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  4. Recombinant Mouse ADP-ribosylation factor 6 (Arf6)

Recombinant Mouse ADP-ribosylation factor 6 (Arf6)

  • 中文名称：
    Recombinant Mouse ADP-ribosylation factor 6(Arf6)
  • 货号：
    CSB-YP001996MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse ADP-ribosylation factor 6(Arf6)
  • 货号：
    CSB-EP001996MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse ADP-ribosylation factor 6(Arf6)
  • 货号：
    CSB-EP001996MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse ADP-ribosylation factor 6(Arf6)
  • 货号：
    CSB-BP001996MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse ADP-ribosylation factor 6(Arf6)
  • 货号：
    CSB-MP001996MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Arf6
  • Uniprot No.：
    P62331
  • 别名：
    Arf6ADP-ribosylation factor 6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-175
  • 氨基酸序列
    GKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE TVTYKNVKFN VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR QELHRIINDR EMRDAIILIF ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY VQPSCATSGD GLYEGLTWLT SNYKS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early end...显示更多
  • 基因功能参考文献：
    1. accumulation of free cholesterol in late endosomes/lysosomes of Arf6 knockout mouse embryonic fibroblasts results from mistrafficking of Niemann-Pick type C protein NPC2 PMID: 27336679
    2. results indicated that Arf6 was involved in mouse oocyte meiosis through its functional roles in actin-mediated spindle movement and spindle organization. PMID: 29208529
    3. This study identifies a novel regulatory crosstalk between Ral and Arf6 that controls Ral function in cells. PMID: 27269287
    4. The present study demonstrated that the Arf6-specific GAP ACAP3 plays a crucial role in neuronal migration through regulating morphological changes of neurons at intermediate zone of developing cerebral cortex. PMID: 28919417
    5. Study demonstrates that Arf6 regulates neuronal migration in the intermediate zone through the FIP3-dependent trafficking of endosomes containing N-cadherin during cortical layer formation. PMID: 27622210
    6. The results show that ARNO interaction with the RLIP76 N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 control of Rac. PMID: 25450693
    7. The present study provided evidence that BRAG2a is a novel component of the photoreceptor dystrophin-associated glycoprotein complex (DGC), suggesting functional involvement of the BRAG2a-Arf6 pathway downstream of the DGC. PMID: 28744553
    8. Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking. PMID: 28495929
    9. cycling between active and inactive forms of Arf6, which is precisely regulated by ACAP3 in concert with a guanine-nucleotide-exchange factor(s), seems to be required for neurite outgrowth of hippocampal neurons PMID: 27330119
    10. ARF6-dependent pathway is the predominant route responsible for the ABCA1 internalization and degradation, whereas ARF6-independent endocytic pathways may contribute to ABCA1 recycling and efflux of intracellular cholesterol. PMID: 27758770
    11. These findings suggest that SDCCAG3 might function in endosomal trafficking downstream of Arf6. PMID: 27373827
    12. both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses. PMID: 26884337
    13. Peripheral ARNO promotes clathrin assembly through its GEF activity for Arf6. PMID: 26683831
    14. In platelet-specific Arf6 knockout mice,Arf6 KO platelets had less associated Fg suggesting that Arf6 affects alphaIIbbeta3-mediated Fg uptake and/or storage. They were also defective in FITC-Fg uptake and storage. PMID: 26738539
    15. findings show for the first time that Ang II receptor signaling to beta-arrestin regulates ARF6 activation. These proteins together control receptor endocytosis and ultimately cell migration. PMID: 26703465
    16. The role of ARF-6 and Annexin A2 in the invasion of mammalian cells by T. cruzi amastigotes. PMID: 26416603
    17. Findings demonstrate that Arf6 in neurons of the CNS plays an important role in oligodendrocyte precursor cells migration by regulating secretion of FGF-2 from neurons, thereby contributing to the axon myelination. PMID: 26291245
    18. RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. PMID: 26498519
    19. Arf6 is required for hepatocyte growth factor (HGF)-induced tumour neoangiogenesis and growth. PMID: 26239146
    20. the activation-inactivation cycles of Rab35 and ARF6 are required for the uptake of zymosan and that ACAP2 is an important component that links Rab35/ARF6 signaling during phagocytosis of zymosan. PMID: 26229970
    21. Arf6 plays an important role in oligodendrocyte precursor cells migration through regulation of FGF-2 secretion during neuronal development. PMID: 25144208
    22. These results suggest that signaling through Arf6 is required for Schwann cell myelination, adding Arf6 to the list of intracellular signaling molecules involved in the myelination process. PMID: 26277388
    23. results together suggest that cytohesin 2 activates ARF6 in a PI3K dependent manner and then the active ARF6 causes phosphorylation of ERK1/2 during preadipocyte migration. PMID: 25450674
    24. JSAP1 and JLP, which might be paralogous to each other, are critical and functionally redundant in cytokinesis and control ARF6 localization to the midbody by forming a tripartite complex of JSAP1/JLP, active ARF6, and kinesin-1. PMID: 25130574
    25. Cytohesin-2 constitutively suppresses platelet dense granule secretion and aggregation by keeping ARF6 in a GTP-bound state PMID: 24581425
    26. studies also revealed that ARF6 acts upstream of ERK in ET-1-indcued lipolysis. In summary, we determined that ET-1 activation of ETAR signalled through ARF6, which is crucial for lipolysis PMID: 24955982
    27. MyD88-ARNO-ARF6-signaling axis is responsible for LPS-induced endothelial permeability and is a destabilizing convergence point used by multiple inflammatory cues PMID: 24835390
    28. Arf6 mediates neurite formation through the interaction with SNX1 which is regulated by EFA6A. PMID: 24261326
    29. a critical role for Arf6 in regulating Tram/Trif-dependent TLR4 signaling. PMID: 24297182
    30. The CYTH2 and ACTN1 properly regulates neurite extension in N1E-115 cells, demonstrating the unexpected interaction of CYTH2 and ACTN1 in the regulation of cellular Arf6 activity involved in neurite extension. PMID: 22659138
    31. The effector Arf6 protein is required for migration of primary Schwann cells. PMID: 23517829
    32. MuSK colocalizes with actin and Arf6 at the cell surface and during endosomal trafficking. PMID: 23621612
    33. Our studies implicate the small regulatory GTPase Arf6 in the endocytic trafficking of Pasteurella multocida toxin. PMID: 22053287
    34. Arf6 is responsible for alpha5beta1-integrin recycling and thereby completes the cycle of syndecan-4-regulated integrin trafficking. PMID: 22790193
    35. It was shown that, during cytokinesis, Arf6 is first accumulated around the cleavage furrow and, prior to abscission, recruited onto the Flemming body via interaction with MKLP1. PMID: 22522702
    36. Immunofluorescence demonstrated that the tubules were plasma membrane invaginations resulting from an ADP-ribosylation factor 6 (ARF6)-dependent and clathrin-independent pathway. PMID: 21883766
    37. a novel class III PI3K-ARF6 axis pathway mediates TLR9 signaling by regulating the cellular uptake of CpG ODN. PMID: 22170068
    38. These results demonstrate a spatial separation between APP and BACE1 during surface-to-endosome transport, suggesting subcellular trafficking as a regulatory mechanism for this proteolytic processing step. PMID: 21825135
    39. Under Chol(-) conditions, AChR internalization requires the activity of Arf6 and its effectors Rac1 and phospholipase D PMID: 21357688
    40. Results suggest that the expression of Arf6 in mouse tissues is precisely regulated in a development- and tissue-dependent manner. PMID: 21069828
    41. ARF6 is a critical regulator of C2C12 myoblast fusion and participates in the regulation of PLD activities that trigger both phospholipids production and actin cytoskeleton reorganization at fusion sites. PMID: 20505075
    42. Two compound heterozygous missense mutations (D147H and A509V) in TBC1D24, a gene of unknown function, are responsible for familial infantile myoclonic epilepsy. PMID: 20727515
    43. cytohesin-2, through a previously unexplored complex formation with paxillin, regulates preadipocyte migration; paxillin plays a previously unknown role as a scaffold protein of Arf guanine-nucleotide exchange factor PMID: 20525696
    44. AMPA receptor signaling through Arf6 (and BRAG2) is critical for long-term synaptic depression. PMID: 20547133
    45. cellular prion protein is internalized in a clathrin-independent pathway that is associated with Arf6 PMID: 19843586
    46. The results provide evidence that ARF6/JIP3 signaling regulates neurite morphogenesis. PMID: 20493856
    47. Sema3E acts on plexin D1 to initiate a two-pronged mechanism involving R-Ras inactivation and Arf6 stimulation, which affect the status of activation of integrins and their intracellular trafficking, respectively. PMID: 20385769
    48. Results suggest a role of the endocytic pathway and its regulation by Arf6 in adrenergic stimulation of lipolysis in adipocytes and potentially in the development of obesity. PMID: 20107045
    49. ARF6 is activated by H-Ras, which along with RalA, leads to phospholipase D activation PMID: 12509462
    50. ARF6 is activated in macrophages when phagocytosis is initiated via receptors for the Fc portion of immunoglobulins (FcRs). A dominant-negative mutant of ARF6 dramatically affected FcR-mediated phagocytosis. PMID: 12810696

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, ruffle. Cleavage furrow. Midbody, Midbody ring. Early endosome membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor.
  • 蛋白家族：
    Small GTPase superfamily, Arf family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:11845

    STRING: 10090.ENSMUSP00000055862

    UniGene: Mm.27308

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