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  4. Recombinant Mouse Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partial

Recombinant Mouse Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inpp5d), partial

  • 中文名称：
    小鼠Inpp5d重组蛋白
  • 货号：
    CSB-YP861701MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Inpp5d重组蛋白
  • 货号：
    CSB-EP861701MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Inpp5d重组蛋白
  • 货号：
    CSB-EP861701MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Inpp5d重组蛋白
  • 货号：
    CSB-BP861701MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Inpp5d重组蛋白
  • 货号：
    CSB-MP861701MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Inpp5d
  • Uniprot No.：
    Q9ES52
  • 别名：
    Inpp5d; 7a33; Ship; Ship1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; EC 3.1.3.86; Inositol polyphosphate-5-phosphatase D; EC 3.1.3.56; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; EC 3.1.3.36; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; p150Ship
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Also able to hydrolyze the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminati...显示更多
  • 基因功能参考文献：
    1. We investigated the role of SHIP1 as a tumor suppressor in myeloid leukemia cells in an in vivo xenograft transplantation model. The AML-derived SHIP1Y643H mutant, which has a strongly reduced enzymatic activity showed significant reversion of SHIP1-induced prolongation of the survival time. In addition, analysis of 290 patients revealed a correlation between expression of SHIP1 and overall survival of the AML patients. PMID: 29143813
    2. High SHIP1 expression is associated with lymphoma and colon cancer. PMID: 29018171
    3. These results show that SHIP-1 is required for the maintenance of B10 cells and production of IL-10, and collectively suggests that SHIP-1 could be a new potential therapeutic target for the treatment of autoimmune diseases. PMID: 28972092
    4. Rictor positively regulates B cell receptor signaling via up-regulating Btk and down-regulating SH2-containing inositol phosphatase PMID: 28821013
    5. MiR-155 promotes experimental colitis by repressing SHIP-1 expression. PMID: 28246471
    6. Results are consistent with predicted/observed reduction in the Lyn-SHIP-1-PTEN-SHP-1 axis function in B cells from systemic lupus PMID: 27114609
    7. SHIP has a role in extracellular matrix accumulation via suppressing PI3K/Akt/CTGF signaling in diabetic kidney dise PMID: 27965087
    8. this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a, and accelerates phagosome acidification PMID: 28409542
    9. Our results describe a critical role for SHIP-1 in regulating the ability of dendritic cells to efficiently prime Th2-type responses. PMID: 26518471
    10. Findings indicate a role for inositol-polyphosphate 5-phosphatase SHIP-1 coupling to DC-type lectin receptor ectin-1 hemITAM in the selective control of downstream responses. PMID: 26416276
    11. miR-155 regulates the delicate balance between PAK1-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function. PMID: 26121028
    12. miR-155 regulation of SHIP represents a unique axis that regulates dendritic cells function in vivo. PMID: 26447227
    13. SHIP1 and Csk are part of the PSTPIP2-dependent inhibitory network that prevents the development of autoinflammatory disease. PMID: 26304991
    14. intracellular signaling by SHIP1 in mesenchymal stem cells is critical for hematopoiesis and lineage commitment during aging. PMID: 25525673
    15. Data show that 5'-inositol phosphatase SHIP1 deficiency extrinsically affects invariant NK (iNKT) cell proliferation. PMID: 26232432
    16. Selective deletion of Ship1 in T cells or dendritic cells impairs the formation of an adaptive TH2 response and protects animals from house dust mite-induced allergic airway inflammation. PMID: 25746967
    17. SHIP1 regulates mesenchymal stem cell numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/beta-catenin pathways PMID: 24857423
    18. by promoting survival of protective T cells, thereby preventing an inflammatory myeloid response, SHIP1 maintains an appropriate balance of innate immune function at mucosal surfaces necessary for immune homeostasis. PMID: 24781051
    19. Overexpression of miR-155 in the gouty synovial fluid mononuclear cells leads to suppress SHIP-1 levels and enhance proinflammatory cytokines. PMID: 24708712
    20. Data show that inositol-polyphosphate 5-phosphatase SHIP1 plays a profound NK lineage-intrinsic role in NK cell homeostasis PMID: 25687756
    21. the spontaneous inflammatory disease characteristic of germline SHIP-1 deficiency is not initiated solely by LysM-positive myeloid cells but requires the simultaneous loss of SHIP-1 in other hematolymphoid lineages. PMID: 24598798
    22. miR-155 modulates Reactive oxygen species but not Reactive nitrogen species production by targeting SHIP1, which may provide a better understanding of the host anti-mycobacterial response. PMID: 24937178
    23. A SHIP-deficient bone marrow microenvironment can determine defective hematopoiesis. PMID: 23725762
    24. Results show that SHIP-1 participates in the development, maturation, and effector functions of natural killer (NK) cells. PMID: 23034281
    25. Data indicate that the translation suppression of tumor necrosis factor-alpha (TNFalpha) by interleulin-10 requires the presence of SHIP1 (SH2 domain-containing inositol 5'-phosphatase 1). PMID: 22955274
    26. in normal macrophages, Ship1 is required to limit IL-12production by macrophages and that this in turn is requiredfor the development of a protective T H 2 cell response. PMID: 22535180
    27. Ship1 controls myeloid-derived suppresso cell numbers, in part, by limiting production of the myelopoietic growth factor G-CSF. PMID: 22535653
    28. Wild-type (but not the K370A/K397A substituted) full-length SHIP1 protein, reconstitutes normal inhibition of Fcgamma receptor-mediated phagocytosis when introduced into SHIP1(-/-) murine macrophages, reducing the number of phagocytic events by 2-fold PMID: 22651931
    29. SAP prevents the inhibitory function of SLAM family receptors. This effect is Fyn-independent & correlates with uncoupling of SLAM family receptors from SHIP-1. PMID: 22683124
    30. SHIP1((-)/(-)) neutrophils lose their polarity upon cell adhesion and are extremely adherent, which impairs chemotaxis. PMID: 22323291
    31. Studies using SHIP-1 shRNA, knockout mice and decoy inhibitors further indicate that CD4-mediated inhibition of TCR-mediated T cell activation is SHIP-1 and Dok-1/2 dependent, and involves SHIP-1 hydrolysis of Phosphatidylinositol 3,4,5-trisphosophate PMID: 22370159
    32. SHIP delays the maturation of all three mast cell subsets and, surprisingly, that it is a positive regulator of IgE-induced bone marrow-derived mast cells survival. PMID: 22430739
    33. Data show that the SH2-domain of SHIP1 can bind to the C-terminus of the SHIP1 molecule, most probably by inter- as well as intra-molecular means, and that this interaction regulates the association between different forms of SHIP1 and Ig-alpha. PMID: 22182704
    34. SHIP-1 may regulate immune development that impacts myeloid-derived suppressor cells expansion and function, contributing to pancreatic tumor progression. PMID: 22132131
    35. the interaction between SHIP-1 and CIN85 might synergistically facilitate the down-regulation of phosphatidylinositol-3,4,5-trisphosphate levels. PMID: 21725061
    36. Endotoxin tolerization in vivo blocks TLR4-driven IRAK4 phosphorylation and activation in macrophages, while increasing expression of IRAK-M, SHIP-1, A20 mRNA, and A20 protein. PMID: 21934070
    37. absence of SHIP-1 in B cells led to loss of anergy as indicated by restoration of BCR signaling. PMID: 22078222
    38. SHIP-1 collaborates with sphingomyelin synthase to regulate lymphoma cell death irrespective of the nature of the apoptotic stimulus. PMID: 21793801
    39. Results demonstrate a crucial interplay of Lyn, SHIP, and p85alpha in regulating the normal growth and maturation of bone marrow-derived mast cells, in part by regulating the activation of AKT and the expression of Mitf. PMID: 21791602
    40. SHIP's role in dendritic cell (DC)-induced T cell suppression was examined by co-culturing wild type and SHIP-/- murine DCs. PMID: 21755007
    41. SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis. PMID: 21640975
    42. loss of SHIP-1 alone is not sufficient to cause lung inflammation, with disease only manifest on a permissive genetic background. PMID: 21572033
    43. The data show that reduction of SHIP protein by v-Abl is a critical component in Abelson murine leukemia virus transformation. PMID: 21697469
    44. protein degradation is required for alternative activation of macrophages PMID: 21469115
    45. the el20 mutation reduces expression in SHIP1(el20/el20) macrophages of both SHIP1 and s-SHIP, an isoform of SHIP1 generated by an internal promoter. In contrast, SHIP1(-/-) macrophages express normal levels of s-SHIP. PMID: 21421839
    46. SHIP1 plays an important role downstream of Toll-like receptor 4 signaling in dendritic cells after exposure to proinflammatory diphosphoryl lipid A adjuvant from E. coli or less inflammatory monophosphoryl lipid A. PMID: 21339365
    47. Data show that SHIP-1 acts as a positive regulator in Th2 cells in the adaptive immune response to aeroallergen. PMID: 21151496
    48. SHIP-deficient mice, compared to SHIP-positive mice, are T helper cell type (Th)2 skewed with elevated serum IgE and twice as many splenic CD4-positive Th2 cells that when stimulated produce more IL-4 and less IFN-gamma. PMID: 21131429
    49. activation of SHIP1 by PKA via phosphorylation on Ser(440) is an important regulatory event in hematopoietic cells. PMID: 20810657
    50. SHIP negatively regulates dendritic cell generation and positively regulates Myd88 protein. PMID: 20720161

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane raft. Cytoplasm, cytoskeleton.; [Isoform 5]: Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Inositol 1,4,5-trisphosphate 5-phosphatase family
  • 组织特异性：
    Specifically expressed in immune and hematopoietic cells. Levels vary considerably within this compartment. Lost during erythropoiesis when erythroid cells become Ter119+. Increases substantially with T-cell maturation and when resting B-cells are activat
  • 数据库链接：

    KEGG: mmu:16331

    STRING: 10090.ENSMUSP00000127941

    UniGene: Mm.15105

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