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  4. Recombinant Mouse Neurogenic locus notch homolog protein 4 (Notch4), partial

Recombinant Mouse Neurogenic locus notch homolog protein 4 (Notch4), partial

  • 中文名称：
    小鼠Notch4重组蛋白
  • 货号：
    CSB-YP015953MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Notch4重组蛋白
  • 货号：
    CSB-EP015953MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Notch4重组蛋白
  • 货号：
    CSB-EP015953MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Notch4重组蛋白
  • 货号：
    CSB-BP015953MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Notch4重组蛋白
  • 货号：
    CSB-MP015953MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Notch4
  • Uniprot No.：
    P31695
  • 别名：
    Notch4; Int-3; Int3Neurogenic locus notch homolog protein 4; Notch 4) [Cleaved into: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
  • 基因功能参考文献：
    1. Report impaired Notch4 signaling in endothelial progenitor cells isolated from mouse Kawasaki disease model. PMID: 28013300
    2. Notch4-knock-out mice that also lacked Notch1, had defects in all vascular beds. PMID: 27354212
    3. Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. PMID: 25468970
    4. Notch4-deficient mice exhibited slightly delayed vessel growth in the retina, consistent with the novel finding that NOTCH4 protein is expressed in the newly formed vasculature. PMID: 24667410
    5. Notch4 normalization reduces blood vessel size in arteriovenous malformations PMID: 22261032
    6. results demonstrate that whey acidic protein promoter-Int3 has no oncogenic effect upon parity-identified mammary epithelial cells PMID: 21666720
    7. Results indicate the importance of Notch signaling in maintaining the lung vasculature and offer a new, reliable model with which to study the pathobiology of lung arteriovenous shunts and malformations. PMID: 19933399
    8. PBP is essential for the growth of Notch4-immortalized mammary cells by activating SOX10 expression, providing a potential molecular mechanism through which PBP regulates the growth of mammary stem/progenitor cells. PMID: 19852756
    9. Expression of activated Notch1 or Notch4 in endothelial cells causes transdifferentiation to a mesenchymal phenotype. Notch 4 is expressed in the ventricular outflow tract during stages of endocardial cushion formation. PMID: 14988227
    10. Mice carrying a R142C Notch4 knock-in mutation do not develop a CADSIL phenotype. PMID: 15645445
    11. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. PMID: 15994223
    12. Notch4 intracellular domain attenuates TGF-beta signaling in several cell types. PMID: 16007227
    13. DDL4/Notch4 and ephrin B2 pathways downstream of VEGF plays a key role in the abnormal remodeling of tumor vessels PMID: 16951162
    14. establish the molecular basis for a novel activator protein 1/glucocorticoid-Notch4 axis in vascular endothelium PMID: 17220278
    15. Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations. PMID: 18667694
    16. Notch4-induced mammary tumor development is independent of the interaction between its intracellular domain and Rbpj. That interaction is needed for mammary gland development. PMID: 18836481
    17. These findings may suggest the existence of a structural difference(s) between laboratory and wild mice at the Notch-4 locus that regulates the integration of mouse mammary tumor virus proviral DNA. PMID: 19329137

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  • 相关疾病：
    Loss of the extracellular domain causes constitutive activation of the Notch protein, which leads to hyperproliferation of glandular epithelial tissues and development of mammary carcinomas.
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
  • 蛋白家族：
    NOTCH family
  • 组织特异性：
    Highly expressed in lung, moderately in heart kidney, and at lower levels in the ovary and skeletal muscle. A very low expression is seen in the brain, intestine, liver and testis.
  • 数据库链接：

    KEGG: mmu:18132

    STRING: 10090.ENSMUSP00000015612

    UniGene: Mm.173813

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