Recombinant Mouse Cystine/glutamate transporter (Slc7a11), partial

1. In mouse brain parenchyma, xCT is selectively expressed in scattered astrocytes throughout the brain. Especially strong xCT labeling is found in select blood/brain/CSF interface areas: in the leptomeninges, along larger blood vessels, in some circumventricular organs and in tanycytes in parts of the walls of the ventral third ventricle. Study did not find expression of xCT in microglia, oligodendrocytes and neurons. PMID: 29350434
2. System xC(-)-mediated TrkA activation therefore presents a promising target for therapeutic intervention in cancer pain treatment. PMID: 29761734
3. Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb) through TLR2/Akt- and p38-dependent signaling pathway. PMID: 27129162
4. Protein expression of xCT is enhanced in immune cells from an animal model of multiple sclerosis. PMID: 28086920
5. Study suggests that mature astrocytes have low expression levels of xCT and that they do not depend on its function to survive. In contrast, oligodendrocytes, which express high levels of xCT, are the most vulnerable cell type of CNS to glutathione depletion upon chronic blockage of xCT or under oxidative glutamate toxicity. PMID: 27247047
6. ARF inhibits tumor growth by suppressing the ability of NRF2 to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate antiporter that regulates reactive oxygen species (ROS)-induced ferroptosis. PMID: 28985506
7. Expression of xCT is reduced in astroglia in a genetic mouse model of susceptibility to depressive-like behavior. PMID: 29024663
8. Data suggest that glucose starvation of various neoplasm cell lines induces Slc7a11 expression; Slc7a11 overexpression decreases intracellular glutamate, an alternative source of metabolic energy; provision of alpha-ketoglutarate, a key downstream metabolite of glutamate, restores survival in Slc7a11-overexpressing neoplasm cell lines under glucose starvation. PMID: 28630042
9. HIF-1alpha plays a role in cerebral ischaemia-reperfusion -induced glutamate excitotoxicity via the long-lasting activation of system xc(-) -dependent glutamate outflow PMID: 27801527
10. Results provided important insights into understanding the mechanism associated with xCT deficiency. PMID: 27080807
11. Protein expression of xCT was observed throughout the forebrain and amygdala. PMID: 26494316
12. Cerebellar astroglia isolated from Atm mutant mice show decreased expression of the cystine/glutamate exchanger subunit xCT, glutathione reductase, and glutathione-S-transferase PMID: 26469940
13. IL-1beta increases the level of mRNA encoding xCT in primary cultures of astrocytes isolated from mouse cortex. PMID: 26601945
14. Study found that aglycemic neuronal cell death does not result from changes in astrocyte system xc- expression or activity or from impairment of glutamate removal PMID: 26553727
15. This study indicated that, under physiological conditions, nonvesicular glutamate release via system xc- mediates aspects of higher brain function related to anxiety and depression, but does not influence sensorimotor function or spatial vision PMID: 25619129
16. The study supports a novel role for the Slc7a11 in mediating T cell infiltration into the CNS as well as promoting myelin destruction after immune cell infiltration in experimental autoimmune encephalomyelitis. PMID: 26071560
17. This study demonistrated that System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. PMID: 25384799
18. glutamate released by the cystine/glutamate antiporter activated extrasynaptic, but not synaptic, NMDARs, and blockade of extrasynaptic NMDARs reduced ischemia-gated currents and cell damage after oxygen and glucose deprivation PMID: 25036707
19. In xCT knock-out mice, synapses showed increased spontaneous and evoked synaptic transmission. PMID: 25429150
20. mutant mice of slc7a11 demonstrate deficits in four-arm and three-arm spontaneous alternation tasks, and glutamate level increase in striatium. PMID: 24548853
21. xCT contributes to the maintenance of glutathione levels in lungs and the glutathione redox state as a protective system during oxidative stress. PMID: 23085521
22. CD44v was expressed de novo in spasmolytic polypeptide-expressing metaplasia in mouse models of gastric carcinogenesis, & CD44v(+) metaplastic cells manifested upregulation of xCT expression compared with CD44v(-) cells. PMID: 23848514
23. inhibition of the DNA binding activity of transcriptional repressor OCT-1 is a mechanism by which ethanol up-regulates Slc711 expression. PMID: 23592778
24. Data indicate that ATF4 has a central role in regulating xCT expression and resistance against oxidative stress. PMID: 22095285
25. xCT plays a role in the modulation of hippocampal long-term plasticity. PMID: 22394266
26. under the conditions of glucose deprivation, our studies demonstrate that astrocytes, via system xc-, have a direct, non-cell autonomous effect on cortical neuron survival. PMID: 22220511
27. These data provide the first evidence of hypoxic regulation of the cystine glutamate exchanger system Xc-. PMID: 22056639
28. The cystine/Glu antiporter xCT plays a pivotal role in cellular differentiation through a mechanismrelated to the regulation of transactivation of Runx2 essential for osteoblastogenesis toward maturation in osteoblastic cells. PMID: 21302293
29. results suggest that Runx2 expression would be negatively regulated by xCT expressed by osteoblastic cells at the level of gene transactivation PMID: 21325781
30. System x(c)(-) is required for optimal spatial working memory, but its inactivation is clearly beneficial to decrease susceptibility for limbic epileptic seizures PMID: 21490221
31. loss of functional system xc-, and thus loss of glutamate release via system xc-, results in significantly decreased striatal extracellular glutamate and is accompanied by significant neuroprotection of dopaminergic neurons in SNc against 6-OHDA toxicity. PMID: 21191088
32. Data show that ablation of CD44 induced loss of xCT from the cell surface and suppressed tumor growth in a mouse model of gastric cancer. PMID: 21397861
33. These results suggest that Glu may play a role as a negative regulator at an early differentiation stage into osteoblasts than adipocytes by the cystine/Glu antiporter expressed in mesenchymal stem cells. PMID: 20717926
34. Review discusses system xc- function in vitro and in vivo, its role as an ambivalent drug target, and the relevance of oxytosis mediated by inhibition of xCT for identification of neuroprotective proteins and signlaing pathways. PMID: 20053169
35. Forced expression of xCT, the substrate-specific subunit of the cystine/glutamate antiporter, in gamma-glutamylcysteine synthetase knock-out cells rescues glutathione deficiency. PMID: 20463017
36. showed that xCT, a component of transport system x(c)(-), was significantly up-regulated in activated infiltrating cells, including macrophages and neutrophils at the inflammatory site. PMID: 20308543
37. Data show that the xCT subunit of the cystine/glutamate exchange transporter is strongly induced by diethyl maleate in BHK21 cells and contains several EpRE-like sequences. PMID: 12235164
38. Results demonstrate that xCT is a new member of the proteins whose transcriptional control by the amino acid deprivation is mediated by the amino acid response element. PMID: 15522208
39. Slc7a11 is a major genetic regulator of pheomelanin pigment in hair and melanocytes. Transport of cystine by xCT is critical for normal proliferation, glutathione production, and protection from oxidative stress in cultured cells. PMID: 16037214
40. The generation and characterization of cysteine-glutamate transporter deficient mice is reported. PMID: 16144837
41. These results suggest that inhibition of microglial system Xc- might be of therapeutic value in the treatment of AD. Its inhibition not only prevents glutamate excitotoxicity but also facilitates neuroprotection by apoE. PMID: 16554485
42. These results suggest that system xc- plays an important role in neutrophils when they are activated, and their GSH consumption is accelerated. PMID: 17200146
43. These results demonstrate that xCT expression plays a role in regulating cellular proliferation in the DG, but not the SVZ of adult mice. PMID: 17963724
44. Data show that xCT of EL mice at 10 weeks of age decreased more than those of DDY. PMID: 18621028
45. Caveolin-1 was upregulated and beta-catenin was recruited to the plasma membrane when xCT was deficient, which were followed by the inhibition of beta-catenin transcriptional activity. PMID: 19015640
46. long term activation of the phospho-eIF2alpha/ATF4/xCT signaling module by the specific eIF2alpha phosphatase inhibitor, salubrinal, induces resistance against oxidative glutamate toxicity in the hippocampal cell line HT22 and primary cortical neurons PMID: 19017641
47. Oxidative stress and mGluR5 activation induced by BMAA are both mediated through action at system Xc(-). The multiple mechanisms of BMAA toxicity may account for its ability to induce complex neurodegenerative diseases. PMID: 19374900
48. T cell expression is induced following burn injury PMID: 19576933
49. Aggravation of ischemia-reperfusion-triggered acute renal failue in xCT-deficient mice is reported. PMID: 19695216
50. One of the genes up-regulated in Hfe-/- RPE cells was Slc7a11 (where Slc is solute carrier) which codes for the 'transporter proper' xCT in the heterodimeric cystine/glutamate exchanger (xCT/4F2hc). PMID: 19715555

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KEGG: mmu:26570

STRING: 10090.ENSMUSP00000029297

UniGene: Mm.260988