Serine/threonine-protein kinase ULK1 (ULK1), partial

1. Our results suggest that ULK1 is upregulated in Clear Cell Renal Carcinoma tumors and may be a potential therapeutic target. PMID: 30078736
2. the nucleation of autophagosomes occurs in endoplasmic reticulum tubulovesicular regions, where the ULK1 complex coalesces with ER and the ATG9 compartment PMID: 27510922
3. rs9652059 variation (C-->T) could increase AS susceptibility and haplotypes of rs9652059(C)-rs4964879(G), rs9652059(C)-rs11616018(T) and rs9652059(T)-rs11616018(T) may be associatd with AS in a Chinese Han population. PMID: 28667165
4. Simultaneous high expression of ULK1 (and LC3B) had a poorer overall survival rate in hepatocellular cancer patients. PMID: 29091866
5. Authors conclude that miR-93 is involved in hypoxia-induced autophagy by regulating ULK1. Results provide a new angle to understand the complicated regulation of the key autophagy kinase ULK1 during different stress conditions. PMID: 29109831
6. this study found that upregulation of MACC1 in ESCC was associated with lymph node metastasis of patients, and MACC1 regulated ESCC cell proliferation, apoptosis, migration and invasion mainly through AMPK-ULK1 induced autophagy PMID: 28791376
7. ULK1 phosphorylation at 3 different sites on the same ULK1 target region for NEDD4L is preparatory for its ubiquitylation and subsequent degradation. PMID: 28820317
8. Activation of autophagy can attenuate accumulation of LPL, thereby limiting fatty acid excess, and prevent cardiac dysfunction in obese hearts via ULK1. PMID: 28430962
9. Overexpression of unc-51 like autophagy activating kinase causes elevated autophagy and aggregation of the ER exit sites(ERES), a region of the ER dedicated for the budding of COPII vesicles. Transport of cargo proteins is therefore inhibited and is retained at the ERES. PMID: 28486929
10. silencing of HOTAIR decreased drug resistance of Non-Small Cell Lung Cancer cells to Crizotinib through inhibition of autophagy via suppressing phosphorylation of ULK1. PMID: 29470986
11. CLDN1 activates autophagy through up-regulation of ULK1 phosphorylation and promotes drug resistance of non-small cell lung cancer cells to cisplatin. PMID: 28614291
12. These findings revealed that prosurvival autophagy was one of the mechanisms involved in the resistance acute myeloid leukemia (AML) leukemia stem cells to JQ1. Targeting the AMPK/ULK1 pathway or inhibition of autophagy could be an effective therapeutic strategy for combating resistance to BET inhibitors in AML and other types of cancer PMID: 27864418
13. we demonstrate that Ulk1 over-expression in human gastric cancer is pro-survival. Its over-expression is associated with patients' T classification and cancer relapse. PMID: 28410240
14. our results show that inhibition of Ulk1 suppresses Non-small cell lung cancer (NSCLC)cell growth and sensitizes NSCLC cells to cisplatin by modulating both autophagy and apoptosis pathways, and that Ulk1 might be a promising target for NSCLC treatment. PMID: 28498429
15. review the diverse roles of ULK1, with special focus on its importance to type I IFN signaling, and highlight important future study questions. PMID: 27068414
16. ULK1 played a crucial role in ALDH2-offered protective effect against high glucose exposure-induced cardiomyocyte injury through regulation of autophagy PMID: 29128638
17. Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through reactive oxygen species-AMPK-ULK1 signaling dysregulation independently of HIF-1A. PMID: 27687210
18. phosphorylation of mATG9 at Tyr8 by Src and at Ser14 by ULK1 functionally cooperate to promote interactions between mATG9 and the AP1/2 complex. PMID: 27934868
19. we found that ATG14 interacted with Ulk1 and LC3, and knock down of Ulk1 prevented the lipidation of LC3 and autophagy in HeLa-ATG14 cells. We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. PMID: 28069524
20. Data show that ULK1, a protein kinase activated at the autophagosome formation site, phosphorylates human ATG4B on serine 316. PMID: 28821708
21. While focusing on the role of SMCR8 during autophagy initiation, we found that kinase activity and gene expression of ULK1 are increased upon SMCR8 depletion. The latter phenotype involved association of SMCR8 with the ULK1 gene locus. PMID: 28195531
22. despite the significant upregulation of mRNA of the essential autophagy initiation gene ULK1, its protein level is rapidly reduced under starvation. PMID: 27629431
23. Our findings demonstrate for the first time that miR-26a/b can promote apoptosis and sensitize Hepatocellular carcinoma (HCC) to chemotherapy via suppressing the expression of autophagy initiator ULK1, and provide the reduction of miR-26a/b in HCC as a novel mechanism of tumor chemoresistance. PMID: 28079894
24. Downregulation of ULK1 inhibited the overexpression effects of miR-372, and upregulation of ULK1 reversed the effects of overexpressed miR-372 in human pancreatic adenocarcinoma cells. PMID: 28677209
25. These findings reveal that Endoplasmic reticulum stress engages the GSK3beta-TIP60-ULK1 pathway to increase autophagy. PMID: 28032867
26. ULK1/2 function as a bifurcate-signaling node that sustains glucose metabolic fluxes besides initiation of autophagy in response to nutritional deprivation. PMID: 27153534
27. these results demonstrate the effective anti-autophagic of NRAGE in non-small-cell lung cancer cells through AMPK/Ulk1/Atg13 autophagy signaling pathways. Therefore, NRAGE could be used as a potential therapeutic target for lung cancer. PMID: 28639909
28. results from western blotting assays and immunoprecipitation assays displayed that sirtuin 6 specifically interacted with ULK1 and positively regulated its activity by inhibiting its upstream factor mammalian target of rapamycin activity. PMID: 28653878
29. As a Rab1a effector, C9orf72 controls initiation of autophagy by regulating the Rab1a-dependent trafficking of the ULK1 autophagy initiation complex to the phagophore. PMID: 27334615
30. Ulk1 promoted the degradation of Hsp90-Cdc37 client kinases, resulting in increased cellular sensitivity to Hsp90 inhibitors. Thus, our study provides evidence for an anti-proliferative role of Ulk1 in response to Hsp90 inhibition in cancer cells PMID: 28073914
31. Here, the authors demonstrate that S100A10 is required for ULK1 localization to autophagosome formation sites. Silencing of S100A10 reduces IFN-gamma-induced autophagosome formation. PMID: 27871932
32. A strong association of rs12297124, a noncoding ULK1 SNP, with LTBI and a role for ULK1 regulation of TNF secretion. PMID: 27485354
33. High expression of ULK1 concomitant with high expression of LRPPRC may serve as useful markers for shorter biochemical progression (BCP)-free survival and overall survival in patients with metastatic prostate cancer (PCa) after androgen deprivation therapy (ADT). PMID: 27679555
34. These results thus place NEDD4L and ULK1 in a key position to control oscillatory activation of autophagy during prolonged stress to keep the levels of this process under a safe and physiological threshold. PMID: 27932573
35. These results demonstrate a novel mechanism by which STAT1 negatively regulates ULK1 expression and autophagy. PMID: 28011640
36. These results show that the SiMoA technology can detect quantitatively low levels of endogenous biomarkers with the ability to detect the loss of pSer(318)-Atg13 upon ULK1 inhibition. PMID: 27387056
37. The newly developed ULK1 PCR assay was applied to genotype samples from 100 healthy individuals of North Indian origin. Genotype frequencies were 9, 34 and 57 % for GG, GT and TT, respectively. Allele frequencies were 0.26 and 0.74 for G and T, respectively. The allele frequencies were in Hardy-Weinberg's equilibrium (p = 0.2443). PMID: 27783190
38. These results define a key molecular event for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1. PMID: 27046250
39. Knockdown of either ULK1 or DLP1 expression with shRNAs suppresses LRRK2 G2019S expression-induced mitochondrial clearance, suggesting that LRRK2 G2019S expression induces mitochondrial fission through DLP1 followed by mitophagy via an ULK1 dependent pathway. PMID: 27023913
40. Of several factors examined, bone metastasis, liver metastasis, and ULK1 expression were shown to have significant effects on the response to mTOR inhibitors. PMID: 26299883
41. ULK1 could inhibit p70S6K in starvation-induced autophagy, and further identified that miR-4487 and miR-595 were novel ULK1 target miRNAs PMID: 26183158
42. Structure of the human Atg13-Atg101 HORMA heterodimer in the ULK1 complex that controls autophagy has been described. PMID: 26299944
43. MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy PMID: 26018823
44. the inhibition of deubiquitinases by the compound WP1130 leads to increased ULK1 ubiquitination, the transfer of ULK1 to aggresomes, and the inhibition of ULK1 activity. PMID: 26207339
45. ROS-AMPK-ULK1 mechanism that couples T3-induced mitochondrial turnover with activity, wherein mitophagy is necessary not only for removing damaged mitochondria but also for sustaining efficient OXPHOS PMID: 26103054
46. Study identifies a key role of Cul3-KLHL20 in autophagy termination by controlling autophagy-dependent turnover of ULK1 and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism. PMID: 26687681
47. Findings highlight a cytoprotective role of p32 under starvation conditions by regulating ULK1 stability, and uncover a crucial role of the p32-ULK1-autophagy axis in coordinating stress response, cell survival and mitochondrial homeostasis. PMID: 25909887
48. Concurrent mTORC1 inactivation and PP2A-B55alpha stimulation fuel ULK1-dependent autophagy. PMID: 26310906
49. ULK1-mediated autophagy has a role in retinoic acid-induced IgG production in TLR9-activated human primary B cells PMID: 25749095
50. a novel signaling pathway identified whereby starvation-induced activation of ULK leads to phosphorylation of endogenous DENND3, with subsequent activation of Rab12 and initiation of membrane trafficking events required for autophagy PMID: 25925668

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HGNC: 12558

OMIM: 603168

KEGG: hsa:8408

STRING: 9606.ENSP00000324560

UniGene: Hs.47061