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  4. Recombinant Mouse Alpha-actinin-1 (Actn1), partial

Recombinant Mouse Alpha-actinin-1 (Actn1), partial

  • 中文名称：
    Recombinant Mouse Alpha-actinin-1 (Actn1), partial
  • 货号：
    CSB-EP766510MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Actn1
  • Uniprot No.：
    Q7TPR4
  • 别名：
    Alpha-actinin cytoskeletal isoform;F-actin cross-linking protein;Non-muscle alpha-actinin-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    32.0 kDa
  • 表达区域：
    31-250aa
  • 氨基酸序列
    KQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Actn1 Proteins

靶点详情

  • 功能：
    F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
  • 基因功能参考文献：
    1. The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression. PMID: 28682694
    2. These findings evidence alpha-actinin involvement in sarcomeric development, suggesting for this protein an important role in stabilizing the muscle contractile apparatus. PMID: 25262166
    3. The C-terminal polybasic region of CYTH2 participates in interacting directly with the EFh2 domain of ACTN1. PMID: 22659138
    4. Actn1 differential methylation occurs in diverse mouse tissues. Authors have found no indication of an imprinted effect on gene expression of Actn1 in mice. PMID: 23145029
    5. alpha-actinin has a role in adhesion maturation through integrin-dependent force transmission to the extracellular matrix PMID: 23515331
    6. Alpha-actinin interaction with syndecan-4 has a role in stabilising cell-matrix adhesion. PMID: 22940199
    7. the SRF-cofilin-actin signaling axis modulates neuronal mitochondrial function PMID: 22927399
    8. vinculin engagement of adhesion receptors first activates talin or alpha-actinin, by provoking structural changes that allow their vinculin binding sites to swing out, which are then sufficient to bind to and activate vinculin PMID: 16407299

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane. Cell junction. Cell projection, ruffle.
  • 蛋白家族：
    Alpha-actinin family
  • 数据库链接：

    KEGG: mmu:109711

    STRING: 10090.ENSMUSP00000021554

    UniGene: Mm.253564

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