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  4. Recombinant Mouse Nuclear receptor coactivator 2 (Ncoa2), partial

Recombinant Mouse Nuclear receptor coactivator 2 (Ncoa2), partial

  • 中文名称：
    小鼠Ncoa2重组蛋白
  • 货号：
    CSB-YP015540MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ncoa2重组蛋白
  • 货号：
    CSB-EP015540MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ncoa2重组蛋白
  • 货号：
    CSB-EP015540MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ncoa2重组蛋白
  • 货号：
    CSB-BP015540MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ncoa2重组蛋白
  • 货号：
    CSB-MP015540MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ncoa2
  • Uniprot No.：
    Q61026
  • 别名：
    Ncoa2; Grip1; Src2; Tif2; Nuclear receptor coactivator 2; NCoA-2; Glucocorticoid receptor-interacting protein 1; GRIP-1; Steroid receptor coactivator 2; SRC-2; Transcriptional intermediary factor 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadia...显示更多
  • 基因功能参考文献：
    1. Results suggest that SRC-2 coordinates cardiomyocyte secretion of VEGF downstream of the two major angiogenic stimuli occurring during pressure overload bridging both hypertrophic and hypoxia-stimulated paracrine signaling. PMID: 29127200
    2. studies demonstrate that SRC-2 provides an essential link between the behavioral activities influenced by light cues and the metabolic homeostasis maintained by the liver PMID: 27432117
    3. the expression of MOZ-TIF2 fusion protein represses the transcription of p16INK4a and p19ARF and blocks senescence. PMID: 26854485
    4. findings position SRC-2 as a major regulator of polygenic inputs to metabolic gene regulation and perhaps identify a previously unappreciated model that helps to explain the clinical spectrum of glucose dysregulation PMID: 26487680
    5. In a murine model, overexpression of NCoA2 in the prostate epithelium resulted in neoplasia. PMID: 25295534
    6. the PAX3-NCOA2 fusion gene has a dual role in the tumorigenesis of rhabdomyosarcoma PMID: 24213582
    7. Transcription factor 23 (Tcf23), a basic-helix-loop-helix transcription factor, is a new progesterone-induced target gene that requires SRC-2 for full induction. PMID: 24571987
    8. SRC-2 is a transcriptional coactivator for BMAL1:CLOCK. Ablation of SRC-2 disrupts the central clock. PMID: 24529706
    9. SRC2 regulates anxiety response with SRC2(-/-) females showing decreased anxiety in novel environments. PMID: 23927929
    10. Our results indicate that SRC-2 is involved in maintenance of the steady-state adult heart transcriptional profile, with its ablation inducing transcriptional changes that mimic a stressed heart. PMID: 23300926
    11. Deletion of Ncoa2/Src-2 in mice predisposes to diethylnitrosamine-induced liver tumorigenesis. PMID: 22556267
    12. Pre-treatment with T0901317 before LPS stimulation can suppress the expressions of IRF3 and GRIP1 to inhibit inflammation and Kupffer cell activation. PMID: 19460690
    13. differentially regulates PKA-stimulated transcriptional activity of steroidogenic factor 1 PMID: 11923473
    14. synergistic activation of constitutively active androstane receptor (CAR) by glucocorticoid receptor-interacting protein 1 (GRIP1) results from both nuclear translocation and activation of CAR. PMID: 12000748
    15. cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators, GRIP-1 during skeletal muscle differentiation PMID: 12130539
    16. results indicate a potential role of PIAS3 as transcriptional modulator of TIF2-mediated signalling PMID: 12208521
    17. In white adipose tissue, lack of TIF2 decreases PPARgamma activity and reduces fat accumulation, whereas in brown adipose tissue it facilitates the interaction between SRC-1 and PGC-1alpha, which induces PGC-1alpha's thermogenic activity. PMID: 12507421
    18. TIF2/GRIP1 coactivation of androgen receptor transactivation in recurrent prostate cancer is increased by EGF signaling through MAPK PMID: 14662770
    19. data demonstrate that GRIP1 is ubiquitinated and degraded through activation of the PKA pathway PMID: 15347661
    20. Both SRC1A and p/CIP function as coactivators for MyoD-mediated transcription whereas GRIP1 acts negatively as a (co)repressor. PMID: 15563453
    21. GRIP1 interaction and activation of mCAR in the nucleus result in retention and accumulation of mCAR in the nucleus; model requires that mCAR constantly shuttle between the nucleus and cytoplasm PMID: 15591315
    22. Rb enhances the activity of nuclear receptors through direct interactions with NGFI-B and SRC-2. PMID: 15767262
    23. TIF2 serves as the preferential coactivator for androgen receptor in testis. PMID: 15983373
    24. Competition with glucocorticoid receptor for GRIP1 antagonizes IRF3-mediated transcription. PMID: 16362036
    25. SRC-2 is appropriated by progesterone receptor (PR) in a subset of transcriptional cascades obligate for normal uterine and mammary morphogenesis and function. PMID: 16914740
    26. SRC-2 regulates uterine function by modulating the regulation of developmentally important signaling molecules and the ability of progesterone to repress specific genes. PMID: 17556502
    27. Recent detection of SRC-2 in the human endometrium and breast suggests that this coregulator may represent a new clinical target for the future management of female reproductive health and/or breast cancer. PMID: 18174919
    28. study identified SRC-2 as a regulator of fasting hepatic glucose release, a function that SRC-2 performs by controlling expression of hepatic G6Pase; SRC-2 modulates G6Pase expression by acting as a coactivator with the orphan nuclear receptor RORalpha PMID: 19039140
    29. VDR and coactivators SRC2 and SRC3, which are also involved in other nuclear receptors as well, are critical for epidermis-specific sphingolipid production and barrier formation PMID: 19052561
    30. ER beta, AIB1, and TIF2 appear to be involved in colorectal tumorigenesis and might have prognostic significance. PMID: 19198856
    31. analysis of the skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2 PMID: 19423703
    32. RORa-dependent recruitment to Slc1a6 promoter in cerebellum. PMID: 14687547
    33. supressor of MyoD PMID: 15563453

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SRC/p160 nuclear receptor coactivator family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:17978

    STRING: 10090.ENSMUSP00000006037

    UniGene: Mm.2537

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