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  4. Recombinant Mouse Mitogen-activated protein kinase kinase kinase 4 (Map3k4), partial

Recombinant Mouse Mitogen-activated protein kinase kinase kinase 4 (Map3k4), partial

  • 中文名称：
    小鼠Map3k4重组蛋白
  • 货号：
    CSB-YP013426MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Map3k4重组蛋白
  • 货号：
    CSB-EP013426MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Map3k4重组蛋白
  • 货号：
    CSB-EP013426MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Map3k4重组蛋白
  • 货号：
    CSB-BP013426MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Map3k4重组蛋白
  • 货号：
    CSB-MP013426MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Map3k4
  • Uniprot No.：
    O08648
  • 别名：
    Map3k4; Mekk4Mitogen-activated protein kinase kinase kinase 4; EC 2.7.11.25; MAPK/ERK kinase kinase 4; MEK kinase 4; MEKK 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
  • 基因功能参考文献：
    1. MAP3K4 activity controls epithelial-to-mesenchymal transition through the ubiquitination and degradation of HDAC6. PMID: 28273454
    2. by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a increases MEKK4 protein kinase activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a-mediated skeletal muscle fiber atrophy. PMID: 27358404
    3. Map3k4 haploinsufficiency is the cause of T-associated sex reversal. PMID: 24452333
    4. regulates epithelial-mesenchymal transition in trophoblast stem cells PMID: 21549327
    5. MTK1 plays an important role in the regulation of cell death and is also involved in the pathogenesis of heart failure. PMID: 19850048
    6. MEKK4 plays a critical role in regulating MKK4 activity and apoptotic cell death during neural tube development. PMID: 15731347
    7. Hindbrains of exencephalic MEKK4(K1361R) embryos show a striking increase in neuroepithelial cell apoptosis and a dramatic loss of phosphorylation of MKK3 and -6, mitogen-activated protein kinase kinases (MKKs) regulated by MEKK4 in the p38 pathway. PMID: 16199873
    8. MEKK4 transcripts was reported in early myocardium, endocardium and in cardiac cushion cells that have executed epithelial to mesenchymal transformation (EMT), suggesting that MEKK4 may function during production of the cushion mesenchyme. PMID: 16894626
    9. our results demonstrate a link between MEKK4 and filamin-a that impacts neuronal migration initiation PMID: 17145501
    10. GSK3beta binding to MEKK4 blocks MEKK4 dimerization that is required for MEKK4 activation, effectively inhibiting MEKK4 stimulation of the JNK and p38 MAPK pathways PMID: 17726008
    11. Results define MEKK4 as a signaling hub for FGF4 activation of JNK that is required for maintenance of trophoblast stem cells in an undifferentiated state. PMID: 19289495
    12. a role for the signalling pathway in mouse sex determination PMID: 19753101
    13. MEKK4 regulates epithelial-to-mesenchymal transition in the endocardial cushions of the developing heart. PMID: 16894626

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  • 亚细胞定位：
    Cytoplasm, perinuclear region. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 组织特异性：
    Widely expressed. High expression was found in skeletal muscle, kidney, testis followed by heart brain and lung. Low expression was found in spleen.
  • 数据库链接：

    KEGG: mmu:26407

    STRING: 10090.ENSMUSP00000086459

    UniGene: Mm.28587

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