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  4. Recombinant Mouse Neurogenic locus notch homolog protein 3 (Notch3), partial

Recombinant Mouse Neurogenic locus notch homolog protein 3 (Notch3), partial

  • 中文名称：
    小鼠Notch3重组蛋白
  • 货号：
    CSB-YP733800MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Notch3重组蛋白
  • 货号：
    CSB-EP733800MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Notch3重组蛋白
  • 货号：
    CSB-EP733800MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Notch3重组蛋白
  • 货号：
    CSB-BP733800MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Notch3重组蛋白
  • 货号：
    CSB-MP733800MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Notch3
  • Uniprot No.：
    Q61982
  • 别名：
    Notch3; Neurogenic locus notch homolog protein 3; Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May play a role during CNS development.
  • 基因功能参考文献：
    1. endothelial expression of Notch3 limits tumour angiogenesis; tumour growth and angiogenesis are increased when Notch3 is silenced in the stroma PMID: 28719575
    2. Double immunostaining with differentiation markers revealed that NOTCH3 was expressed in some undifferentiated and differentiated spermatogonia in mouse testes. PMID: 29161703
    3. We find that across species, the atypical receptor NOTCH3 is differentially overexpressed; it is progressively up-regulated with disease development and promotes tumor cell survival via activation of PI3k-Akt PMID: 27791012
    4. overexpression demonstrates an antiproliferative effect on established metastatic medullary thyroid cancer liver tumors PMID: 29128180
    5. Notch3 mutation impairs recovery of cardiac function post-myocardial ischemia. PMID: 28131704
    6. Notch3 plays an important role in the maintenance of quiescent neural stem cells in the subependymal zone. PMID: 29101245
    7. Knock-in mice with the R169C mutation (Notch3(R170C/R170C)) exhibited similar reductions in arterial lumen, and both TgNotch3(R169C) and Notch3(R170C/R170C) mice showed increased cerebral artery expression of Notch3 target genes. PMID: 27821617
    8. Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions. PMID: 26648042
    9. Mutant Notch3 accumulates in pericytes and causes progressive pericyte loss and BBB leakage in the cerebral cortex in CADASIL mouse model. PMID: 26312599
    10. Relative to air-exposed controls, ozone increased bronchoalveolar lavage fluid protein, a marker of lung permeability, in all genotypes, but significantly greater concentrations were found in Notch4-/- compared with wild-type and Notch3-/- mice. PMID: 25658374
    11. The mechanism of Oncostatin M on cardiac ischemia/reperfusion injury is partly mediated by the Notch3/Akt pathway. PMID: 26093524
    12. miR-7a regulates the differentiation of Muller glia through the suppression of Notch3 expression. PMID: 26122050
    13. Study showed Notch3 expressed in proliferating hippocampal precursor cells and down-regulates their activation and proliferation; adult neurogenesis in CADASIL transgenic mice was altered prior to vascular abnormalities due to deficits in Notch3 signaling PMID: 25555543
    14. NOTCH3, but not NOTCH2 protects vascular smooth muscle cell from apoptosis. PMID: 25957400
    15. Notch3 protein activation in glomeruli promotes the development of progressive renal disease. PMID: 25421557
    16. A viral cyclin-CDK6 complex was found to be a regulator of Notch3 in lymphoma cells. PMID: 25483078
    17. Loss of Notch3 is associated with impaired neuronal maturation. PMID: 25164209
    18. study demonstrates activity-dependent reduction of DLL4 expression and proteolytic cleavage of Notch3 in the hypothalamic-neurohypophysial system. PMID: 24943269
    19. Notch3 is important for survival of vascular smooth muscle cells, and reveal a critical role for Notch3 and VSMC in blood vessel integrity and blood-brain barrier function in the mammalian vasculature. PMID: 25477343
    20. Endogenous activation of Notch3 signaling selectively controls the pool of undifferentiated progenitors of upper airways available for differentiation. PMID: 25564622
    21. Notch3 activation is sufficient but not required for inducing human T-lineage specification. PMID: 25381438
    22. These data indicate that both mTORC1 and Notch3 signaling are involved in HPH and the downstream effects of mTORC1 activation in HPH are partially dependent on the activation of Notch3 signaling. PMID: 24825564
    23. Stroke outcome and memory impairments are worse in notch3 null mice; lack of the notch3 receptor affects white matter stroke susceptibility. PMID: 24723319
    24. cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy can develop without impairment of NOTCH3 signaling PMID: 24425116
    25. High notch3 expression is associated with inflammatory breast cancer that frequently metastasized. PMID: 23928992
    26. Notch3 is expressed in a highly clonogenic and transiently quiescent luminal progenitor population that gives rise to a ductal lineage. PMID: 24100291
    27. Ccr2 deficient mice display increased Notch3 signaling and dysregulated Notch ligand expression. PMID: 23492191
    28. Identify Grip2 and Notch3 target regulating myogenic response of cerebral vessels. PMID: 23117660
    29. Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury. PMID: 22806125
    30. Notch-3 expression is significantly upregulated in renal cells from mice with a targeted disruption of one Y box (YB)-1 allele. PMID: 21372592
    31. Suppression of Notch3 disrupts quiescence and promotes expansion of self-renewing populations. PMID: 21912215
    32. Notch3 is differentially expressed by progenitor thymocytes, peaking at the DN3 progenitor stage. Notch1 & Notch3 carry out nonoverlapping functions during thymocyte differentiation. Notch3 is not essential at later stages. PMID: 21768299
    33. cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy is associated with hypomorphic Notch 3 function in vascular smooth muscle cells. PMID: 21555590
    34. mechanism of Notch activation PMID: 21536678
    35. Data indicate that the cooperation among Notch3, protein kinase C, and p65/NF-kappaB subunit modulates Foxp3 expression. PMID: 21508258
    36. Data show that Notch3 is necessary for the adaptive response of the renal vasculature to vasoactive systems. PMID: 21518968
    37. Dominant mutations in NOTCH3 cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). PMID: 20967782
    38. Data suggest that selective inhibition of Notch signalling mediated by Notch3 or Delta-like1 may offer a new strategy for the treatment of RA. PMID: 21235539
    39. Notch3 pathway might be distinct from Notch1 in muscle regeneration. PMID: 20960513
    40. Notch3 is important for the investment of mural cells and is a critical regulator of developmental and pathological blood vessel formation PMID: 20689064
    41. critical role for lysosomes in the degradation PMID: 19735738
    42. Data show that that the increased Notch3-IC degradation correlates with higher levels of c-Cbl tyrosine phosphorylation in Notch3-IC/pTalpha(-/-) double-mutant thymocytes. PMID: 19966856
    43. component in spermatogenesis and Sertoli cells in neonatal mice PMID: 11700858
    44. expression pattern analyzed in the pre- and postnatal mouse brain; data show expression is conserved between mouse and human and suggest that the mouse is a valid system for analysis of CADASIL PMID: 12126955
    45. Ectopic expression of Notch3 in airway epithelium potentially contributes to the multistep evolution of lung cancer through the inhibition of terminal differentiation. PMID: 12673204
    46. Notch3 is observed in the lower compartment of developing olfactory neuroepithelium until it gradually disappears, which suggests a distinct role for Notch3 in the neurogenesis of the peripheral olfactory system. PMID: 15076712
    47. Heterodimerization of mutant Notch3 with Fringe is associated with pathophysiology of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy PMID: 15857853
    48. results support the idea that other Notch genes functionally compensate for Notch3 during embryonic development PMID: 15882997
    49. activated Notch3 can function as an oncogene in the developing brain, and link the Notch pathway to human choroid plexus tumor pathogenesis PMID: 16186803
    50. Notch3 plays role in the development and transformation of the mammary gland. PMID: 16507912

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Notch 3 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
  • 蛋白家族：
    NOTCH family
  • 组织特异性：
    Proliferating neuroepithelium.
  • 数据库链接：

    KEGG: mmu:18131

    STRING: 10090.ENSMUSP00000085016

    UniGene: Mm.439741

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