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  4. Recombinant Mouse Cystic fibrosis transmembrane conductance regulator (Cftr), partial

Recombinant Mouse Cystic fibrosis transmembrane conductance regulator (Cftr), partial

  • 中文名称：
    Recombinant Mouse Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-YP005292MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-EP005292MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-EP005292MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-BP005292MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cystic fibrosis transmembrane conductance regulator(Cftr) ,partial
  • 货号：
    CSB-MP005292MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cftr
  • Uniprot No.：
    P26361
  • 别名：
    Cftr; Abcc7; Cystic fibrosis transmembrane conductance regulator; CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; EC 5.6.1.6; cAMP-dependent chloride channel
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the...显示更多
  • 基因功能参考文献：
    1. Results show that CFTR channels are present in alpha cells and act as important negative regulators of cAMP-enhanced glucagon secretion through effects on alpha cell membrane potential. These data support that loss-of-function mutations in CFTR contributes to dysregulated glucagon secretion in Cystic Fibrosis-related diabetes. PMID: 28273890
    2. these results demonstrate that CFTR prevents inflammation and atherogenesis via inhibition of NFkappaB and MAPKs activation PMID: 28615349
    3. CFTR physically interacts with beta-catenin, defect of which leads to premature degradation of beta-catenin and suppressed activation of beta-catenin signaling. PMID: 27834953
    4. CFTR attaches tumor suppressor PTEN to the membrane and promotes anti Pseudomonas aeruginosa immunity. PMID: 29246444
    5. Our studies reveal a novel function for CFTR in antiviral immunity and demonstrate that the DeltaF508 mutation in cftr is coupled to an impaired adaptive immune response. This important insight could open up new approaches for patient care and treatment. PMID: 28968805
    6. a new and more convenient approach, based on in vivo imaging analysis, has been set up to evaluate the inflammatory response in the lung of CFTR-deficient (CF) mice, a murine model of cystic fibrosis. PMID: 27468800
    7. results reveal that by potentiating adenosine triphosphate-sensitive K+ (KATP) channel, cystic fibrosis transmembrane conductance regulator CFTR acts as a glucose-sensing negative regulator of glucagon secretion in alpha cells PMID: 28977595
    8. This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway. PMID: 28495756
    9. CFTR is a tumor suppressor gene in murine and human colorectal cancer PMID: 26751771
    10. Insulin stimulation of Akt1 and Akt2 signaling in Cystic fibrosis airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR. PMID: 28213469
    11. Biotinylation and streptavidin pull-down assays confirmed that CAL dramatically reduces the expression level of total and cell surface Mrp2 in Huh-7 cells. Our findings suggest that CAL interacts with Mrp2 and is a negative regulator of Mrp2 expression. PMID: 27834195
    12. Myelinosomes secreted from testis somatic TM4 Sertoli cells provide the release of aggregate-prone mutant, but not normal Huntingtin (Htt) exon1. Myelinosomes also support the release of other aggregate-prone mutant protein responsible for cystic fibrosis (CF), F508delCFTR. PMID: 27493027
    13. ATP8B1 is important for proper CFTR expression and function. PMID: 27301931
    14. Loss of cystic fibrosis transmembrane regulator impairs intestinal oxalate secretion PMID: 27313231
    15. CFTR plays a role in suppressing MAPK/NF-kappaB to relieve inflammation, reduce proliferation and promote differentiation of keratinocytes, and thus promotes cutaneous wound healing. PMID: 27832634
    16. CFTR expressed by alveolar or peritoneal macrophages regulates acute proinflammatory responses. PMID: 25778108
    17. CFTR silencing in pancreatic beta-cells significantly reduced insulin output in response to glucose, and made the cells more sensitive to oxidative stress. PMID: 26625901
    18. Cftr KO crypt epithelium maintains an alkaline pHi as a consequence of losing both Cl(-) and HCO3 (-) efflux, which impairs pHi regulation by Ae2. PMID: 26542396
    19. Data suggest that the deltaF508 Cftr mutation (the most frequent CFTR mutation in cystic fibrosis in humans) is associated with worsening insulin resistance and down-regulation of insulin secretion from pancreatic beta cells as mutant mice age. PMID: 26283735
    20. Second-hand cigarette impairs bacterial phagocytosis by modulating CFTR dependent lipid-rafts. PMID: 25794013
    21. CFTR Cl- channel is a molecular target of natural compounds EGCG and ECG. PMID: 25747701
    22. results suggest that mCFTR pharmacological sensitivities differ from hCFTR, which will provide a useful tool for identifying the binding sites and mechanism for these potentiators. PMID: 26209275
    23. lipoxin A4 and PAF are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PMID: 24671173
    24. Osteoblast dysfunctions in DeltaF508-CFTR mice result from altered NF-kappaB and Wnt/beta-catenin signaling. PMID: 26060255
    25. CFTR and BECN1 function can be restored with cysteamine and EGCG in a model of the F508del-CFTR mutation PMID: 25350163
    26. The data of this study strengthen the notion that microvillar cells in the OE play a key role in maintaining tissue homeostasis and identify several mechanisms underlying this regulation through the multiple functions of CFTR. PMID: 25271146
    27. we have shown that DeltaF508cftr-/- mice with defective CFTR exhibit delayed wound healing as compared to wild type mice, indicating that normal function of CFTR is critical for wound repair PMID: 25641604
    28. CFTR and sphingolipids have roles in mediating hypoxic pulmonary vasoconstriction PMID: 25829545
    29. The CFTR-F508del mutation decreases aortic contractility and lowers arterial pressures. PMID: 24801204
    30. the pulmonary phenotype of Cftr(tm1Eur) mice includes airway hyperresponsiveness in the absence of overt lung inflammation or airway remodeling. PMID: 24373976
    31. Increased CFTR expression and decreased ENaC-alpha expression in the decidua of early abortion may relate with failure of early pregnancy. PMID: 24914548
    32. study provides evidence that reversal of CFTR-dependent chloride transport in osteoblasts normalizes bone mass and microarchitecture in murine cystic fibrosis PMID: 24529904
    33. meprin beta is able to cleave the MUC2 mucin N terminus in a process controlled by bacteria and a functional CFTR channel PMID: 25114233
    34. The both wt- and F508del-CFTR (in higher yields with the latter) BAG-1 associates with through its Ub-LD and independently of Hsc70. PMID: 23178238
    35. The results show in vivo a primary role for VIP chronic exposure in CFTR membrane stability and function and confirm in vitro data. PMID: 24898584
    36. CFTR dysfunction triggers epithelial synthesis of VEGF-A, which may contribute to vascular remodelling PMID: 23520314
    37. Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease. PMID: 24236172
    38. Phosphorylation of CFTR at Thr1471 by CK2 correlates with decreased stability of the protein. PMID: 24058532
    39. CFTR activation by roflumilast also induced CFTR-dependent fluid secretion in murine intestine, increasing the wet:dry ratio and the diameter of ligated murine segments. PMID: 24106801
    40. Data indicate that F508del-CFTR mutation is associated with exaggerated airway inflammatory and fibroproliferative repair processes that can be prevented by treatment with vardenafil. PMID: 23734196
    41. after intestinal transplantation, the function of CFTR was impaired, and its mRNA and protein expressions were down-regulated, which may be induced by TNFalpha. PMID: 23626828
    42. We hypothesized that sensitization/challenge of CFTR(-/-) mice with an Aspergillus fumigatus (Af) extract will affect eicosanoid pathway gene expression, impacting Allergic bronchopulmonary aspergillosis and cystic fibrosis PMID: 22985691
    43. CFTR-mediated Cl(-) secretion is therefore an important host determinant of disease, and CFTR inhibition may be of therapeutic benefit in influenza. PMID: 23749967
    44. Alveolar Cl(-) and fluid secretion are triggered by ENaC inhibition and mediated by NKCC and CFTR. PMID: 23645634
    45. Activation of endogenous myocardial CFTR upon early reperfusion is involved in protection against necrotic myocardial injury induced by ischemia/reperfusion in vivo and in vitro. PMID: 23221371
    46. These results suggest that chronic cigarette smoking up-regulates miR-101 and that this miRNA could contribute to suppression of CFTR in the lungs of chronic obstructive pulmonary disease patients. PMID: 23226399
    47. Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways. PMID: 23377346
    48. Low levels of F508del membrane expression in the intestine of CFTR mutant F508del mice significantly increased forskolin-induced HCO(3)(-) secretion mediated by Cl(-)/HCO(3)(-) exchange PMID: 22802588
    49. Keratin 18 increases CFTR expression by binding to its C-terminal hydrophobic domain. PMID: 23045527
    50. A critical role of CFTR in signal transduction linking the environmental HCO(3)(-) to activation of miR-125b during preimplantation embryo development. PMID: 22664907

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  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, CFTR transporter (TC 3.A.1.202) subfamily
  • 组织特异性：
    Expressed in the epididymis (at protein level). In the initial segment of the epididymis, detected on both the luminal and basolateral sides of the ducts where it is expressed in the duct columnar cells as well as in the interstitial smooth muscle cells.
  • 数据库链接：

    KEGG: mmu:12638

    STRING: 10090.ENSMUSP00000049228

    UniGene: Mm.15621

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