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  4. Recombinant Mouse General transcription factor II-I repeat domain-containing protein 1 (Gtf2ird1), partial

Recombinant Mouse General transcription factor II-I repeat domain-containing protein 1 (Gtf2ird1), partial

  • 中文名称：
    小鼠Gtf2ird1重组蛋白
  • 货号：
    CSB-YP888303MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gtf2ird1重组蛋白
  • 货号：
    CSB-EP888303MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gtf2ird1重组蛋白
  • 货号：
    CSB-EP888303MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gtf2ird1重组蛋白
  • 货号：
    CSB-BP888303MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gtf2ird1重组蛋白
  • 货号：
    CSB-MP888303MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gtf2ird1
  • Uniprot No.：
    Q9JI57
  • 别名：
    Gtf2ird1; Ben; General transcription factor II-I repeat domain-containing protein 1; GTF2I repeat domain-containing protein 1; Binding factor for early enhancer
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8.
  • 基因功能参考文献：
    1. The mis-regulation of genes downstream of GTF2IRD1, including TbetaR2 and BMPR1b, also individually promoted mammary cancer development, and silencing of TbetaR2 suppressed GTF2IRD1-driven tumor promotion. PMID: 27239038
    2. the absence of GTF2IRD1 is associated with increased expression of genes involved in cellular proliferation, including growth factors consistent with the observed phenotype of extreme thickening of the epidermis. PMID: 27295951
    3. Gtf2ird1 is essential for Mkx transcription, while also linking mechanical forces to Mkx-mediated tendon homeostasis and regeneration. PMID: 26884464
    4. Gtf2ird1 is expressed in a number of cell types within the cochlea. Gtf2ird1 null mice showed higher auditory thresholds. PMID: 25248400
    5. findings suggest an important role for GTF2IRD1 in regulating the level and topology of rod and cone gene expression, and in maintaining normal retinal function. PMID: 25392503
    6. GTF2IRD2 has evolved as a regulator of GTF2IRD1 and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones. PMID: 22899722
    7. This study presented that role for GTF2IRD1 in the motoric and anxiety-related abnormalities seen in Williams-Beuren syndrome, and suggests basal ganglia and potentially cerebellar abnormalities in Gtf2ird1 mice. PMID: 22652393
    8. Widespread and robust expression of Gtf2ird1 protein in the developing rodent brain, is reported. PMID: 21909369
    9. Data show the existence of a negative autoregulatory mechanism that controls the level of GTF2IRD1 transcription via direct binding of the GTF2IRD1 protein to a highly conserved region of the GTF2IRD1 promoter containing an array of three binding sites. PMID: 20007321
    10. The presence of different domains in 11 alternatively spliced isoforms of Gtf2ird1 indicates that the activity exerted by this molecule influences multiple promoters active in mouse skeletal muscle. PMID: 12780350
    11. TFII-I (Mus-TRD1) has a role in regulating immunoglobulin promoter activity PMID: 14645227
    12. First systematic and unbiased analysis of individual GTF2I-like repeats with regard to DNA binding PMID: 15987678
    13. GTF2IRD1 is a genetic determinant of mammalian craniofacial and cognitive development PMID: 16293761
    14. During development, a dynamic pattern of GTF2IRD1 expression is found predominantly in musculoskeletal tissues, the pituitary, craniofacial tissues, the eyes and tooth buds. PMID: 17239664
    15. GTF2IRD1 knockout mice showed a reduced size of the corpus callosum PMID: 17270452
    16. These transcription factors may influence fear and social behavior through the alteration of neurochemical pathways PMID: 17680805
    17. expression of TFII-I gene family were mapped in embryonic tooth germs; at bud stage, Gtf2ird1 & Gtf2ird2 were expressed in epithelial buds; at early bell stage, expression of Gtf2ird1 & Gtf2ird2 was observed in preameloblasts & preodontoblasts PMID: 17823943
    18. analysis of the consensus binding site for TFII-I family member BEN PMID: 18326499
    19. homozygous loss of Gtf2ird1 or Gtf2i results in multiple phenotypic manifestations, including embryonic lethality; brain hemorrhage; and vasculogenic, craniofacial, and neural tube defects; defects in yolk sac vasculogenesis and angiogenesis PMID: 19109438

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TFII-I family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:57080

    STRING: 10090.ENSMUSP00000098217

    UniGene: Mm.332735

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