Recombinant Human Sodium/hydrogen exchanger 1 (SLC9A1), partial

1. NHE1 regulates intracellular pH in human ovarian tumour cells. NHE1 activity is a pro-proliferative factor in human ovarian tumour cells. PMID: 27773735
2. a novel homozygous SLC9A1 truncating mutation, c.862del (p.Ile288Serfs*9), in two affected siblings. The patients showed cerebellar ataxia but neither of them showed sensorineural hearing loss nor a neuromuscular phenotype. PMID: 30018422
3. This study provides the first line of evidence for a causative role of astrocytic NHE1 protein in reactive astrogliosis and ischemic neurovascular damage PMID: 28925083
4. The disordered distal tail of the Na+/H+ exchanger 1 (NHE1) is six-times phosphorylated (S693, S723, S726, S771, T779, S785) by the mitogen activated protein kinase 2 (MAPK1, ERK2). Using NMR spectroscopy, this study found that two out of those six phosphorylation sites had a stabilizing effect on transient helices. PMID: 28554535
5. NHE1 and Akt are downregulated in human umbilical vein endothelial cells by tumor microenvironment conditions, more potently than by hypoxia alone. This inhibits endothelial cell migration and growth in a manner likely modulated by the cancer cell secretome. PMID: 28806945
6. Study shows for the first time that CD95L activates NHE1, which thereby enhances cell migration. Using a combination of inhibitors and site-directed mutagenesis, results subsequently demonstrate that this mechanism occurs through a modification of NHE1 cooperative response to intracellular protons and that it involves both the Akt and RhoA-dependent pathways. PMID: 27302366
7. The suppression of NHE1 in esophageal squamous cell carcinoma (ESCC) may enhance malignant potential by mediating PI3K-AKT signaling and epithelial-mesenchymal transition via Notch signaling, and may be related to a poor prognosis in patients with ESCC. PMID: 27902974
8. Genetic disruption of the intracellular pH-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 reduces the proliferation of colon cancer cells. PMID: 28055960
9. NHE1 mutation is associated with metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer. PMID: 27049728
10. The expression pattern of sNHE suggested that this protein may be involved in the regulation of sperm motility, and aberration of its expression in sperm may contribute to the pathogenesis of asthenozoospermia. PMID: 28432487
11. Data show for the first time that PRLR activation stimulates breast cancer cell invasiveness via the activation of NHE1. Data propose that PRL-induced NHE1 activation and the resulting NHE1-dependent invasiveness may contribute to the metastatic behavior of human breast cancer cells. PMID: 27176613
12. These data provides the first insight into the signalling molecules that form the NHE1 interactome in triple-negative breast cancer cells. PMID: 27751915
13. NHE1 is a plasma membrane transporter that uses the energy of the chemical gradient created by the Na+/K+ ATPase to couple the transport of one extracellular sodium for one intracellular proton. NHE1 functional domains, functional features, protein interactions, role in cell migration, and inhibitors are reviewed. A model of its role in pH control in tumor cells is described. Review. PMID: 26944480
14. The transcription factor Zeb1 binds to the Na+/H+ exchanger 1 promoter, suggesting that Zeb1 directly controls Na+/H+ transcription. PMID: 27434882
15. NHE1 function plays an important role in glioma-microglia interactions, enhancing glioma proliferation and invasion by stimulating microglial release of soluble factors. PMID: 27287871
16. results demonstrate that early stop codon polymorphisms have significant and deleterious effects on the activity of the SLC9A1 protein product. The 735-NHE1 mutant, without the last 80 amino acids, had more minor defects PMID: 27636896
17. the accumulation of reactive oxygen species (ROS) in cells expressing JAK2V617F compromises the NHE-1/Bcl-xL deamidation pathway by repressing NHE-1 upregulation in response to DNA damage. hematopoietic stem cells (HSCs), FOXO3A is largely localized within the nuclei despite the presence of JAK2V617F mutation, suggesting that JAK2-FOXO signaling has a different effect on progenitors compared with stem cells. PMID: 26234675
18. Findings suggest that Na(+)/H(+) exchanger1 (NHE1) could be a target for anti-invasion/metastasis therapy. PMID: 28268168
19. These data identify a molecular mechanism for pH-sensitive PI(4,5)P2 binding regulating NHE1 activity and suggest that the evolutionarily conserved cluster of four histidines in the proximal cytoplasmic domain of NHE1 may constitute a proton modifier site. PMID: 27650500
20. Results indicate that Nav 1.7 promotes GC progression through MACC1-mediated upregulation of NHE1. PMID: 27529686
21. High NHE1 expression is associated with gastric cancer. PMID: 28098891
22. In human ovarian cancer cells the inducible nitric oxide synthase (iNOS) is overexpressed leading to increased formation of nitric oxide (NO). The NO promotes a glycolytic phenotype (Warburg effect) leading to H+ generation, which are removed via the sodium, proton (H+) exchanger isoform 1 (NHE1) reducing the intracellular content of this acid equivalent. PMID: 26821117
23. Data show that both mineralcorticoid receptor (MR) and G-protein estrogen receptor (GPER) contribute to the proliferation and migration of breast and endothelial cancer cells by sodium-hydrogen exchanger 1 protein (NHE-1) upon aldosterone exposure. PMID: 26646587
24. The NHE-1 is a ubiquitously expressed cell membrane protein which regulates intracellular pH (pH(i)) and extracellular pH (pH(e)) homeostasis and cell volume. PMID: 25620102
25. Functional studies of N266H mutation in SLC9A1 gene showed a minor effect on the level of expression and no effect on targeting of the protein, however there was a complete absence of SLC9A1 activity. PMID: 25760855
26. Data suggest that Na/H exchanger isoform one (NHE1) is critical in triple-negative breast cancer metastasis. PMID: 25514463
27. Importantly, the specific NHE1 inhibitor cariporide reduced both three-dimensional growth and invasion independently of PDAC subtype and synergistically sensitized these behaviors to low doses of erlotinib. PMID: 25748234
28. Concurrent speed endurance and resistance training increases skeletal muscle NHE1 activity. PMID: 25190744
29. Mutation of SLC9A1 is associated with ataxia-deafness Lichtenstein-Knorr syndrome. PMID: 25205112
30. NHE1 mediates HeLa cell metastasis via regulating the expression and localization of MT1-MMP and provides a theoretical basis for the development of novel therapeutic strategies targeting cervical cancer. PMID: 21997166
31. This review focuses on the role of NHE1 and OPN in cardiac remodeling and emphasizes the signaling pathways implicating OPN in the NHE1-induced hypertrophic response. PMID: 25677682
32. the results support the anti-apoptotic role of HO-1 induced by NHE1 in the K562R cell line and IM-insensitive CML patients PMID: 25802333
33. The results demonstrate that the Ser771Pro human genetic mutation has significant and detrimental physiological effects on the activity of the NHE1 protein, SLC9A1. PMID: 25162926
34. These results suggest a novel tumor suppressor function of merlin in melanoma cells: the inhibition of the proto-oncogenic NHE1 activity, possibly including its downstream signaling pathways. PMID: 25275700
35. The findings are consistent with a role for R425 in both neutralizing a helix dipole and maintaining NHE1 structure and function. PMID: 25350536
36. CIAPIN1 over-expression decreases NHE1 expression and ERK1/2 phosphorylation. PMID: 25724898
37. We demonstrate, for the first time, that 3 different pHi regulators responsible for acid extruding, i.e. NHE and NBC, and MCT, are functionally co-existed in cultured radial artery smooth muscle cells. PMID: 25241983
38. CIAPIN1 targeted NHE1 to mediate differentiation of K562 cells via ERK1/2 pathway. PMID: 25043809
39. NHE1 upregulation is an important cytoprotective mechanism in human glioma cells. PMID: 24717311
40. The regulation of NHE-1 activity mediated by PKC-beta activation involves NHE-1 phosphorylation, which implies that the phosphorylation of NHE-1 directly affects glutamate-induced neuronal cell death. PMID: 24378530
41. Protease activity suppression increases relative invadopodial NHE1 expression, while NHE1 inhibition increases acid-induced protease secretion. PMID: 24337203
42. Talin has a role in regulating moesin-NHE-1 recruitment to invadopodia in breast cancer PMID: 24891603
43. NHE1 transmembrane (TM) region VI from V240 to V245 is closely associated with TM region VII and, in agreement with nuclear magnetic resonance (NMR) structure of VI-VII segments, V242 and F260 are in close association. PMID: 24840010
44. probucol via inhibition of NHE1 attenuates atherosclerosis lesion growth and promotes plaque stability PMID: 24594116
45. Disruption of the DNM2-dependent retrograde trafficking of NHE1 contributes to cardiomyocyte apoptosis. PMID: 23837875
46. CD44 regulates the metastasis of breast cancer cells through regulating NHE1 expression, which could be used as a novel strategy for breast cancer therapy. PMID: 24434427
47. modulation of NHE1 activity by various activators and inhibitors occurs through the direct binding of these molecules to the LID, which alters the association of the LID with the plasma membrane. PMID: 24136992
48. Phosphorylation of S770/S771 changes the conformation of the NHE1 C-terminal regulatory region in a pH-dependent manner. PMID: 23602949
49. Functional insights inferred from NHE1 structure models and analysis. [Review] PMID: 23220151
50. The molecular mechanisms underlying NHE1 regulation. [Review] PMID: 23429007

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HGNC: 11071

OMIM: 107310

KEGG: hsa:6548

STRING: 9606.ENSP00000263980

UniGene: Hs.469116