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  4. Recombinant Mouse Ezrin (Ezr)

Recombinant Mouse Ezrin (Ezr)

  • 中文名称：
    小鼠Ezr重组蛋白
  • 货号：
    CSB-YP007914MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ezr重组蛋白
  • 货号：
    CSB-EP007914MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ezr重组蛋白
  • 货号：
    CSB-EP007914MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ezr重组蛋白
  • 货号：
    CSB-BP007914MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ezr重组蛋白
  • 货号：
    CSB-MP007914MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ezr
  • Uniprot No.：
    P26040
  • 别名：
    Ezr; Vil2Ezrin; Cytovillin; Villin-2; p81
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-586
  • 氨基酸序列
    PKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLQYV DNKGFPTWLK LDKKVSAQEV RKENPVQFKF RAKFYPEDVA EELIQDITQK LFFLQVKDGI LSDEIYCPPE TAVLLGSYAV QAKFGDYNKE MHKSGYLSSE RLIPQRVMDQ HKLSRDQWED RIQVWHAEHR GMLKDSAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM LREKEELMLR LQDYEQKTKR AEKELSEQIE KALQLEEERR RAQEEAERLE ADRMAALRAK EELERQAQDQ IKSQEQLAAE LAEYTAKIAL LEEARRRKED EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP VNYHVQEGLQ DEGAEPMGYS AELSSEGILD DRNEEKRITE AEKNERVQRQ LLTLSNELSQ ARDENKRTHN DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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Ezr ELISA kits

靶点详情

  • 功能：
    Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
  • 基因功能参考文献：
    1. Ezrin level may serve as a differential diagnostic and/or prognostic biomarker for high and low lymphatic metastasis -Hepatocellular carcinoma (HCC)and may be beneficial in the diagnosis of HCC disease PMID: 28608644
    2. Inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin proteins and increased Rho-GTP. PMID: 28302370
    3. high actin-ezrin intensity area restricts the lateral movement of B cell receptors upon stimulation, reducing receptor clustering and signaling PMID: 28821013
    4. Ezrin may play a role in regulating lymphatic metastasis in hepatocellular carcinoma and might be inversely associated with A7 expression. PMID: 27914826
    5. Augmented hypertension-induced glomerular capillary injury in mice lacking CLIC5 results from abrogation of Rac1-dependent Pak and ezrin activation, perhaps reducing the tensile strength of the podocyte actin cytoskeleton. PMID: 26924049
    6. Data, including data from studies in knockout mice, suggest that VDR (vitamin D receptor) regulates expression of ezrin in enterocytes; VDR appears not to be involved in morphology of tight junctions and absorption of large molecules in enterocytes. PMID: 26606857
    7. Lack of ezrin not only causes achlorhydria and hypergastrinemia but also changes the structure of gastric glands, with severe perturbation of the secretory membranes of parietal cells. PMID: 26329936
    8. our study demonstrates that ezrin is a novel regulator of IL-10 production by B cells PMID: 26673134
    9. Merlin and Ezrin are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor. PMID: 26483553
    10. Dysfunction of ezrin mimics important aspects of the pathological mechanisms responsible for cholangiopathies PMID: 25311759
    11. We hypothesize that polyvalent electrostatic interactions are responsible for the assembly of CD44 clusters and the multimeric PIP2-CD44-Ezrin complexes. PMID: 25572402
    12. These results indicate that ezrin is required for uptake of hypotaurine from maternal serum by placental trophoblasts, and plays an important role in fetal growth. PMID: 25144766
    13. These data altogether suggest a novel role of ezrin in the neuritogenesis of the cultured cortical neurons through down-regulation of RhoA activity. PMID: 25144196
    14. Beta-dystroglycan can respond to ezrin driven cytoskeletal and cell morphology changes,by translocating from the cytoplasm to the nucleus. PMID: 24599031
    15. The findings demonstrate that adult neural stem cells and neuroblasts express ezrin and that ezrin may be involved in intracellular actin remodeling. PMID: 23229862
    16. ALCAM stably interacts with actin by binding to syntenin-1 and ezrin. PMID: 24662291
    17. Ezrin binds to and is dephosphorylated by PTPsigma in vitro, suggesting it is a direct PTPsigma substrate. PMID: 24385580
    18. Data indicate that Crb3 (Crumbs3) is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin-containing cytoskeleton. PMID: 24164893
    19. ezrin regulates amplification of b-cell receptor signals and tunes the strength of B cell activation and humoral immunity. PMID: 24043890
    20. Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organs. PMID: 23468835
    21. Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. PMID: 23017497
    22. Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis. PMID: 22895514
    23. during 8-cell embryocompaction Rho GTPases facilitate the apical distribution of aPKC and Ezrin; aPKC and Mek/Erk work together to promote Ezrin phosphorylation at the apical region; data also suggested that aPKC might be the Ezrin kinase during eight-cell embryo compaction PMID: 23313818
    24. Ezrin has a novel role as a spatial adaptor that couples JNK signaling components to the BCR signalosome, thus facilitating JNK activation. PMID: 23338238
    25. A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells. PMID: 23063725
    26. the extracellular matrix molecule VN and its neuronal receptor TLCN play a pivotal role in the phosphorylation of ezrin/radixin/moesin proteins and the formation of phagocytic cup-like structures on neuronal dendrites PMID: 23019340
    27. Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein. PMID: 22891241
    28. our results suggest that dynamic regulation of Ezrin phosphorylation at amino acid T567 that controls structural transitions of this protein plays a pivotal role in tumor progression and metastasis, possibly in part by altering cellular metabolism. PMID: 22147261
    29. The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers. PMID: 22132106
    30. Ezrin-radixin-moesin (ERM) proteins are induced in activated microglia/macrophages, whereas ERM molecules are only marginally expressed in quiescent microglia in the normal brain. PMID: 21451358
    31. Ezrin is key regulator of Src-induced malignant phenotype in three-dimensional environment. PMID: 21666723
    32. Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability. PMID: 21659656
    33. Dbl is regulated by hamartin through association with ezrin. PMID: 21712385
    34. The function of Ezrin in building and maintaining the apical domain is essential not only for intestinal morphogenesis but also for homeostasis in the mature intestine. PMID: 21730140
    35. deletion of ezrin results in defects in mouse intestinal villus morphogenesis. (Review) PMID: 21343695
    36. Transient dephosphorylation of ezrin regulates membrane flexibility that the B cell must achieve during migration, followed by relocalization to the actin-rich lamellipodia for dynamic forward protrusion of the cells. PMID: 21339367
    37. Data suggest that myosin-II and ERM proteins modulate mechanical properties in oocytes, contributing to cell polarity and to completion of meiosis. PMID: 20660156
    38. ezrin is dispensable for lymphoid development PMID: 20806059
    39. CLIC5A colocalizes with ezrin and podocalyxin in podocytes and is required for the development/maintenance of the proper glomerular endothelial cell and podocyte architecture. PMID: 20335315
    40. Data show that ezrin associates with Hsc70 that locates on the membrane of TG cells and participates in the bacterial uptake by TG cells. PMID: 19737422
    41. Ezrin and EBP50 interact with high affinity; disruption of this complex interfered with cAMP modulation of T-cell activation PMID: 19857202
    42. Results suggest that if mutations that contribute to polycystic kidney disease pathogenesis might disrupt normal tubular development, the mechanism may include altered ezrin function and abnormal protein kinase A targeting. PMID: 12840161
    43. cross talk between the blastocyst and uterus involving the ezrin/radixin/moesin (ERM) proteins and ERM-associated cytoskeletal cross-linker proteins CD43, CD44, ICAM-1, and ICAM-2 PMID: 14613898
    44. Data show that ezrin and the homeodomain-containing transcription factor Six-1 (sine oculis-related homeobox-1 homolog) had essential roles in determining the metastatic fate of rhabdomyosarcoma cells. PMID: 14704789
    45. in a mouse model of osteosarcoma ezrin was found to be necessary for metastasis; results showed that ezrin expression provided an early survival advantage for cancer cells that reached the lung PMID: 14704791
    46. Ezrin organizes the apical terminal web region of intestinal epithelium, which is critical the process of de novo lumen formation and expansion during villus morphogenesis. PMID: 15177033
    47. Ezrin gene, coding for a membrane-cytoskeleton linker protein, is regionally expressed in the developing mouse neuroepithelium PMID: 15465499
    48. Adult Vil2(kd/kd) mice suffered from severe achlorhydria. PMID: 15809309
    49. ezrin is required for breast cancer metastasis PMID: 15987432
    50. ezrin and beta-catenin are both present at the cell membrane of the glial tube cells suggests that these proteins may be involved in those signaling processes. PMID: 16996217

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  • 亚细胞定位：
    Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, microvillus.
  • 组织特异性：
    Detected in eye lens fiber cells. Expressed in cerebrum and cerebellum (at protein level). Component of the microvilli of intestinal epithelial cells.
  • 数据库链接：

    KEGG: mmu:22350

    STRING: 10090.ENSMUSP00000063734

    UniGene: Mm.277812

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