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  4. Recombinant Mouse SH3 and multiple ankyrin repeat domains protein 1 (Shank1), partial

Recombinant Mouse SH3 and multiple ankyrin repeat domains protein 1 (Shank1), partial

  • 中文名称：
    小鼠Shank1重组蛋白
  • 货号：
    CSB-YP021247MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Shank1重组蛋白
  • 货号：
    CSB-EP021247MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Shank1重组蛋白
  • 货号：
    CSB-EP021247MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Shank1重组蛋白
  • 货号：
    CSB-BP021247MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Shank1重组蛋白
  • 货号：
    CSB-MP021247MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Shank1
  • Uniprot No.：
    D3YZU1
  • 别名：
    Shank1; SH3 and multiple ankyrin repeat domains protein 1; Shank1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function. ...显示更多
  • 基因功能参考文献：
    1. A review: Shank1 knockout mouse model for autism spectrum disorder (ASD) displays moderate impairments in (I) social behavior, (II) communication, and (III) repetitive and stereotyped patterns of behavior, together with (IV) aberrant cognitive phenotypes, consistent with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions. PMID: 28963042
    2. Study demonstrates that SHANK1 is developmentally expressed in hippocampal neurons and glial cells. Although the specific role for this developmental expression pattern in these different cell types is not fully understood, the current study provides the first developmental cell-type-specific expression profile. PMID: 29218848
    3. Expression of SHANK genes is a key component of autism spectrum disorder-associated pathways as the protein products are enriched in the postsynaptic density (PSD) of glutamatergic neurons. PMID: 26419918
    4. The findings of this study indicated that Shank1 deletions lead to an aberrant cognitive phenotype characterized by severe impairments in object recognition memory and increased hippocampal BDNF levels, possibly due to epigenetic modifications. PMID: 28500650
    5. reduction of PV(+) neurons was in all cases, i.e., in PV+/-, Shank1-/- and Shank3B-/- mice, was due to a reduction in Pvalb mRNA and PV protein PMID: 26819149
    6. Results suggest that Shank1 scaffold in PV+ interneurons regulates excitatory synaptic strength and participates in the maintenance of excitatory and inhibitory balance in excitatory neurons. PMID: 25816842
    7. Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear. PMID: 25637745
    8. This study demonistrated that Shank1+/- heterozygous and to a lesser extent Shank1-/- null mutant mice displayed slightly elevated levels of self-grooming behavior as adults, but not as juveniles. PMID: 24820912
    9. These findings provide convincing evidence for Shank 1A expression in both the inner and outer plexiform layers, and indicate a potential role for PSD-95/Shank 1 complexes at cone synapses in the outer retina. PMID: 22984429
    10. Shank1 null mice do not demonstrate autism-relevant social interaction deficits, but confirm and extend a role for Shank1 in motor functions. PMID: 20868654
    11. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism. PMID: 21695253
    12. These results affirm the importance of Shank1 for synapse structure and function in vivo, and they highlight a differential role for Shank1 in specific cognitive processes. PMID: 18272690

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  • 亚细胞定位：
    Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    SHANK family
  • 组织特异性：
    In brain, highly expressed in cortex, hyppocampus and cerebellum.
  • 数据库链接：

    KEGG: mmu:243961

    STRING: 10090.ENSMUSP00000103571

    UniGene: Mm.360368

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