Recombinant Mouse Insulin receptor substrate 1 (Irs1), partial

1. DPP-4 inhibitor sitagliptin has effects on cardiac function, glycemia, and beta-cell function together with reducing S6K1 activation and IRS-1 and IRS-2 degradation in the obesity female mouse model PMID: 30116740
2. 'selective insulin resistance' is caused by the differential expression of Irs1 and Irs2 in different zones of the liver PMID: 27708333
3. Lung-specific dual ablation of insulin receptor substrates 1/2 (succumb to tumor burdenIrs1/Irs2) strongly suppresses tumor initiation and dramatically extends the survival of a mouse model of lung cancer with Kras activation and p53 loss. Mice with Irs1/Irs2 loss eventually. PMID: 29610318
4. Noise exposure led to enhanced JNK phosphorylation and IRS1 serine phosphorylation as well as reduced Akt phosphorylation in skeletal muscles in response to exogenous insulin stimulation. PMID: 29433422
5. The data, therefore, suggest that 1,25(OH)2D3 increases glucose consumption by inducing SIRT1 activation, which in turn increases IRS1 phosphorylation and GLUT4 translocation in myotubes. PMID: 29188534
6. Results show that lack of IRS1 prevents beta-cell apoptosis induced by ER stress, and promotes XBP-1 instability secondary to proteasomal degradation. PMID: 27378176
7. Using two long-lived IIS models, namely Drosophila lacking three insulin-like peptides (dilp2-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms PMID: 27452396
8. findings suggest that up-regulation of miR-222 followed by reduction in IRS-1 expression may be a viable mechanism of insulin resistance in the liver PMID: 29364977
9. These results demonstrate the cooperative interaction between RPTPbeta and the IGF-I receptor leading to a coordinated series of signaling events that are required for osteoblast differentiation. Our findings emphasize the important role IRS-1 plays in modulating these signaling events and confirm its essential role in facilitating osteoblast differentiation PMID: 26773517
10. EGCG significantly ameliorated insulin resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1)/AKT and ERK/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathways. PMID: 28739640
11. Pit1 deletion inhibited USP7/IRS1 dissociation upon insulin stimulation. PMID: 27568561
12. TSH improves insulin sensitivity in skeletal muscle by increasing Irs1 gene expression. PMID: 27452800
13. Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR-342 PMID: 27623927
14. Irs1 was downregulated in the arcuate nucleus of type 2 diabetic mice. PMID: 28456145
15. These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation PMID: 28003360
16. Decreased miR-33 levels can up-regulate IRS-2 expression, which appears to compensate for the defects of the insulin signaling pathway in Irs-1 deficient mice. PMID: 28190325
17. Concentration of SOCS-3 protein and coimmunoprecipitation of SOCS-3 protein with both the IR-beta subunit as well as IRS-1 was found to be decreased by 4-HIL PMID: 26887316
18. Authors propose that insulin/IGF-1 cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf longevity phenotype. PMID: 26474286
19. within the hepatic compartment, mTORC1 --> S6K signaling regulates Akt largely through IRS-independent means with little effect upon physiologic insulin sensitivity. PMID: 26846849
20. Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC development and progression. PMID: 26433160
21. Insulin receptor substrate-1-mediated insulin signal transduction may be an important factor in the treatment of cognitive decline induced by insulin resistance. PMID: 26047734
22. Full Length Irs-1 transcript functions as a bifunctional RNA during myogenic differentiation. PMID: 25887310
23. melatonin can ameliorate insulin sensitivity by inhibiting Ser307 phosphorylation in IRS-1 PMID: 24846082
24. Most importantly, treatment of cells with the RhoA/ROCK inhibitor, Y-27632, which among its many effects also inhibited serine 636 phosphorylation of IRS-1, had profound effects on cell-substratum adhesion PMID: 24470116
25. Results indicate that although IRS isoforms (irs1 and irs2) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise. PMID: 25002528
26. precise regulation of IRS-1 expression level is critical for determining the differentiating capacity of mouse mesenchymal stem cells and osteosarcoma cells, and that derangement of IRS-1 levels can be a critical step in osteosarcoma transformation. PMID: 24438070
27. ectopic expression of miR-29a impairs insulin signaling and glucose uptake in myocytes through a substantial decrease in IRS-1 PMID: 24844433
28. PKCtheta regulates myogenic and protein synthetic signaling via the modulation of IRS1 and ERK1/ERK2 phosphorylation. PMID: 24053798
29. increased neuronal IRS2 signaling causes decreased locomotoric activity in the presence of unaltered exploratory behavior and motor coordination that might lead to increased fat mass, insulin resistance, and glucose intolerance during aging PMID: 23160735
30. MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H. PMID: 23965929
31. Our results demonstrate that blockade of IRS1(Ser307) phosphorylation in vivo does not prevent mTORC1-mediated glucose intolerance and insulin resistance. PMID: 24333417
32. Mice with combined cardiomyocyte-specific deletion of Irs1 & Irs2 had unrestrained autophagy in cardiomyocytes, leading to myocyte loss, heart failure, premature death, apoptosis & mitochondrial dysfunction. PMID: 24177427
33. Data indicate a reduction of IRS-1pS636 (serine phosphorylation at 636) level accompanied with decreased Abeta42 levels in the hippocampus of APP/PS1 transgenic mice after treatment with epigallocatechin-3-gallate (EGCG). PMID: 23660953
34. Taken together, our findings demonstrate that activation of the ERK pathway in sensory neurons as a consequence of mTORC1 inhibition leads to the development of pain. PMID: 23607966
35. The increase in insulin-induced adipogenesis by beta-arrestin knock-down was concomitant to a decrease in the insulin receptor susbtrate-1 serine phosphorylation, proving the loss of the negative feedback loop on IRS-1/phosphoinositide 3-kinase/Akt. PMID: 23557604
36. findings reveal that, in addition to persistent mTORC1 signalling, increased mTORC2 signals can promote insulin resistance due to mTORC2-mediated degradation of IRS-1 PMID: 23863152
37. Data indicate the association of Par14 with insulin receptor substrate 1 (IRS-1) in human HepG2 cells overexpressing both as well as endogenously in the mouse liver. PMID: 23720771
38. Data from knockout mice and cocultured hepatocytes/sinusoidal endothelial cells suggest that up-regulation (not down-regulation) of insulin/insulin receptor/Irs1 signaling in liver sinusoidal endothelium leads mice to insulin resistance. PMID: 23349480
39. Impairment of insulin-induced glucose uptake into damaged muscle after strenuous exercise would be related to disturbance of insulin signal transduction by oxidative modification of IRS-1. PMID: 22188104
40. C1-Ten is a novel protein tyrosine phosphatase (PTPase) of IRS-1 that acts as a mediator to reduce IRS-1 under a catabolic condition, resulting in muscle atrophy. C1-Ten preferentially dephosphorylated Y612 of IRS-1, which accelerated IRS-1 degradation. PMID: 23401856
41. IRS-1 inhibition might protect against HF diet-induced NASH and liver tumourigenesis, despite the presence of insulin resistance. PMID: 22955994
42. These results suggest that genipin activates IRS-1, PI3-K, and downstream signaling pathway and increases concentrations of calcium, resulting in GLUT4 translocation and glucose uptake increase in C(2)C(12) myotubes. PMID: 23257267
43. What is the mechanism of serotonin-induced insulin resistance? Data suggest that activation of Akt (proto-oncogene protein c-akt) is involved in reducing adverse effects of serotonin by stabilizing IRS-1 in low density microsomes in adipocytes. PMID: 22975078
44. IRS1 levels are significantly increased in mouse cell lines representing fat and muscle lineages with p/CIP and SRC-1 deletions and in white adipose tissue and skeletal muscle of knockout mice. PMID: 22859932
45. mTORC2 negatively feeds back to IRS-1 via control of Fbw8 stability and localization. PMID: 23142081
46. alpha-LA protects 3T3-L1 adipocytes from LYRM1-induced insulin resistance partially via its capacity to restore mitochondrial function and/or increase phosphorylation of IRS-1 and Akt. PMID: 22820890
47. Our results suggest that overexpression of IRS-1 promotes cells growth, inhibits basal autophagy, reduces oxidative stress-induced autophagy, and diminishes oxidative stress-mediated autophagy-dependent cell death. PMID: 22788551
48. Overexpression of p62 increased phosphorylation of Akt, GLUT4 translocation, and glucose uptake, providing evidence that p62 participates in the insulin-signaling pathway through its interactions with IRS-1. PMID: 22761437
49. The results suggest IRS1 enhances sensitivity to chemotherapy in part through Annexin A2. PMID: 22652453
50. find that both IRS1 and kinase active IGF1R are required for ETV6-NTRK3 transformation, that tyrosine phosphorylated IRS1 is present in high molecular weight complexes with EN and IGF1R, and that EN colocalizes with IGF1R at the plasma membrane PMID: 21804605

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KEGG: mmu:16367

STRING: 10090.ENSMUSP00000063795

UniGene: Mm.4952