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  4. Recombinant Mouse PH and SEC7 domain-containing protein 1 (Psd), partial

Recombinant Mouse PH and SEC7 domain-containing protein 1 (Psd), partial

  • 中文名称：
    小鼠Psd重组蛋白
  • 货号：
    CSB-YP691541MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Psd重组蛋白
  • 货号：
    CSB-EP691541MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Psd重组蛋白
  • 货号：
    CSB-EP691541MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Psd重组蛋白
  • 货号：
    CSB-BP691541MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Psd重组蛋白
  • 货号：
    CSB-MP691541MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Psd
  • Uniprot No.：
    Q5DTT2
  • 别名：
    Psd; Efa6a; Kiaa2011; Psd1; PH and SEC7 domain-containing protein 1; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; Exchange factor for ARF6; Exchange factor for ARF6 A; Pleckstrin homology and SEC7 domain-containing protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor for ARF6. Isoform 2 and isoform 3 induce cytoskeletal remodeling, but lead to distinct morphological changes in HeLa cells: isoform 2 induces cell elongation and formation of actin-rich protrusions, whereas isoform 3 promotes the formation of membrane ruffles and loss of stress fibers.
  • 基因功能参考文献：
    1. Arf6 exchange factor EFA6 and endophilin directly interact at the plasma membrane to control clathrin-mediated endocytosis. PMID: 24979773
    2. EFA6A regulates Arf6-mediated neurite formation through interaction with SNX1. PMID: 24261326
    3. determined the complete primary sequence of mouse EFA6D encoding a protein of 1004 amino acids with a calculated molecular weight of 111,207 Da. PMID: 16707115
    4. EFA6A may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines PMID: 17298598
    5. EFA6A-ARF6 pathway may play a specific role at a subcompartment of perisynaptic photoreceptor processes PMID: 18708035
    6. Results showed that EFA6A was first shown localized intensely in nuclei of spermatocytes of adult testes and suggested a possible involvement of EFA6A-ARF6 signaling in the karyokinesis and cytokinesis. PMID: 19085064

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane. Cell projection, ruffle.; [Isoform 2]: Cell membrane. Cell projection.; [Isoform 3]: Cell membrane. Cell projection, ruffle.; Cell membrane. Cell projection, ruffle membrane. Cleavage furrow.
  • 蛋白家族：
    PSD family
  • 组织特异性：
    Highest expression detected in brain and some expression detected also in uterus, stomach, ovary and intestine, with isoform 2 being expressed at the highest levels. In the brain, isoform 1 is highly expressed in the strata oriens, radiatum, lacunosum-mol
  • 数据库链接：

    KEGG: mmu:73728

    STRING: 10090.ENSMUSP00000039728

    UniGene: Mm.268532

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