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  4. Recombinant Mouse Proto-oncogene vav (Vav1), partial

Recombinant Mouse Proto-oncogene vav (Vav1), partial

  • 中文名称：
    小鼠Vav1重组蛋白
  • 货号：
    CSB-YP025803MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Vav1重组蛋白
  • 货号：
    CSB-EP025803MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Vav1重组蛋白
  • 货号：
    CSB-EP025803MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Vav1重组蛋白
  • 货号：
    CSB-BP025803MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Vav1重组蛋白
  • 货号：
    CSB-MP025803MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Vav1
  • Uniprot No.：
    P27870
  • 别名：
    Vav1; Vav; Proto-oncogene vav; p95vav
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
  • 基因功能参考文献：
    1. the depletion of the micro RNA processing enzyme dicer in Vav1-positive cells allows interfering with post-yolk sac microglia recruitment PMID: 29704636
    2. this study reveals a novel function of Vav1 in regulating mesenchymal stem cell fate decisions for differentiation through Sirt1. PMID: 26990002
    3. Data show that GEF Vav1 possesses tumor-suppressor functions in immature T cells. PMID: 29136506
    4. Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 activity and Grb2 stability PMID: 27188442
    5. Vav1 adaptor has a role in the production of inflammatory cytokines by effector T cells and in the susceptibility to neuroinflammation PMID: 27438086
    6. provide evidence that CD28 and the TCR complex regulate NF-kappaB via different signaling modules of GRB-2/VAV1 and LAT/ADAP pathways respectively. PMID: 25455592
    7. Platelet P-Rex and Vav family Rac-GEFs play important proinflammatory roles in leukocyte recruitment. PMID: 25538043
    8. The data show that vav1 not only affects transcription of the MHCII locus but also is an important regulator of MHCII protein transport to the cell surface. PMID: 23391492
    9. analyses revealed a SHP2- and Lyn-dependent pathway leading to phosphorylation of Vav1, Rac activation, and F-actin polymerization in SCF-treated BMMCs PMID: 24733849
    10. Data indicate that Vav1 was a key negative regulator of macrophage-derived IL-6 production. PMID: 24532586
    11. Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages. PMID: 23825946
    12. Suggest that Vav1 act as critical molecular link coupling hyperlipidemia with proatherogenic monocyte/macrophage responses. PMID: 23825362
    13. Loss of Vav1 activity does not favour development of colitis-associated colon cancer. PMID: 23435399
    14. SAP couples SLAM family receptors to the kinase Fyn, which triggered the exchange factor Vav-1 and augmented NK cell activation. PMID: 22683124
    15. the GDP exchange factor activity is required for T cell mediated allograft rejection PMID: 22456277
    16. The oncogenic truncation of this region elicits conformational changes that interfere with the Vav1-mediated activation of PLCgamma1 and that inhibit calcium mobilization. PMID: 22474331
    17. Dectin-1 activates the integrin Mac-1 in neutrophils via Vav1 and Vav3 signaling to promote Candida albicans clearance. PMID: 22177564
    18. identified previously unknown components of the CD36 signaling pathway, demonstrating that Vav proteins regulate oxLDL uptake and foam cell formation via calcium- and dynamin 2-dependent processes PMID: 21865158
    19. Data show that abnormal perivascular localization correlated with decreased retention of Vav1(-/-) HSPC in the bone marrow (44-60% reduction at 48 h posttransplant. PMID: 21606370
    20. Cbl inactivation reverses the deficiency of T cell development in Vav1 knockout mice PMID: 21490975
    21. LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade PMID: 21206905
    22. CD36 contributes to activation of Vav-1, -2, and -3 in aortae from hyperlipidemic mice PMID: 21209086
    23. Either Vav1 or P-Rex1 alone can produce sufficient active Rac for G protein-coupled receptor (GPCR)-dependent cell responses but under normal circumstances both contribute, presumably to ensure robust cell responses of primary neutrophils. PMID: 21178006
    24. Themis2 was inducibly tyrosine phosphorylated upon LPS challenge and interacted with Vav (P27870). PMID: 20644716
    25. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    26. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    27. These data reveal unexpected negative roles for Vav1 and RasGRF2 in different stages of T-cell lymphoma progression. PMID: 20011522
    28. GEF activity of Vav1 was not required for TCR-induced calcium flux, activation of extracellular signal-regulated kinase and protein kinase D1, and cell polarization PMID: 20009105
    29. Study reports the structure and biophysical and cellular analyses of the five-domain autoinhibitory element of Vav1; the catalytic Dbl homology (DH) domain of Vav1 is controlled by two energetically coupled processes. PMID: 20141838
    30. propose here a model in which Vav functions primarily as a tyrosine phosphorylated linker-protein for TCR activation of T cells PMID: 19672294
    31. Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway PMID: 11790798
    32. Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain. PMID: 11885979
    33. novel role for Vav1 in the regulation of TCR-induced integrin clustering and cell adhesion PMID: 11911819
    34. Vav regulates phagocytosis through subsequent catalysis of GDP/GTP exchange on Rac PMID: 11950933
    35. Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. PMID: 11956228
    36. transduces T cell receptor signals to the activation of phospholipase C-gamma1 via pi 3-kinase dependent and indepent pathyways PMID: 11994416
    37. A component of transcriptionally active complexes PMID: 11994417
    38. Vav contains pleckstrin homology and cysteine-rich domains critical for signaling PMID: 12177050
    39. Results indicate that several Vav domains (Dbl homology, pleckstrin homology, and zinc finger) are essential for all the biological activities tested, whereas others are required for discrete, cell type-specific biological effects. PMID: 12228230
    40. Vav1 contributes to platelet aggregation by CRP and thrombin, but is not required for regulation of phospholipase C. PMID: 12411320
    41. Vav1(-/-) animals were resistant to MOG(35-55)-EAE since the priming and in vivo expansion of MOG-specific T cells was inefficient despite fully functional antigen presentation. PMID: 12799016
    42. Vav is regulated by Cbl in human and mouse cells PMID: 12881521
    43. Vav1 synergizes with or amplifies pathways acting through Rho/Rac GTPases and is essential for fully intact coupling of N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced signaling to downstream neutrophil functions. PMID: 14530369
    44. Vav1 plays a role in LPS-mediated macrophage activation and iNOS production, and vav1 functions in part via activation of NF-IL-6. PMID: 15138177
    45. Vav1 and Vav3 proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis. PMID: 15249579
    46. Three Vav proteins (vav1,vav2 and vav3) function specifically in distinct pathways that trigger NK cell cytotoxicity. PMID: 15365099
    47. results demonstrate that Vav3 and Vav1 play crucial but redundant roles in the activation of phospholipase C gamma 2 by glycoprotein GPVI PMID: 15456756
    48. PI3K activation is Vav-independent in response to strong signals delivered by multivalent cross-linking PMID: 15494014
    49. full Vav transforming activation is mediated by the activation of multiple small GTPases and their subsequent activation of signaling pathways that regulate changes in gene expression PMID: 15634759
    50. Vav1 is selectively required for IL-4 and c-Maf expression, a requirement reflecting, at least in part, the dependence of c-Maf expression on Ca2+/NFAT signaling PMID: 15845902

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  • 组织特异性：
    Widely expressed in hematopoietic cells but not in other cell types. Found in the spleen and lung.
  • 数据库链接：

    KEGG: mmu:22324

    STRING: 10090.ENSMUSP00000005889

    UniGene: Mm.248172

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