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  4. Recombinant Mouse Potassium channel subfamily U member 1 (Kcnu1), partial

Recombinant Mouse Potassium channel subfamily U member 1 (Kcnu1), partial

  • 中文名称：
    小鼠Kcnu1重组蛋白
  • 货号：
    CSB-YP012100MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Kcnu1重组蛋白
  • 货号：
    CSB-EP012100MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Kcnu1重组蛋白
  • 货号：
    CSB-EP012100MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Kcnu1重组蛋白
  • 货号：
    CSB-BP012100MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Kcnu1重组蛋白
  • 货号：
    CSB-MP012100MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcnu1
  • Uniprot No.：
    O54982
  • 别名：
    Kcnu1; Kcnma3; Ksper; Slo3; Potassium channel subfamily U member 1; Calcium-activated potassium channel subunit alpha-3; Calcium-activated potassium channel; subfamily M subunit alpha-3; Pore-forming subunit of the sperm-specific alkalization activated K(+) current; KSper; Slowpoke homolog 3; mSlo3; pH-sensitive maxi potassium channel
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). Represents the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.
  • 基因功能参考文献：
    1. Considering that capacitation-induced hyperpolarization is mediated by SLO3, we evaluated the action of cSrc inhibitors on the heterologously expressed SLO3 channel. PMID: 26060254
    2. These results establish a critical role of LRRC52 in KSPER channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment. PMID: 25675513
    3. SLO3 K+ channels have a role in controlling calcium entry through CATSPER channels in sperm PMID: 25271166
    4. Using mice lacking both SLO3 and CATSPER1 subunits, the results show conclusively that the voltage-activated outward current present in Slo3 (-/-) sperm is abolished when CATSPER is also deleted. PMID: 23980198
    5. SLO3-dependent hyperpolarization PMID: 23577126
    6. KSper/Slo3 is the primary spermatozoan K(+) channel, and Slo3 is critical for fertility. PMID: 21427226
    7. Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition PMID: 20392696
    8. SLO3 is the principal potassium channel responsible for capacitation-induced hyperpolarization, and membrane hyperpolarization is crucial to the acrosome reaction. PMID: 20138882
    9. voltage and pH regulate a closed-open conformational change in a largely independent fashion PMID: 16940554
    10. increases in pH increase the fraction of more rapidly opening channels. PMID: 16940555
    11. native current observed in sperm is indeed carried by Slo3 channels. PMID: 19338774
    12. results argue that, for native mouse Slo3 channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 alpha subunit PMID: 19578543

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, Calcium-activated (TC 1.A.1.3) subfamily, KCa5.1/KCNU1 sub-subfamily
  • 组织特异性：
    Testis-specific. Mainly expressed in spermatocytes.
  • 数据库链接：

    KEGG: mmu:16532

    STRING: 10090.ENSMUSP00000096457

    UniGene: Mm.289679

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