Recombinant Macaca mulatta Interleukin-10 (IL10)
In Stock
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中文名称：
猕猴IL10重组蛋白
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货号：
CSB-MP011580MOW
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规格：
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图片：
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其他：
产品详情
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纯度：
Greater than 85% as determined by SDS-PAGE.
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基因名：
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Uniprot No.：
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别名：
IL10Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF
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种属：
Macaca mulatta (Rhesus macaque)
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蛋白长度：
Full Length of Mature Protein
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来源：
Mammalian cell
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分子量：
20.7kDa
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表达区域：
19-178aa
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氨基酸序列
SPGQGTQSENSCTRFPGNLPHMLRDLRDAFSRVKTFFQMKDQLDNILLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENHDPDIKEHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFSKLQEKGVYKAMSEFDIFINYIEAYMTMKIQN
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
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蛋白标签：
C-terminal 10xHis-tagged
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产品提供形式：
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
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缓冲液：
Tris-based buffer,50% glycerol
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储存条件：
Store at -20°C/-80°C upon receipt, aliquoting is necessary for
mutiple use. Avoid repeated freeze-thaw cycles.
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保质期：
The shelf life is related to many factors, storage state,
buffer ingredients, storage temperature and the stability of the protein
itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The
shelf life of lyophilized form is 12 months at -20°C/-80°C.
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货期：
3-7 business days
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注意事项：
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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产品描述：
This Recombinant Macaca mulatta IL10 protein was made through genetic engineering. By putting the IL10 gene into the genetic material of Mammalian cell cell, the Mammalian cell could be used as factories or producers to make the desired IL10 protein for research uses. The expression region of this protein is at 19-178aa. C-terminal 10xHis tag was used in the expression process. The purity is 85%+ determined by SDS-PAGE. IL-10 is the founding member of a family of cytokines. The involvement of IL-10 in many disease states has been demonstrated, both in animal models and in humans with mutations...
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Datasheet & COA：
Please contact us to get it.
靶点详情
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功能：
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-...
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基因功能参考文献：
- IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS, which may contribute to differences in the clinical presentation of NTS infection in the setting of malaria. PMID: 24670425
- Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis. PMID: 25165117
- IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha cytokine production. PMID: 23867612
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亚细胞定位：
Secreted.
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蛋白家族：
IL-10 family
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数据库链接：
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