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  4. Recombinant Mouse Protein Wnt-6 (Wnt6)

Recombinant Mouse Protein Wnt-6 (Wnt6)

In Stock
  • 中文名称：
    小鼠Wnt6重组蛋白
  • 货号：
    CSB-EP026140MO
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Wnt6
  • Uniprot No.：
    P22727
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    50.2 kDa
  • 表达区域：
    24-364aa
  • 氨基酸序列
    LWWAVGSPLVMDPTSICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRVLQQDIRETAFVFAITAAGASHAVTQACSMGELLQCGCQAPRGRAPPRPSGLLGTPGPPGPTGSPDASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRGDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVRKELSLCL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Wnt6 Proteins

靶点详情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
  • 基因功能参考文献：
    1. Wnt6 signals through the canonical pathway in renal epithelial cells as evidenced by increased phosphorylation of GSK3beta ), nuclear accumulation of beta-catenin and increased TCF/Lef transcriptional activity PMID: 27122540
    2. A negative feedback loop involving WNT6 and DKK1 attenuates canonical WNT6-beta-catenin signaling, thereby allowing teratocarcinoma cells to differentiate. PMID: 28177772
    3. Sertoli cells secrete Wnt6 as a paracrine signal for undifferentiated spermatogonia. PMID: 26929341
    4. Wnt6 is a novel factor driving macrophage polarization toward an M2-like phenotype. These findings point to an unexpected role for Wnt6 in macrophage differentiation in the M. tuberculosis-infected lung. PMID: 24123681
    5. GATA6 and FOXA2 bind the Wnt6 promoter and regulate its activity, leading to primitive endoderm formation. PMID: 22607194
    6. WNT6 and Cav1 are upregulated by chemotherapeutics and enhance the resistance of GC cells to anthracycline drugs PMID: 22370641
    7. expressed in the ureter bud and induces kidney tubule development in vitro PMID: 11948913
    8. Wnt6 is able to regulate the development of epithelial somites PMID: 15196961
    9. Identify Wnt6-beta-catenin-Snail signalling cascade involved in epithelial-to-mesenchymal transitions in embryogenesis and metastasis. PMID: 18160257

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Wnt family
  • 组织特异性：
    Detected in ileum, colon and stomach (at protein level).
  • 数据库链接：

    KEGG: mmu:22420

    STRING: 10090.ENSMUSP00000006716

    UniGene: Mm.268282

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