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  4. Recombinant Mouse Disks large-associated protein 1 (Dlgap1), partial

Recombinant Mouse Disks large-associated protein 1 (Dlgap1), partial

  • 中文名称：
    小鼠Dlgap1重组蛋白
  • 货号：
    CSB-YP887517MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dlgap1重组蛋白
  • 货号：
    CSB-EP887517MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dlgap1重组蛋白
  • 货号：
    CSB-EP887517MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dlgap1重组蛋白
  • 货号：
    CSB-BP887517MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dlgap1重组蛋白
  • 货号：
    CSB-MP887517MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dlgap1
  • Uniprot No.：
    Q9D415
  • 别名：
    Dlgap1; Gkap; Kiaa4162Disks large-associated protein 1; DAP-1; Guanylate kinase-associated protein; PSD-95/SAP90-binding protein 1; SAP90/PSD-95-associated protein 1; SAPAP1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Part of the postsynaptic scaffold in neuronal cells.
  • 基因功能参考文献：
    1. These data suggest that Dlgap1 knockout leads to post-synaptic density disruption and reduced sociability, consistent with reports of DLGAP1 haploinsufficient variants in schizophrenia and autism spectrum disorder. PMID: 29396406
    2. Expression of Dlgap1 in the mouse prefrontal cortex is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase). PMID: 20808911
    3. the loss of the SH3, protein 4.1 and/or GUK domains of Dlg1 disrupt epithelial polarity and perturb nephrogenesis either as a secondary consequence to a defect in ureteric branching morphogenesis and/or delay in mesenchyme-to- epithelial transition PMID: 16105026
    4. results suggest that inactivation of Dlg1 augments HTLV-1 Tax-mediated transformation of the T-cell line (CTLL-2) PMID: 17042961
    5. Semi-quantitative analysis of RNA levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components, such as Shank1, SAPAP1-3, PSD-95, and the glutamate receptor subunits NR1 and NR2B, are associated with FMRP. PMID: 19640847

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族：
    SAPAP family
  • 组织特异性：
    Highest levels in the neocortex, part of the hippocampus, the granule cell layer of the cerebellum, the glomerular layer of the olfactory bulb, the inner plexiform layer of the retina, the ventral and dorsal horn of the spinal chord, the neuromuscular jun
  • 数据库链接：

    KEGG: mmu:224997

    STRING: 10090.ENSMUSP00000122896

    UniGene: Mm.311840

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