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  4. Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (Plce1), partial

Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (Plce1), partial

  • 中文名称：
    小鼠Plce1重组蛋白
  • 货号：
    CSB-YP811721MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Plce1重组蛋白
  • 货号：
    CSB-EP811721MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Plce1重组蛋白
  • 货号：
    CSB-EP811721MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Plce1重组蛋白
  • 货号：
    CSB-BP811721MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Plce1重组蛋白
  • 货号：
    CSB-MP811721MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Plce1
  • Uniprot No.：
    Q8K4S1
  • 别名：
    Plce1; Kiaa1516; Plce; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; EC 3.1.4.11; Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1; PLC-epsilon-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formatio...显示更多
  • 基因功能参考文献：
    1. The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1. Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2 PMID: 27449513
    2. 2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 receptors. Among the six isoforms of phospholipase C (PLC; PLCbeta, PLCgamma, PLCdelta, PLCepsilon, PLCzeta, PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress... PMID: 28209735
    3. study shed light on a novel role of PLCepsilon in wound healing and provided new therapeutic approaches to target PLCepsilon for diminishing scar formation after injury PMID: 28093232
    4. PLCepsilon is crucial for N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis. PMID: 26782701
    5. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon. PMID: 26350460
    6. PLCepsilon plays an important role in the pathogenesis of bronchial asthma through upregulating inflammatory cytokine production by the bronchial epithelial cells. PMID: 25269075
    7. a new pathway for TRPC6 activation by Phospholipase C epsilon PMID: 25521631
    8. findings reveal a pathway initiated by GPCR agonist-induced RhoA activation, in which PLCepsilon signals to PKD1-mediated phosphorylation of cytoskeletal proteins PMID: 24345679
    9. Activity of PLCepsilon contributes to chemotaxis of fibroblasts towards PDGF. PMID: 22992460
    10. PLCepsilon links G protein-coupled receptors (GPCR) to sustained PKD activation, providing a means for GPCR ligands that couple to RhoA to induce NF-kappaB signaling and promote neuroinflammation. PMID: 23401561
    11. These results reveal a crucial role of PLCepsilon in the development of skin inflammation and suggest a mechanism in which PLCepsilon induces the production of cytokines including IL-23 from keratinocytes, leading to the activation of IL-22-producing T cells. PMID: 21182091
    12. results indicate that PLCvarepsilon has a crucial role in UVB-induced acute inflammatory reactions such as neutrophil infiltration and epidermal thickening by at least in part regulating expression of CXCL1/KC in skin cells such as keratinocytes and fibroblasts PMID: 21321537
    13. PLCepsilon may be a key molecule regulating the signal pathway of bladder cancer proliferation PMID: 21121899
    14. Phospholipase c-epsilon is a determinant of mouse islet insulin secretion that is under the control of Epac2. PMID: 21478675
    15. resistance to UVB-induced cell death conferred by the absence of PLCepsilon is closely related to the higher incidence of skin tumor formation. PMID: 20688835
    16. PLCepsilon plays a crucial role in induction of proinflammatory cytokine expression in fibroblasts and keratinocytes at the challenged sites PMID: 20007527
    17. the induction of phospholipase Cepsilon expression may be a specific event associated with the commitment of the neural precursor cells to the neuronal lineage. PMID: 12752375
    18. Phospholipase C epsilon acts downstream of the epidermal growth factor receptor in controlling semilunar valvulogenesis through inhibition of bone morphogenetic protein signaling. PMID: 15743817
    19. GPCR agonists ET-1, LPA, and thrombin activate PLCepsilon and PLCbeta3 in fibroblasts. Activation of these PLC isoforms displays agonist-specific temporal profiles; PLCbeta3 is predominantly involved in acute and PLCepsilon in sustained PI hydrolysis PMID: 16314422
    20. Phospholipase Cepsilon has a role in Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation PMID: 17878312
    21. PLC epsilon activation is involved in skin inflammation. PMID: 18172297
    22. control of sarcoplasmic reticulum Ca2+ release, rather than Ca2+ influx through L-type Ca2+ channels, is the target of regulation of a novel signal transduction pathway involving activation of Epac, PLCepsilon, PKCepsilon, and CamKII PMID: 18957419
    23. Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. PMID: 19458037

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Cell projection, lamellipodium.
  • 组织特异性：
    Highly expressed in neurons and to a lower extent in skin, skeletal muscle and heart (at protein level). Expressed in the epidermis.
  • 数据库链接：

    KEGG: mmu:74055

    STRING: 10090.ENSMUSP00000130604

    UniGene: Mm.34031

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