Recombinant Human Transient receptor potential cation channel subfamily V member 4 (TRPV4), partial

1. TRPV4 mediates Ca(2+) influx and nuclear accumulation of DDX3X in cells exposed to the Zika virus. Targeting of TRPV4 reduces infectivity of dengue, hepatitis C and Zika viruses. Our results highlight the role of TRPV4 in the regulation of DDX3X-dependent control of RNA metabolism and viral infectivity. PMID: 29899501
2. Results suggest that transient receptor potential vanilloid 4 (TRPV4) accelerates glioma migration and invasion through the AKT/Rac1 signaling, and TRPV4 might be considered as a potential target for glioma therapy. PMID: 29928875
3. study for the first time demonstrated an abnormal TRPV4-related mechanosensitive Ca(2+) signaling in Dilated cardiomyopathy induced-pluripotent stem cells-derived cardiomyocytes. PMID: 28754452
4. There is expression of TRPV4 channels on the nerve fibers of human dental pulp. Findings suggest upregulation of TRPV4 expression under inflammatory conditions in the pulp. The upregulation of TRPV4 channels may be associated with the exaggerated response of dental pulp to innocuous mechanical, thermal and osmotic stimuli under inflammatory conditions. PMID: 29499561
5. the antitumor effects caused by TRPV4 channel inhibition in hepatocellular carcinoma cell lines might be attributed to the suppression of epithelial-mesenchymal transition process and inactivation of phospho-ERK which induced subsequent cell apoptosis. PMID: 29635900
6. Hypothermia-mediated increase in AQP4 surface abundance on human astrocytes, which was blocked using either calmodulin antagonist; TRPV4 antagonist or calcium chelation. A TRPV4 agonist mimicked the effect of hypothermia compared with untreated normothermic astrocytes. Hypothermia increased surface localization of AQP4 in human astrocytes likely through TRPV4 calcium channels and calmodulin activation. PMID: 28925524
7. our study suggests a role for compound heterozygosity and loss-of-function as a potential novel disease mechanism for this group of disorders. Profound intellectual disability was also noted in both affected children, suggesting that TRPV4 may be necessary for normal brain development. PMID: 28898540
8. Findings indicate that TRPV4 channels function as a critical component of mechano-sensitive, Ca2+-signaling machinery within the trabecular meshwork (TM), and that TRPV4-dependent cytoskeletal remodeling regulates TM stiffness and outflow. Thus, TRPV4 is a potential IOP sensor within the conventional outflow pathway. PMID: 27510430
9. These results identify an essential role of TRPV4 in flow shear stress-induced early osteogenic differentiation of human mesenchymal stem cells. PMID: 28501773
10. axonal colocalization of TRPV4 and TRPC6 was found in the digital Meissner corpuscles PMID: 27874267
11. TRPV4 is essential for human retinal capillary endothelial cell migration and tube formation, and maybe a potential therapeutic target for retinal vascular diseases. PMID: 29433476
12. TRPV4 is believed to be a mechanoreceptor in the bladder and is also involved in intercellular connectivity and structural integrity of the epithelium PMID: 27124500
13. this study, demonstrates for the first time that calcium exerts an oncogenic action in the stomach through activation of CaSR and TRPV4 channels. Both CaSR and TRPV4 were involved in Ca2+-induced proliferation, migration, and invasion of gastric cancer cells through a Ca2+/AKT/beta-catenin relay, which occurred only in gastric cancer cells or normal cells overexpressing CaSR. PMID: 28951460
14. TRPV4 involvement in RVD depends on the type of stimuli and/or degree of channel activation, leading to a maximum RVD response when Ca(2+) influx overcomes a threshold and activates further signaling pathways in cell volume regulation. PMID: 28098409
15. Studies demonstrate that TRPV4 play a leading function in many fibrotic disease. Increasing evidence shows that TRPV4 modulated fibroblasts proliferation and differentiation to myofibroblasts. While in cystic fibrosis, the defective regulatory volume decrease might be caused by the absence TRPV4 and in pancreatic fibrosis, TRPV4 serves as a sensor responsive to inflammation, hypotonic saline and pain. [review] PMID: 29126921
16. Arg594His substitution in TRPV4 causes SMD Kozlowski type. PMID: 28687525
17. Data show that transient receptor potential vanilloid 4 (TRPV4)expression is enhanced in a subset of basal breast cancers. PMID: 28759041
18. studies identified TRPV4 as a channel that contributes to both histamine- and chloroquine-induced itch and indicated that the function of TRPV4 in itch signaling involves TRPV1-mediated facilitation. PMID: 27436359
19. the results of this study suggest that clinical evaluation of patients with musculoskeletal disorders similar to the peripheral neuropathies or skeletal dysplasias with scoliosis that have been ascribed to the TRPV4 spectrum could consider whether the phenotypes might result from somatic mosaicism in the target tissues affected in these phenotypes. PMID: 27530454
20. A novel causative variant in the TRPV4 identified in a fetus with metatropic dysplasia in third trimester of pregnancy. PMID: 28414187
21. reduced tissue osmolarity, likely following proteoglycan degradation, can increase TRPV4 signalling and enhance pro-inflammatory cytokine production. PMID: 27434269
22. A novel TRPV4 mutation implicating TRPV4 and altered calcium homeostasis in the pathogenesis of osteonecrosis was identified while reinforcing the importance of TRPV4 in bone diseases and vascular endothelium. PMID: 27330106
23. both TRPV2 and TRPV4 are involved in migration of human cardiac c-kit(+) progenitor cells. PMID: 26865051
24. Data show that arylalkymine N-acetyltransferase (AANAT) levels and melatonin synthesis change after transient receptor potential channel 4 (TRPV4 channel) stimulation in ciliary body epithelial cells . PMID: 28368307
25. TRPV4-induced calcium mobilization and inflammatory responses were enhanced in cystic fibrosis transmembrane conductance regulator-deficient cellular models. PMID: 27496898
26. direct electrophysiological and pharmacological evidence for both TRPV4 and L-type Ca2+ conductances, as well as a tetraethylammonium (TEA)- and paxilline-sensitive K+ conductance in human pulmonary fibroblasts. PMID: 26851262
27. We demonstrate that pharmacological activation or inhibition of TRPV4 regulates Ca(2+)-wave propagation from head to tail. Such findings may have wide application in male fertility-infertility, contraception and conservation of endangered species as well. PMID: 27003252
28. These results confirm the function of TRPV4 in human cultured adipocytes and its regulation by insulin. PMID: 26381274
29. Helicobacter pylori infection-dependent DNA methylation suppressed TRPV4 expression in human gastric epithelia, suggesting that TRPV4 methylation may be involved in Helicobacter pylori-associated dyspepsia. PMID: 27687509
30. Phorbol myristate acetate increased TRPV4 expression in U937 and THP-1 cells. There was no significant difference in TRPV4 expression in the nLDL group but a significant reduction in TRPV4 expression was detected in the oxLDL group. PMID: 27706112
31. TRPV4 rs6606743 SNP was found to significantly contribute to the development of osmotic airway hyperresponsiveness in response to the decrease in osmolarity under inspiration of distilled water aerosol was studies in 189 patients with uncontrolled bronchial asthma, prevalence of AG + GG genotype frequency in the group of patients with asthma with osmotic hyperresponsiveness PMID: 27599507
32. Report of an Italian family with scapuloperoneal spinal muscular atrophy harboring the heterozygous missense mutation c.806G>A in the TRPV4 gene (p. R269H) and a literature review about scapuloperoneal spinal muscular atrophy PMID: 26948711
33. TRPV4 channel activity modulates uterine contractility and might represent a therapeutic target to address preterm labor. PMID: 26702092
34. In addition to the clear role TRPV4 plays in the growth plate, and its dysfunction leads to short-limbed and then short-trunked dwarfism, TRPV4 gain-of-function also leads to a state of increased bone turnover and osteopenia leading to fracture PMID: 26823048
35. This study demonstrated that the overexpression and distribution patterns of TRPV4 may be linked with the intractable epilepsy caused by tuberous sclerosis complex. PMID: 26874068
36. Overexpression and altered cellular distribution of TRPV4 observed in focal cortical dysplasia suggest that TRPV4 may potentially contribute to the epileptogenesis of focal cortical dysplasia PMID: 26842013
37. Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol PMID: 26294342
38. the activation of myenteric TRPV4 and the subsequent production of NO by these neurons have the potential to become an important target for the pharmacological treatment of GI disorders with predominant hypermotility symptoms. PMID: 26330151
39. these data strongly suggest endogenous TRPV4 channels as a mechanosensor, mediating cyclic stretch-induced realignment of hESC-CMs. PMID: 26259779
40. Identify TRPV4 as novel regulator of neutrophil activation and suggest contributions of both parenchymal and neutrophilic TRPV4 in the pathophysiology of acute lung injury. PMID: 26222277
41. TRPV4 regulates dynamics of trailing adhesions. PMID: 25559845
42. A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia. PMID: 26249260
43. Calcium sensitive TRPV4 translocation is associated with the regulation of endothelial response to mechanical stimulation. PMID: 26289129
44. The inflammatory cytokine TNF-a can modulate the activity of the mechanosensitive ion channels TRPA1 and TRPV4 in odontoblasts via the p38 MAPK pathway but has differential effects on their expression. PMID: 26358221
45. Interaction between the linker, pre-S1, and TRP domains determines folding, assembly, and trafficking of TRPV1 and TRPV4 channels. PMID: 26146187
46. Neurography revealed a late-onset sensory neuropathy in the father, which was so far not described in TRPV4 neuropathies. PMID: 26110311
47. P2Y1 couples to and activates TRPV4. PKC inhibitors prevented P2Y1 receptor activation of TRPV4. PMID: 26475857
48. Mutations in the transient receptor potential vanilloid 4 gene have a broad phenotypic variability and disease severity and may share a similar pathogenic mechanism with Heat Shock Protein related neuropathies. PMID: 25900305
49. Using multiple sequence alignments as source for evolutionary, bioinformatics and statistical analysis, we have analyzed the evolutionary profiles for TRPV1, TRPV2, TRPV3 and TRPV4 PMID: 25333484
50. sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns PMID: 24868547

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HGNC: 18083

OMIM: 113500

KEGG: hsa:59341

STRING: 9606.ENSP00000261740

UniGene: Hs.506713