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  4. Recombinant Mouse Metabotropic glutamate receptor 3 (Grm3), partial

Recombinant Mouse Metabotropic glutamate receptor 3 (Grm3), partial

  • 中文名称：
    小鼠Grm3重组蛋白
  • 货号：
    CSB-YP865599MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Grm3重组蛋白
  • 货号：
    CSB-EP865599MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Grm3重组蛋白
  • 货号：
    CSB-EP865599MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Grm3重组蛋白
  • 货号：
    CSB-BP865599MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Grm3重组蛋白
  • 货号：
    CSB-MP865599MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grm3
  • Uniprot No.：
    Q9QYS2
  • 别名：
    Grm3; Gprc1c; Mglur3; Metabotropic glutamate receptor 3; mGluR3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
  • 基因功能参考文献：
    1. the activation of mGluR3 up-regulates the membrane expression of TWIK-1 that in turn enhances NH4(+) uptake in astrocytes. PMID: 26553349
    2. Activation of Grm3 ameliorates lupus-like disease in mice by reducing B cell numbers. Grm3 expression on B-cells is decreased in lupus-prone mice. PMID: 26071318
    3. The number of mGluR3-immunoractive cells was significantly reduced in the dorsal and intermediate but not ventral parts of the lateral septum in postpartum versus virgin females. PMID: 25739438
    4. GRM3-knockout mice exhibit a biphasic effect in spatial working memory, initially impaired but performing better after training. PMID: 25158312
    5. The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. PMID: 25583490
    6. This study demonistrated that mGluR3 knockout mice show a working memory defect. PMID: 24631392
    7. report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP cleavage in astrocytes, thus enhancing sAPPalpha production PMID: 24291464
    8. study found that astrocytic expression of mGluR5 is developmentally regulated and is undetectable after postnatal week 3; mGluR3, whose activation inhibits adenylate cyclase but not calcium signaling, was expressed in astrocytes at all developmental stages PMID: 23307741
    9. Restraint stress induces a schizophrenia-like phenotype in mice, with epigenetic changes in mGlu2 and mGlu3 receptors that lie at the core of the pathological programming induced by early-life stress. PMID: 22089319
    10. Fractionation of hippocampus-dependent memory depending on the appetitive-aversive context is to our knowledge unique, and suggests a role for group II metabotropic GluRs (mGlu2/3)at the interface of arousal and cognition. PMID: 21832989
    11. This study demonistrated that mGluR3 and not mGluR2 receptors mediate the efficacy of NAAG peptidase inhibitor in validated model of schizophrenia. PMID: 22300789
    12. Following isolation rearing there is an increase in mGluR3 density in prefrontal cortex and hippocampus. PMID: 20970439
    13. These data raise the intriguing possibility that glutamate regulates differentiation of SVZ/NSCs by activating mGlu3 receptors. PMID: 20091783
    14. Group III mGluR may be functionally expressed to suppress self-renewal capacity through a mechanism related to cyclic adenosine monophosphate (cAMP) formation with promotion of subsequent differentiation into astroglial lineage in neural progenitors. PMID: 18266930
    15. In the hippocampus of mGluR3 knockout mice, glutamate transporters EAAT1 and EAAT2 are decreased. PMID: 18720515

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 数据库链接：

    KEGG: mmu:108069

    STRING: 10090.ENSMUSP00000004076

    UniGene: Mm.318966

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