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  4. Recombinant Mouse Angiotensin-converting enzyme (Ace), partial

Recombinant Mouse Angiotensin-converting enzyme (Ace), partial

  • 中文名称：
    Recombinant Mouse Angiotensin-converting enzyme(Ace) ,partial
  • 货号：
    CSB-YP001149MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Angiotensin-converting enzyme(Ace) ,partial
  • 货号：
    CSB-EP001149MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Angiotensin-converting enzyme(Ace) ,partial
  • 货号：
    CSB-EP001149MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Angiotensin-converting enzyme(Ace) ,partial
  • 货号：
    CSB-BP001149MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Angiotensin-converting enzyme(Ace) ,partial
  • 货号：
    CSB-MP001149MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ace
  • Uniprot No.：
    P09470
  • 别名：
    Ace; Dcp1Angiotensin-converting enzyme; ACE; EC 3.2.1.-; EC 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme; soluble form]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.
  • 基因功能参考文献：
    1. ACE expression/phosphorylation in the bone-marrow niche interface negatively regulates G-CSF-induced signaling and hematopoietic progenitor cell mobilization. PMID: 29549541
    2. first evidence indicating the causation between ACE DD or B2R+9bp genotype and the increased risk for diabetic nephropathy, broadening our horizon about the role of genetic modulators in this disease. PMID: 28390948
    3. a small increase in angiotensin-converting enzyme activity in diabetic animals leads to greater impairment of autonomic function, as demonstrated by increased sympathetic modulation and reduced cardiac vagal modulation along with increased renal expression of Ang II. PMID: 30088535
    4. Resveratrol upregulated ACE2 and inhibited abdominal aortic aneurysm growth in a mouse model. PMID: 28935757
    5. In mice with renal injury induced by L-NAME pretreatment, renal tubular epithelial ACE is essential for renal angiotensin II accumulation and salt-sensitive hypertension PMID: 27988209
    6. Studied ACE role in peptide processing and for MHC class II antigen presentation; found ACE level effects efficiency of antigen presentation, and overexpression or inhibition of ACE alters the CD4(+) T-cell and antibody response. PMID: 28394320
    7. ACE enhances the oxidative response and bactericidal activity of neutrophils. PMID: 28515091
    8. this study shows that angiotensin-converting enzyme inhibitor captopril rescues mice from endotoxin-induced lethal hepatitis PMID: 27879415
    9. Smooth muscle cell-derived ACE contributes to atherosclerosis, independent of circulating ACE activity and blood pressure. PMID: 27055902
    10. Intestinal ACE shedding is increased by DSS-induced intestinal inflammation and parallels local corticosterone production. ACE product angiotensin II stimulates corticosterone formation in healthy intestine. PMID: 26401072
    11. Renin angiostensin system contributes to 20-HETE-mediated microvascular remodeling in hypertension and that 20-HETE-driven microvascular remodeling independent of blood pressure elevation does not fully rely on ACE activity in the vascular endothelium. PMID: 25924878
    12. angiotensin-converting enzyme has an essential role in hypertension induced by nitric oxide synthesis inhibition PMID: 25012170
    13. Suggest that the ACE2-ACE imbalance plays an important role in the pathogenesis of severe acute pancreatitis and that pancreatic ACE2 is an important factor in determining the severity of SAP. PMID: 24414175
    14. Show that tissue-specific targets are critical for the effects of miR-143/145 on smooth muscle differentiation and that angiotensin converting enzyme is one such target. PMID: 25273883
    15. Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice. PMID: 24475296
    16. ACE-null mice produce large numbers of myeloid-derived suppressor cells during chronic inflammation. PMID: 24614194
    17. Myelomonocytic expression of catalytically active ACE, prevents cognitive decline in a murine model of Alzheimer disease. PMID: 24487585
    18. ACE mediates angiotensin I-induced atherosclerosis, and ACE expression in leukocytes modestly contributes to atherosclerotic development in hypercholesterolemic mice. PMID: 23846498
    19. TEX101 is a unique specific substrate for ACE that is essential for the production of fertile mouse spermatozoa PMID: 23633567
    20. renal ACE activity is required to increase local Ang II, to stimulate sodium transport in loop of Henle and the distal nephron, and to induce hypertension PMID: 23619363
    21. deregulation of ACE and ACE2 plays an important role in tourniquet-induced renal injury PMID: 22580272
    22. When Ang I and CMP48/80 were co-administered, AT(1B) receptor expression was increased, MCP-4 was found surrounding the vessel wall PMID: 21622682
    23. shapes the MHC class I peptide repertoire for antigen presentation to T-cells PMID: 21964607
    24. Mature adipocytes modulate the expression profile of macrophages by releasing lipid mediators that increase ACE expression. PMID: 21116821
    25. results demonstrate a previous unrecognized significant role for ACE in myelopoiesis and imply new perspectives for manipulating myeloid cell expansion and maturation. PMID: 21148418
    26. Leptin regulates ACE activity in mice PMID: 20614101
    27. Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus PMID: 20937811
    28. A modest genetic increase in ACE impairs myocardial tolerance to ischemia. ACE level plays a critical role in cardiac ischemia, through both kinin and angiotensin mediated mechanisms. PMID: 20667972
    29. data provide direct evidence that small genetic disturbances in ACE levels per se have an influence on haemodynamic, cardiac mass and autonomic nervous system responses in mice under pathological perturbation PMID: 19930431
    30. angiotensin-converting enzyme has a role in improving autonomic dysregulation in ob/ob mice PMID: 20012594
    31. data suggest that the two catalytic domains of mACE do not function independently but that the signal transduction is influenced by negative cooperativity of the two catalytic domains PMID: 20030584
    32. There is a switch from ACE-dependent to serine protease-dependent ANG II formation in the type II diabetic kidney. PMID: 19846569
    33. data suggest that ACE is essential to ANG II formation in the vascular space PMID: 12003835
    34. urine-concentrating defect in mice with absence of tissue ACE is associated with downregulation of key urea, salt, and water transport proteins PMID: 12167603
    35. Chymase may play a role in heart remodeling by increasing Ang II formation and activating MMP-9, and the regulation of collagen I gene expression. PMID: 12359984
    36. gender differences in expression of ACE in the heart PMID: 12384478
    37. results demonstrated that the rodent germinal angiotensin converting enzyme is released from the testicular sperm membrane when sperm enter the epididymis PMID: 12444051
    38. There is no any association between angiotensin converting enzyme polymorphism and Alzheimer's disease. PMID: 12459519
    39. Substantial evidence is provided for a major role for angiotensin converting enzyme in a murine allergic contact dermatitis model of neurogenic infolammation. PMID: 12646655
    40. Expression of ACE, either in renal proximal tubules or in vasculature, is sufficient for maintaining normal kidney functions, but for maintaining blood pressure, ACE must be expressed in vascular endothelial cells. PMID: 12777443
    41. the presence of the C-terminal ACE catalytic domain is sufficient to maintain a functional renin-angiotensin system PMID: 14757757
    42. ACE is the predominant pathway of angiotensin II formation in blood and tissues of mice and plays a major role in bradykinin (1-9) metabolism in blood and, to a lesser extent, in kidney and heart. PMID: 14769811
    43. t-ACE contributes to arterial structure/remodeling & hyperplastic carotid inward remodeling from blood flow cessation. It is not needed for outward hypertrophic & subsequent inward hypotrophic remodeling of the uterine artery during/after pregnancy. PMID: 15031129
    44. Aldosterone upregulated macrophage ACE mRNA expression and activity. The selective effect of aldosterone on tissue ACE, versus circulating ACE, further demonstrates differences in the regulation pathways of tissue and circulating ACE. PMID: 15123520
    45. ACE Tyr phosphorylation, probably in the endoplasmic reticulum, enhances the rate of its cleavage secretion at the plasma membrane using a regulatory pathway that may involve p38 MAP kinase PMID: 15252021
    46. Mice with cardiac-restricted angiotensin-converting enzyme have atrial enlargement, cardiac arrhythmia, and sudden death. PMID: 15331425
    47. Ptn has the potential to critically regulate the downstream activities of angiotensin II, through the regulation of its synthesis by ACE and its receptor mediated functions through regulation of both the AT1 and AT2 receptors PMID: 15485659
    48. renal tissue angiotensin converting enzyme is an important contributor to tubuloglomerular feedback PMID: 15494545
    49. ACE is associated with body weight and peri-epididymal fat accumulation PMID: 15522949
    50. ACE signaling may underlie the increase in COX-2 and prostacyclin levels in patients treated with ACE inhibitors. PMID: 15569856

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  • 亚细胞定位：
    [Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Detected in both cell membrane and cytoplasm in neurons.
  • 蛋白家族：
    Peptidase M2 family
  • 组织特异性：
    Testis-specific isoform is expressed in spermatocytes, adult testis.
  • 数据库链接：

    KEGG: mmu:11421

    STRING: 10090.ENSMUSP00000001963

    UniGene: Mm.754

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