Recombinant Mouse Protein-tyrosine kinase 2-beta (Ptk2b), partial

1. Pyk2 has a role in spine structure and synaptic function; its deficit contributes to Huntington's disease cognitive impairments PMID: 28555636
2. the non-receptor protein tyrosine kinase 2 beta (PTK2B) plays a critical role in murine beige adipocyte differentiation. PMID: 29750960
3. Data provide evidence that activated PYK2 may function as a component of the microtubule organizing center to regulate spindle assembly during the meiotic process of mouse oocytes. PMID: 28643946
4. results suggest that although Pyk2 and FAK are involved in inflammasome activation, only Pyk2 directly phosphorylates ASC and brings ASC into an oligomerization-competent state by allowing Tyr146 phosphorylation to participate ASC speck formation and subsequent NLRP3 inflammation. PMID: 27796369
5. Osteoprotegerin may induce podosome reassembly and peripheral adhesive structure detachment by modulating phosphorylation of Pyk2 and Src and their intracellular distribution in osteoclasts. PMID: 26743491
6. These results suggest that mechanical stimuli activate P2X7 might induce ECMPs expression through PYK2 except in the case of OPN expression. Altogether, mechanical stimuli-induced ECMPs production might be implicated by extracellular ATP secretion or integrin via PYK2 activation. PMID: 29061307
7. Lineage-tracing of monocyte populations suggests that Pyk2 promotes apoptosis in BM monocytes, thereby acting as an important homeostatic regulator of turnover in these short-lived, innate immune cells. PMID: 28754799
8. Pyk2 selectively contributes to the coordination of phagocytosis-promoting signals downstream of CR3, but is dispensable for FcgammaR-mediated phagocytosis PMID: 26848986
9. the findings suggest a model in which the oocyte is not a passive participant in fertilization, but instead responds to sperm contact by localized PYK2 signaling that promotes actin remodeling events required to physically incorporate the sperm head into the ooplasm. PMID: 28527703
10. results show that Pyk2 contributes to cytotoxic T lymphocyte(CTL) migration by regulating detachment of CTL at the trailing edge, which could explain why Pyk2 is important for chemotactic and migratory responses. PMID: 27456486
11. Defects in Pyk2 suppress Kawasaki Disease-like experimental vasculitis, presumably through CXCL9- and CXCL10-dependent interference with neo-angiogenesis. Since Pyk2-KO mice show no life-threatening phenotype, Pyk2 may be a promising therapeutic molecular target for KD. PMID: 28167306
12. STIM1-induced Ca(2+) signaling activates Pyk2 to inhibit the interaction of VE-PTP and VE-cadherin and hence increase endothelial permeability. PMID: 28385807
13. At fertilization, Pyk2 and p-Pyk2 were detected predominantly in sperm heads and the oocyte cytoplasm. Upon formation of male and female pronuclei, Pyk2 and its activated form accumulate in the two pronuclei. Pyk2 was in blastomere nuclei and the pre-blastula cytoplasm. Pyk2 and its activated form then localized to the perinuclear regions, where blastula cells come into contact with each other. PMID: 27086609
14. Findings indicate the presence of unique and overlapping Pyk2 signaling pathways in osteoblasts, which may be controlled by regulating the phosphorylation, kinase activity, and scaffolding functions of Pyk2. PMID: 26552846
15. Astrocytes from Pyk2-/- mice displayed a slower wound covering as compared with wild-type littermate mice after a mechanical stab lesion, data confirmed in purified astrocytes in vitro; actin polymerization dynamics was altered in Pyk2-/- astrocytes; gelsolin, an actin-capping protein able to interact with Pyk2, was mislocalized in Pyk2-/- migrating astrocytes compared with Pyk2+/+ astrocytes PMID: 26663135
16. Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer. PMID: 26330541
17. Src has a role in priming Pyk2 (but not FAK) phosphorylation and subsequent activation downstream of integrins PMID: 26866924
18. Resistance to hypoxia-induced PH was markedly higher in Pyk2-deficient mice than in wild-type mice. Pyk2-dependent generation of ROS is necessary for the activation of HIF-1alpha. PMID: 25659487
19. data suggest a novel role for FAK in GPVI-dependent ROS formation and platelet activation and elucidate a proximal signaling role for FAK within the GPVI pathway. PMID: 25415317
20. Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy. PMID: 24713463
21. PTK2b was activated during the first few hours after fertilization of the oocyte during the period when anaphase resumption was underway and prior to the pronuclear stage. PMID: 24667605
22. Pyk2 is essential for skin wound reepithelialization in vivo and in vitro and that it regulates epidermal keratinocyte migration via a pathway that requires PKCdelta and MMP functions. PMID: 24598361
23. Data indicate that CD45 functions to regulate Pyk2/FAK activity, likely through the activity of Src family kinases, which in turn regulates the levels of paxillin to modulate macrophage adhesion and migration. PMID: 23936270
24. the important role of Pyk2 in the MK-induced increase in bone volume PMID: 23362087
25. The PYK2 kinase was found to be concentrated and activated at the site of sperm-oocyte interaction, and likely participates in this response. PMID: 23401167
26. PTP-PEST controls actin rearrangement, chemokine-triggered migration, and integrin-induced adhesion, seemingly through Pyk2 PMID: 23589331
27. The expression of Pyk2 is correlated with oxygen-induced retinal neovascularization. PMID: 22800456
28. The results of the present study show the importance of the focal adhesion kinase Pyk2 downstream of G-protein-coupled receptors in supporting platelet aggregation and thrombus formation. PMID: 23175689
29. Pyk2 regulates H+-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1/2 signaling pathway. PMID: 22811489
30. We conclude that FAK contributes to cytokine signaling and bone resorption in osteoclasts and partially compensates for the absence of Pyk2 to maintain proper adhesion structures in these cells PMID: 22941736
31. the first study to identify Pyk2 as a substrate for STEP. PMID: 22544749
32. MKs regulate the expression of two alternatively spliced isoforms of Pyk2 in OBs, which may regulate OB differentiation and proliferation. PMID: 22447931
33. the dephosphorylation of Pyk2 requires dynamin's GTPase activity and is mediated by the tyrosine phosphatase PTP-PEST. PMID: 22342188
34. Activation of Pyk2 in the heart during heart failure may contribute to protection against arrhythmia. PMID: 21666110
35. FAK is expressed only in PMA-resistant (or intermediate phenotype) EL4 cells, correlating with enhanced cell-substrate adherence, while Pyk2 is more highly expressed in non-adherent PMA-sensitive cells. PMID: 21533871
36. FAK and Pyk2 have distinct, non-redundant functions in launching mechanical signals during osteoblast mechanotransduction PMID: 21283581
37. Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. PMID: 21471206
38. Hypophosphorylated and inactive Pyk2 associates with paxillin at the microtubule organizing center PMID: 21195757
39. Data suggest cell type- and stage-specific roles for PTK2B during early testis development. PMID: 20737507
40. Nonreceptor tyrosine kinase Pyk2 has an important role in the integrin-mediated activation of neutrophils that contributes to normal degranulation responses required for efficient host defense to Staphylococcus aureus infection. PMID: 21187437
41. Pyk2 acts as an early sensor of numerous extracellular signals that trigger a Ca(2+) flux and/or reactive oxygen species to amplify tyrosine phosphorylation signaling events. PMID: 20688918
42. PTP-PEST controls Pyk2 activity and is a positive regulator of secondary T cell activation. PMID: 20727793
43. Studies indicated that the roles of FAK in tumorigenesis are different among the tumor species. PMID: 19458494
44. Elucidating the detailed mechanism by which forces are generated and transmitted in relation to Pyk2 expression and cytoskeletal organization is the basis of this investigation. PMID: 20170630
45. Pyk2, which is essential for inflammatory cell migration in vitro, regulates airway inflammation, Th2 cytokine secretion, and airway hyperresponsiveness in the ovalbumin-sensitized mice during antigen challenge in vivo. PMID: 19520918
46. Pyk2 functions to limit p53 levels, thus facilitating cell growth and survival in a kinase-independent manner. PMID: 19880522
47. regulation of tyrosine phosphorylation by focal adhesion kinase PMID: 11787067
48. Results delineate a cardiomyocyte signaling pathway involving pyk2/related focal adhesion tyrosine kinase (RAFTK) that has potential relevance for cardiac remodeling, focal adhesion reorganization, and loss of contractility. PMID: 12228222
49. role in adhesion-induced association with c-Src, osteoclast spreading, and bone resorption PMID: 12514172
50. Results suggest that proline-rich tyrosine kinase 2 (PYK2) is a regulator of gelsolin, revealing a novel PYK2-gelsolin pathway in regulating actin cytoskeletal organization in multiple cells, including osteoclasts. PMID: 12578912

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KEGG: mmu:19229

STRING: 10090.ENSMUSP00000022622

UniGene: Mm.21613