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  4. Recombinant Mouse Adenylate cyclase type 3 (Adcy3), partial

Recombinant Mouse Adenylate cyclase type 3 (Adcy3), partial

  • 中文名称：
    Recombinant Mouse Adenylate cyclase type 3(Adcy3) ,partial
  • 货号：
    CSB-YP840868MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylate cyclase type 3(Adcy3) ,partial
  • 货号：
    CSB-EP840868MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylate cyclase type 3(Adcy3) ,partial
  • 货号：
    CSB-EP840868MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylate cyclase type 3(Adcy3) ,partial
  • 货号：
    CSB-BP840868MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Adenylate cyclase type 3(Adcy3) ,partial
  • 货号：
    CSB-MP840868MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Adcy3
  • Uniprot No.：
    Q8VHH7
  • 别名：
    Adcy3; Adenylate cyclase type 3; EC 4.6.1.1; ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase; olfactive type; Adenylyl cyclase 3; AC3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
  • 基因功能参考文献：
    1. Cell apoptosis in the testicular tissues of AC3(-/-) mice increased significantly compared with that in wild-type (AC3(+/+)) mice. The expression of 693 genes was altered in the testicular tissues of AC3(-/-) mice, including 330 up-regulated and 363 down-regulated gene expression, helping to elucidate the mechanisms underlying the sterility in AC3(-/-) male mice. PMID: 27864010
    2. AC3 may play a role in proximal olfactory signaling and play a role in the regulation of differentially expressed genes in mouse MOE. PMID: 26633363
    3. genetic ablation of adenylate cyclase III has drastic, location-dependent effects on cilia architecture in the mouse nose PMID: 26942602
    4. Data showed the presence mRNA of obligated downstream components of olfactory receptor signaling adenylyl cyclase 3 and olfactory G protein in the cerebral cortex of the mouse. PMID: 23817016
    5. increased Adcy3 activity robustly protect animals from diet-induced metabolic derangements PMID: 25329148
    6. Coexpression of serotonin receptor 5HT6 with adenylyl cyclase type III normalizes cilia structure and restores dendrite outgrowth. PMID: 23392690
    7. Data suggest that while ADCY3 is responsible for a share of the cAMP in osteoclasts, the reduction of cAMP levels in the absence of this gene is insufficient to augment differentiation or effect changes in bone mass in vivo. PMID: 22985540
    8. We conclude that AC3 in the main olfactory epithelium is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing. PMID: 23136416
    9. In primary culture and in situ in G93A SOD1 mice there is a large reduction in the proportion of motor neurons bearing a primary cilium. PMID: 21767396
    10. Maternal behavior was impaired in female mice deficient in adenylyl cyclase 3. PMID: 21150908
    11. AC3(-/-) mice show no short-term memory for novel objects and fail to exhibit extinction of contextual fear conditioning PMID: 21490195
    12. GSK3beta inactivation or deletion reduces aquaporin 2 expression by modulating adenylate cyclase activity and cAMP generation, thereby impairing responses to vasopressin in the renal collecting duct PMID: 20056751
    13. cAMP signals generated by AC3 in the hypothalamus may play a critical role in regulation of body weight PMID: 19750222
    14. adenylyl cyclase 3 is functional in rodent oocytes and its activity is involved in the control of oocyte meiotic arrest PMID: 12798295
    15. required for normal spermatid or spermatozoa function and male fertility PMID: 15705663
    16. point to a major role played by a crucial element of the odorant-induced transduction cascade, adenylyl cyclase 3, in the targeting of olfactory sensory neuron axons towards the brain PMID: 17537788
    17. There was robust Adcy3 expression in both olfactory sensory neuron cilia and axons during the period of active glomerular formation in neonatal transgenic mice. PMID: 17581954

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Golgi apparatus. Cytoplasm.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 组织特异性：
    Detected in the acrosomal region of epididymal spermatozoa, the acrosomal region of round spermatids and in elongating spermatids. Detected in cilia in the olfactory epithelium (at protein level). Detected in olfactory epithelium neurons. Detected in brai
  • 数据库链接：

    KEGG: mmu:104111

    STRING: 10090.ENSMUSP00000020984

    UniGene: Mm.489807

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