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  4. Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Plcg2), partial

Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Plcg2), partial

  • 中文名称：
    小鼠Plcg2重组蛋白
  • 货号：
    CSB-YP809299MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Plcg2重组蛋白
  • 货号：
    CSB-EP809299MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Plcg2重组蛋白
  • 货号：
    CSB-EP809299MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Plcg2重组蛋白
  • 货号：
    CSB-BP809299MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Plcg2重组蛋白
  • 货号：
    CSB-MP809299MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Plcg2
  • Uniprot No.：
    Q8CIH5
  • 别名：
    Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; EC 3.1.4.11; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-gamma-2; PLC-gamma-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
  • 基因功能参考文献：
    1. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis. PMID: 28786489
    2. Results show that mice with the mutated Plcg2 gene were less prone to transformation into MALT lymphomas as a result of elevated Treg numbers, and decrease of pro-inflammatory cytokines. PMID: 26966907
    3. PLCgamma2 in clear cells plays an essential role in luminal expansion of the epididymis during the prepubertal period in mice PMID: 26950550
    4. platelet activation through GPVI and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 levels are insufficient to support responsiveness, but that PLCgamma1 can restore responsiveness if expressed at levels normally achieved by PLCgamma2. PMID: 25793864
    5. amarogentin prevents platelet activation through the inhibition of PLC gamma2-PKC cascade and MAPK pathway PMID: 24868545
    6. PLCgamma2 and protein kinase C are important upstream signals that regulate myelopoiesis through cytokines. PMID: 24038146
    7. inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 domains of PLCgamma2. PMID: 24081142
    8. down-regulation of PLCgamma2-beta-catenin pathway occurs in mice and humans and leads to myeloid-derived suppressor cells-mediated tumor expansion. PMID: 24127488
    9. a novel role of the PLCgamma2-IP(3)-Ca(2+) cascade in the LPS-induced innate immune response pathway where release of intracellular Ca(2+) mediates TLR4 trafficking and subsequent activation of IRF3. PMID: 22158869
    10. VapB positively regulates RANKL-mediated osteoclastogenesis via PLCgamma2-Ca(2+)-NFAT signaling PMID: 22245675
    11. PLCgamma2 deficiency impairs Dectin-2-induced NF-kappaB and MAPK activation in response to fungal infection PMID: 22041900
    12. These results suggest that the Plcg2-mediated pathways play a crucial role in various metabolic and sperm functions, in addition to initiating and maintaining the immune system. PMID: 21305534
    13. Data indicate a role for PLCgamma2 and Ca(2+) signaling through the modulation of MEK/ERK in IL3/GM-csf stimulated mouse hematopoietic stem/progenitor cells. PMID: 21506110
    14. Phosphatidylinositol-specific phospholipase C (PLC)-gamma was identified as a partner of the Spry1 and Spry2 proteins. PMID: 20719962
    15. results demonstrate that the enzymatic activity of PLCgamma2 is tightly regulated to ensure efficient but limited platelet activation at sites of vascular injury PMID: 20230420
    16. over expression of SH3BP2 in RAW 264.7 cells potentiates sRANKL-stimulated phosphorylation of PLCgamma1 and PLCgamma2. PMID: 20872577
    17. Integrin alphaIIbbeta3 signaling via Src family kinases and Syk kinase to PLCgamma2 is required for megakaryocyte spreading, migration, and platelet formation. PMID: 20457868
    18. study demonstrates a critical role for PLCgamma2 in eliciting inflammatory responses by regulating actin dynamics in DCs and positions the PLCgamma2 pathway as a common orchestrator of bone and immune cell functions during arthritis PMID: 20111715
    19. PLCgamma2 is a critical regulator of the cellular and molecular mechanisms occurring in bone and immune cells during autoimmune inflammation. PMID: 20392227
    20. The signaling pathway downstream of Syk divides into PLC2- and PI3K-dependent pathways. The activation of these pathways is controlled by the Tec family kinase Btk, which is required for E-selectin-mediated slow rolling. PMID: 20167705
    21. Swip-1 provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent BCR-induced calcium flux. PMID: 20194721
    22. Activation by GPVI and thrombin was unaltered in Vav1-, Vav2-, and Vav1/Vav2-deficient platelets. PMID: 12411320
    23. PLC gamma 2 is expressed in mast cells and monocytes/macrophages and is activated by cross-linking of Fc epsilon and Fc gamma receptors. PMID: 12471105
    24. PLC gamma 2 is not required for platelet aggregation. PMID: 12729897
    25. PLCG2 has a signaling role in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization PMID: 12813055
    26. PLCgamma2 plays not only a crucial role in activation of alphaIIbbeta3 by collagen receptors but also in alphaIIbbeta3-mediated responses. PMID: 12832411
    27. the PLCgamma2 pathway provides a survival signal via regulation of Bcl-2 in all splenic B cell subpopulations and via additional induction of A1 in mature FO B cells PMID: 12928432
    28. phospholipase C-gamma2 regulates RasGRP3 localization and thereby Ras activation. PMID: 14676298
    29. While absence of PLCgamma2 had only a minimal effect on platelet adhesion to immobilized von Willebrand factor, its absence impaired spreading and profoundly affected thrombus growth and stability on VWF PMID: 15327970
    30. results demonstrate that Vav3 and Vav1 play crucial but redundant roles in the activation of phospholipase C gamma 2 by glycoprotein GPVI PMID: 15456756
    31. PLC-gamma2 is phosphorylated on Y753, Y759, and Y1217 in response to engagement of the B-cell receptor PMID: 15509800
    32. signaling through PLCgamma2 plays an important role in arterial thrombosis, but that its contribution depends on the severity of the vascular lesion PMID: 15774906
    33. M-CSF induces the translocation of PCLgamma2 to the cell membrane PMID: 15899577
    34. Phospholipase C gamma 2 is crucial for development of the natural killer (NK) cell receptor repertoire and signaling of activating NK cell receptors, mediating optimal NK cell function in vivo. PMID: 16002670
    35. The GPVI-PLCgamma2 activation pathway regulates collagen-dependent coagulation in venous and arterial thrombus formation. PMID: 16254207
    36. Whereas PI3K functions upstream of PLCgamma2, activation of PLCgamma2 can occur independently of PI3K and that PI3K and PLCgamma2 also have distinct functions in BCR signal transduction. PMID: 16354682
    37. BLNK-/- PLCgamma2-/- mice had compounded defects in B cell maturation compared with either single mutant, suggesting that these two molecules cooperatively or synergistically signaled B lymphopoiesis. PMID: 16585562
    38. PLCgamma1 and PLCgamma2 play nonredundant and obligatory roles in NK cell ontogeny and in its effector functions. PMID: 17015722
    39. Plays an important role in pre-B cell receptor-mediated early B-cell development. PMID: 17030619
    40. in osteoclasts, PLCgamma2 formed a complex with the regulatory adapter molecule GAB2, was required for GAB2 phosphorylation, and modulated GAB2 recruitment to receptor activator of NF-kappaB PMID: 17053833
    41. Bruton's tyrosine kinase and phospholipase C gamma 2 act both in concert and independently throughout B cell development. PMID: 17372989
    42. activation of PLCgamma2 via glycoprotein 6 is dependent on 2 complementary events PMID: 17579183
    43. Data demonstrate that the phospholipase Cgamma2 signaling pathway plays a role in activation of light-chain loci and contributes to receptor editing. PMID: 17591700
    44. Data suggest that both the Vav family of Rho GTPase guanine nucleotide exchange factors and phospholipase C-gamma2 are critical mediators of adhesion-dependent reactive oxygen intermediate production by neutrophils in mice. PMID: 17932569
    45. A key role for phospholipase C-gamma2 (PLCgamma2), Vav, B cell linker, and Bruton's tyrosine kinase in the formation of highly coordinated "microsignalosomes," , is identified.[ PMID: 18362175
    46. PLCgamma2 influences Src activation by mediating the localization of Src to the integrin complex and thereby regulating integrin-mediated functions in the osteoclast. PMID: 18378693
    47. GPVI-FcR gamma-chain, LAT and PLCgamma2 are essential for thrombus generation and stability PMID: 18464161
    48. results demonstrate that Rac1 is essential for immunoreceptor tyrosine-based activation motif-dependent PLCgamma2 activation in platelets and that this is critical for thrombus formation in vivo PMID: 18704487
    49. PLCgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis PMID: 18728019
    50. The blood-lymph shunt observed in PLCgamma2-null mice was due to aberrant separation of blood and lymphatic vessels. A similar phenotype was observed in lethally irradiated wild-type mice reconstituted with PLCgamma2-null bone marrow cells. PMID: 19056831

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  • 数据库链接：

    KEGG: mmu:234779

    STRING: 10090.ENSMUSP00000079991

    UniGene: Mm.192699

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