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  4. Recombinant Mouse Guanine nucleotide exchange factor VAV2 (Vav2), partial

Recombinant Mouse Guanine nucleotide exchange factor VAV2 (Vav2), partial

  • 中文名称：
    小鼠Vav2重组蛋白
  • 货号：
    CSB-YP730676MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Vav2重组蛋白
  • 货号：
    CSB-EP730676MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Vav2重组蛋白
  • 货号：
    CSB-EP730676MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Vav2重组蛋白
  • 货号：
    CSB-BP730676MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Vav2重组蛋白
  • 货号：
    CSB-MP730676MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Vav2
  • Uniprot No.：
    Q60992
  • 别名：
    Vav2; Guanine nucleotide exchange factor VAV2; VAV-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
  • 基因功能参考文献：
    1. reduction of VAV2 in absence of CUX1 was associated with a significant decrease of RAC1 activity in response to epithelial wounding. Our results identify a novel pathway by which CUX1 regulates normal intestinal epithelial cell restitution PMID: 28893557
    2. This inhibitory action of Vav2 shRNA on Hcys-induced podocyte injury was associated with reduction of Rac1 activity and ROS production. These results suggest that elevated Hcys levels activate Vav2 and thereby increase NOX activity leading to ROS production, which triggers NLRP3 inflammasome activation, podocyte dysfunction and glomerular injury. PMID: 28193546
    3. Results show that Vav2 and Rac1 are commonly involved in blood pressure regulation. PMID: 25288640
    4. Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 is critical for the development of this tumor type. PMID: 23935450
    5. Vav2 and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery. PMID: 22596354
    6. The results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac. PMID: 22027834
    7. Cbl ubiquitin ligase plays a critical role in the maintenance of AJs and suppression of cell migration through down-regulation of EGFR-Vav2 signaling. PMID: 20940296
    8. Data show that Vav2/Vav3-deficient mice show early onset of iridocorneal angle changes and elevated intraocular pressure, with subsequent selective loss of retinal ganglion cells and optic nerve head cupping, which are the hallmarks of glaucoma. PMID: 20140222
    9. Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. PMID: 20038798
    10. does not contribute to platelet aggregation by CRP and thrombin, and is not required for regulation of phospholipase C. PMID: 12411320
    11. Vav2 is a GEF responsible for the nectin-induced, c-Src-, and Cdc42-mediated activation of Rac PMID: 15485841
    12. Vav2-deficient macrophages display a high level of constitutive membrane ruffling. PMID: 16137676
    13. These results indicate that Vav2 plays crucial roles in the maintenance of cardiovascular homeostasis in mice. PMID: 17202406
    14. Vav2 regulates the Rac1 activity associated with the binding step of collagen phagocytosis. PMID: 18434624
    15. Data suggest that Vav2/3 guanine nucleotide exchange factors play a critical role in host-mediated tumor progression and angiogenesis, particularly in tumor endothelium. PMID: 19435813

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  • 数据库链接：

    KEGG: mmu:22325

    STRING: 10090.ENSMUSP00000062782

    UniGene: Mm.179011

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