Recombinant Mouse Metabotropic glutamate receptor 1 (Grm1), partial

1. Study states that metabotropic glutamate receptor subtype 1 (mGluR1) is critical for elimination of surplus climbing fiber-Purkinje cell synapses in the cerebellum, retinogeniculate synapses require mGluR1 for maintenance of mature connectivity. PMID: 28711710
2. Study shows that blocking of metabotropic glutamate type 5 receptor (mGlu5) reduced the dysregulation of glutamate transmission and improved motor coordination in the metabotropic glutamate type 1 receptor (Grm1crv4) mouse model of cerebellar ataxia SCAR13. PMID: 28982591
3. These findings demonstrate that mGlu1 receptors play a key role in excitotoxic degeneration of retinal ganglion cell PMID: 28918254
4. this work reveals novel functions of mGlu1 receptors in the bone and indicates that in osteoblasts mGlu1 receptors are necessary for production of normal bone matrix, longitudinal bone growth, and normal skeletal development. PMID: 27989650
5. mGluR1 activation at the onset of reperfusion induces cardioprotection and might represent a putative strategy to prevent ischaemia-reperfusion injury. PMID: 28453728
6. These findings demonstrate a deleterious positive feedback loop involving elevated intracellular calcium and enhanced mGluR1 function, a mechanism likely to contribute to Purkinje neuron dysfunction and loss in spinocerebellar ataxia type 2. PMID: 28518055
7. mouse external globus pallidus astrocytes critically control ambient glutamate level, which in turn gates striatopallidal transmission via the activation of presynaptic metabotropic glutamate receptors. PMID: 27880915
8. The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture. PMID: 27998287
9. This study confirmed the presence of mGluR1/5 complex by (i) reverse immunoprecipitation using an mGluR1 antibody to pulldown mGluR5 from hippocampal tissue. PMID: 27392515
10. results demonstrate that mGluR1 is crucial for the visual-experience-dependent maintenance of mature synaptic connectivity in the dorsal Lateral Geniculate Nuc. PMID: 27545713
11. These results suggest that impairment of synaptic mGluR cascades is one of the important contributing factors to cerebellar ataxia in early and middle stages of spinocerebellar ataxia type 1 (SCA1) pathology, and that modulation of mGluR signalling by baclofen or other clinical interventions may be therapeutic targets to treat SCA1 PMID: 27440721
12. activation of mGluR1 expressed by OCCM-30 cells induces cell proliferation in a manner that is dependent on mitogen-activated protein kinase pathways. PMID: 27261070
13. In a mouse model of human spino-cerebellar ataxia type 1 (early SCA1, 12 weeks) we find prolonged parallel fiber mGluR1-dependent synaptic currents and calcium signaling PMID: 27147646
14. Here we identify mGluR1 and mGluR5 as key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the TRN. Our findings highlight potential mechanisms that regulate cholinergic signaling in the mammalian brain. PMID: 27466334
15. data suggest that Lys(63)-linked polyubiquitination is involved in the ligand-mediated endocytosis of mGluR1. PMID: 28011638
16. This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (mGlu) receptor-induced increase in action potential firing. PMID: 28137639
17. Homodimerization enhances both sensitivity and dynamic range of the ligand-binding domain of type 1 metabotropic glutamate receptor PMID: 27800613
18. Unpredictable chronic mild stress mice exhibited elevated nucleus accumbens (NAC) shell levels of mGlu1alpha. The expression of stress-alcohol locomotor cross-sensitization was associated with lower mGlu1alpha within the NAC core. PMID: 25916683
19. Ionizing radiation is able to trigger the altered neuronal differentiation in undifferentiated neural stem-like cells through PI3K-STAT3-mGluR1 and PI3K-p53 signaling. PMID: 26828720
20. Because the mGluR1-PKCgamma signaling pathway is essential for the late-phase of climbing fiber synapse elimination, this signaling pathway promotes the two key features of excitatory synaptic wiring in Purkinje cells. PMID: 26858447
21. Numb is a regulator for constitutive expression and dynamic transport of mGlu1. PMID: 26621723
22. STIM1 is a key regulator of mGluR1-dependent Ca(2+) signaling. PMID: 25304289
23. Selective photostimulation of astrocytes with channelrhodopsin-2 in primary visual cortex enhances both excitatory and inhibitory synaptic transmission, through the activation of type 1a metabotropic glutamate receptors. PMID: 24500276
24. Results provide unequivocal demonstration of the intrasynaptic localization of mGlu1 receptors in GABAergic synapses and confirm their peri-junctional enrichment in glutamatergic synapses PMID: 25377770
25. Activation of mGluR1 facilitates firing of molecular layer interneurons through the TRPC1-mediated inward current, which depends on not only G protein-dependent but also Src-ERK1/2-dependent signaling pathways. PMID: 25181481
26. Homer 1a was neuroprotective against traumatic brain injury in vitro and in vivo, and this neuroprotection was associated with its effects on group I metabotropic glutamate receptors. PMID: 24722299
27. Stimulation of mGluR1 during glutamate exposure mediates prolonged epileptiform discharges in the hippocampus. PMID: 25568123
28. Transcriptome sequencing of melanocytic nevi and melanomas from Grm1 transgenic mice to determine melanoma driver mutations. PMID: 24661573
29. a potential crosstalk network between mGluR1 and tyrosine kinase, insulin-like growth factor 1 receptor (IGF-1R). PMID: 24628914
30. Results suggest a role for mGluR1 in breast cancer as a pro-angiogenic factor as well as a mediator of tumor progression. PMID: 24633367
31. Results indicate that mGlu1 receptor-mediated activation of phospholipase C within the shell subregion of the nucleus accumbens is an intracellular signaling pathway involved in the maintenance of alcohol intake by mice under limited access procedures PMID: 24467847
32. Results demonstrate that a lower constitutive level of mGluR1 has a significant positive impact on mice with experimental ALS, providing a rationale for future pharmacological approaches to ALS by selectively blocking Group I metabotropic Glu receptors PMID: 24361555
33. Binge alcohol drinking increases mGluR1 signaling within the central nucleus of the amygdala. PMID: 23966068
34. activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission PMID: 23558090
35. We conclude that the long C-terminal domain of mGluR1a is required for the proper perisynaptic targeting of mGluR1 and cerebellar function PMID: 24523559
36. The Grm1(crv4) mouse with a spontaneous mutation inactivating the metabotropic glutamate type 1 receptor show overexpression of metabotropic glutamate type 5 receptor and enhanced glutamate release worsening motor-coordination defects in these mice. PMID: 22791805
37. mGluR1 recruitment to lipid rafts is enhanced by agonist binding and is supported at least in part by an intact cholesterol recognition/interaction amino acid consensus (CRAC) motif in the receptor. PMID: 24045944
38. The activation of mGluR1,5 is likely a potential therapeutic strategy to prevent nervous tissues from excitotoxicity by reducing the impairment of the astrocytes and GABAergic neurons during the early stage of ischemia. PMID: 23280324
39. mGluR1,5 activation improves the anxiety-like behaviors of DBA/2 mice. PMID: 22681774
40. Both cytokines as well as cellular immune escape mechanisms seem to contribute to the observed immunosuppressed state of tumor-bearing grm1-transgenic mice. PMID: 22674057
41. Tg(Grm1)EPv melanoma model exhibits more extensive metastasis into distant organs than previously described. Disseminated cells undergo phenotypic changes, as we observed high numbers of non-pigmented Grm1-expressing melanoma cells within distant organs. PMID: 22882420
42. Transient stimulation of mGluR1 alters receptor properties, rendering them persistently active in the absence of endogenous activation. PMID: 23392681
43. metabotropic glutamate receptor 1 is involved in 17beta-estradiol and NMDA-induced neuronal death PMID: 23077075
44. transient receptor potential 3 which is also needed for mGluR1-dependent slow excitatory postsynaptic potentials and motor coordination and associates with protein kinase C gamma PMID: 23115168
45. Data suggest that both T-type and P/Q-type Ca(2+) channels, but not TRPC3 or other Ca(2+) -permeable channels, are involved in mGluR1 and PKC signaling leading to the inhibition of dendritic growth in cerebellar Purkinje cells. PMID: 22188405
46. Group I mGluRs are a potentially important source of neuromodulation within the spinal cord that can modulate the intensity of motoneuron output during motor behavior. PMID: 21346211
47. Disruption of mGluR1 signaling at parallel fiber-Purkinje cell synapses is a major synaptic defect in sg/sg mutant mice, correlating with spinocerebellar ataxia (SCA) type 1 pathology in the extreme mouse model. PMID: 21558162
48. novel insights into the mechanisms of intracellular Ca(2+) mobilization by mGluR5 in the somata of hippocampal neurons PMID: 22028929
49. Low-frequency potentiation of mossy fiber excitatory postsynaptic potentials (EPSP) requires postsynaptic mGlu1 receptors for induction but is expressed presynaptically as an increased release probability. PMID: 22114260
50. Genetic reduction of mGluR1 modified a few select Fmr1 knockout behaviors PMID: 21571007

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KEGG: mmu:14816

STRING: 10090.ENSMUSP00000037255

UniGene: Mm.391904